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Rainwater harvesting is a common practice in several parts of the world. It can be used for very diverse purposes, such as human consumption, livestock and agricultural production, and flood control. A rainwater harvesting system is conceived when a catchment surface is connected to a storage reservoir.
Galvão, Carlos de Oliveira +2 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Navigating the Fault Lines in Civic Food Networks
Journal of Agriculture, Food Systems, and Community Development, 2016 Civic food networks have emerged as a civil society–driven response to the social, economic, and environmental shortcomings of the industrial food system.
Colin Ray Anderson +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Julius-Kühn-Archiv, 2018 ECO₂FUME® fumigation of maize bag stacks under gas proof sheets was conducted to establish the optimal dosages (application rate) and exposure times (fumigation period) against mixed-age cultures of Sitophilus zeamais and Tribolium castaneum.
Kengkanpanich, Rungsima +3 more
doaj +1 more source
Obstruction of Water Uptake in cut Chrysanthemum Stems after Dry Storage: Role of Wound-induced Increase in Enzyme Activities and Air Emboli [PDF]
, 2009 Hydraulic conductance of cut chrysanthemum stems was lowered by the aspiration of air as well as by a wound-induced plant response. By measuring the hydraulic conductance of stem segments in which air could be introduced into and/or removed from the ...
Arevalo-Galarza, L., Meeteren, U., van
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FoodsMango seed kernels, an underutilized by-product of the mango pulping industries, are a rich supplier of metabolites, specifically phenolic and flavonoid compounds. These compounds have potential health benefits.
Poonam Choudhary +5 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source