Results 31 to 40 of about 3,677 (212)

Harmful by Design—a Qualitative Study of the Health Impacts of Immigration Detention

Journal of General Internal Medicine, 2022
The USA has the largest immigration detention system in the world with over 20,000 individuals imprisoned by Immigration and Customs Enforcement (ICE) daily. Numerous reports have documented human rights abuses in immigration detention, yet little is known about its health impacts.To characterize how the US immigration detention system impacts health ...
Chanelle Diaz, Veronica Ortiz, Lesly Sanchez, Jose Fernandez, Elí A. Andrade, Matthew J. Akiyama, Jonathan Ross   +6 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Local knowledge and derived practices of safety during pregnancy, childbirth and postpartum: a qualitative study among nurse-midwives in urban eastern Tanzania

BMJ Open, 2022
Background Maternal and newborn mortality are still high in low-income and middle-income countries despite global efforts to improve the quality of care by prioritising evidence-based practices and increasing the number of births attended by skilled ...
Beatrice Mwilike, Yoko Shimpuku, Dorkasi L Mwakawanga, Morie Kaneko   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Harmful incidents following gynaecological ambulatory surgery: A scoping review

International Journal of Nursing Studies Advances
Aim: To map the types and frequencies of harmful incidents identified in research to occur following gynaecological ambulatory surgery. Design and methods: A scoping review was conducted using the JBI Manual for Evidence Synthesis. Data Sources: MEDLINE,
Cathrine Ween Thoen, Malin Knutsen Glette, Siri Wiig, Kim Christian Danielsson, Signe Berit Bentsen   +4 more
doaj   +1 more source

Transforming carbon dioxide into jet fuel using an organic combustion-synthesized Fe-Mn-K catalyst

Nature Communications, 2020
Design and discovery of catalysts to make clean energy and mitigate the harmful effect of greenhouse gases remains a massive challenge. Here the authors report a combustion-synthesised iron-based catalyst of high activity and selectivity for directly ...
Benzhen Yao, Tiancun Xiao, Ofentse A. Makgae, Xiangyu Jie, Sergio Gonzalez-Cortes, Shaoliang Guan, Angus I. Kirkland, Jonathan R. Dilworth, Hamid A. Al-Megren, Saeed M. Alshihri, Peter J. Dobson, Gari P. Owen, John M. Thomas, Peter P. Edwards   +13 more
doaj   +1 more source

Advanced Materials Design for Adsorption of Toxic Substances in Cigarette Smoke

Advanced Science, 2023
Cigarettes, despite being economically important legal consumer products, are highly addictive and harmful, particularly to the respiratory system. Tobacco smoke is a complex mixture containing over 7000 chemical compounds, 86 of which are identified to ...
Ting Zeng, Yanxia Liu, Yingfang Jiang, Lan Zhang, Yagang Zhang, Lin Zhao, Xiaoli Jiang, Qiang Zhang   +7 more
doaj   +1 more source

Designing Remedies to Compensate Plaintiffs for Unobservable Harms [PDF]

American Law and Economics Review, 2017
Despite the vast sums transferred through the legal system, the foundations of the procedures used to compensate plaintiffs for unobservable losses remain unclear. Standard remedies can compensate plaintiffs for unknown harms, but it is expensive to do so.
openaire   +1 more source