Results 81 to 90 of about 824,404 (357)

Identifying spin bias of nonsignificant findings in biomedical studies

BMC Research Notes, 2023
Objective The purpose of this research note is to share a technique for the identification of spin bias that we developed as part of a living systematic review on the cardiovascular testing of e-cigarette substitution for cigarette smoking.
Renée O’Leary, Giusy Rita Maria La Rosa, Robin Vernooij, Riccardo Polosa   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Smoking Harm Reduction

American Journal of Public Health, 2016
A letter to the editor is presented in response to the article "New product marketing blurs the line between nicotine replacement therapy and smokeless tobacco products," by Ganna Kostygina, Lucinda England and Pamela M. Ling along with a response from the authors.
openaire   +3 more sources

Harm reduction in tobacco control [PDF]

Journal of Public Health, 2008
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Hedley, AJ, McGhee, SM
openaire   +5 more sources

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Measuring sustainability of opioid agonist therapy programs in the context of transition from Global Fund support

Harm Reduction Journal
Background Programmatic and financial sustainability of health responses dependent on donor funding has risen as a major concern. In the HIV field in particular, it generated a number of instruments and assessments on sustainability and processes related
Raminta Stuikyte, Ivan Varentsov, Catherine Cook, Sergii Dvoriak   +3 more
doaj   +1 more source

Insufficient access to harm reduction measures in prisons in 5 countries (PRIDE Europe): a shared European public health concern [PDF]

, 2015
Background: Prisoners constitute a high-risk population, particularly for infectious diseases. The aim of this study was to estimate the level of infectious risk in the prisons of five different European countries by measuring to what extent the prison ...
Brentari, Cinzia, Holm, Karina, Jauffret-Roustide, Marie, Kolind, Torsten, Lion, Caroline, M Carrieri, Patrizia, Maguet, Olivier, Michel, Laurent, Moser, Andrea, Nava, Felice, Schiltz, Julie, Stöver, Heino, Van Malderen, Sara, Vanderplasschen, Wouter, Weltzien, Nadja   +14 more
core   +5 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Britain's alcohol problem and what the UK government is (and is not) doing about it [PDF]

, 2006
Britain is currently experiencing a serious alcohol problem, as shown particularly by a steep increase in rates of liver cirrhosis mortality and by widespread alcohol-related disorder and harm among young people.
Heather, Nick
core  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source