Results 81 to 90 of about 850,081 (293)
Radical History ReviewHarm reduction and risk reduction: practices at the intersection of queer, addiction and antiracist activism, which refuses to ask the question of use and dependence from the point of view of eradication, and instead embarks on the definitively impure paths of mutual aid. A pleasure activism and everyday life willfulness, a poem for survival.
Bigé, Emma, Dormeau, Léna
+5 more sources
Britain's alcohol problem and what the UK government is (and is not) doing about it [PDF]
, 2006 Britain is currently experiencing a serious alcohol problem, as shown particularly by a steep increase in rates of liver cirrhosis mortality and by widespread alcohol-related disorder and harm among young people.
Heather, Nick
core
Survey of abuses against injecting drug users in Indonesia [PDF]
, 2009 In Indonesia, an ongoing government "war on drugs" has resulted in numerous arrests and anecdotal reports of abuse in detention, but to date there has been little documentation or analysis of this issue.
Sara LM Davis +2 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Defending a Rule of Institutional Autonomy on No-Harm Grounds [PDF]
, 2004 The argument I sketch here for institutional autonomy is basically empirical and agrees with Professor Hamilton in making harm-reduction the overriding social goal. The argument proceeds in two steps.
Tushnet, Mark V.
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2014 Harm reduction is an evolving prevention and practice model for helping professionals that views any positive change in undesired, problematic, or risky target behaviors as a successful outcome. Harm reduction represents a significant shift away from the absolute, all-or-nothing expectations of traditional, medical-model-based approaches commonly ...
+4 more sources
Harm Reduction Journal, 2020 Background This study examines the use of new psychoactive substances (NPS) and the harm reduction response in six Eurasian countries: Belarus, Moldova, Serbia, Kazakhstan, Kyrgyzstan, and Georgia.
Eliza Kurcevič, Rick Lines
doaj +1 more source
Intention to Switch to Smokeless Tobacco Use among South African Smokers: Results from the 2007 South African Social Attitudes Survey [PDF]
, 2014 Background: Some smokeless tobacco products (SLT) have been shown to be associated with only a fraction of the risks of cigarettes. This study assessed South African smokers’ interest in switching to a hypothetical reduced harm SLT product.
Agaku, Israel T., Ayo-Yusuf, Olalekan A.
core +4 more sources