Results 81 to 90 of about 1,861,840 (333)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Investigating the Antioxidant Potential of Mango Seed Kernel Polyphenols: Extraction and Optimization Strategies

Foods
Mango seed kernels, an underutilized by-product of the mango pulping industries, are a rich supplier of metabolites, specifically phenolic and flavonoid compounds. These compounds have potential health benefits.
Poonam Choudhary, Sandeep P. Dawange, Thingujam Bidyalakshmi, Ramesh Chand Kasana, Kairam Narsaiah, Bhupendra M. Ghodki   +5 more
doaj   +1 more source

Efficacy studies on ECO₂FUME® phosphine fumigant for complete control of Sitophilus zeamais and Tribolium castaneum in stored maize in Thailand

Julius-Kühn-Archiv, 2018
ECO₂FUME® fumigation of maize bag stacks under gas proof sheets was conducted to establish the optimal dosages (application rate) and exposure times (fumigation period) against mixed-age cultures of Sitophilus zeamais and Tribolium castaneum.
Kengkanpanich, Rungsima, Suthisut, Duangsamorn, Noochanapal, Pavinee, Pobsok, Panania   +3 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Physicochemical Properties and Storage Stability of Restructured Products Prepared from Mantis Shrimp at Refrigerated Temperature (4±1°C)

International Journal of Bio-Resource and Stress Management
The experiment was conducted from January to August, 2023 at Central Institute of Fisheries Education, Mumbai, Maharashtra, India, to evaluate nutritionally rich restructured fish products, such as sausages, using mantis shrimp (Miyakella nepa).
D. Varsha, A. K. Balange, P. Layana, R. P. Deepitha, D. Abuthagir Iburahim, S. A. Joshi, S. B. Gore   +6 more
doaj   +1 more source

HARVEST, a longitudinal patient record summarizer

J. Am. Medical Informatics Assoc., 2014
Objective To describe HARVEST, a novel point-of-care patient summarization and visualization tool, and to conduct a formative evaluation study to assess its effectiveness and gather feedback for iterative improvements.
J. Hirsch, Jessica S. Tanenbaum, S. Gorman, Connie Liu, E. Schmitz, Dritan Hashorva, Artem Ervits, D. Vawdrey, M. Sturm, Noémie Elhadad   +9 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

High value fermented nutraceutical product from pomegranate aril and rind blends

Environment Conservation Journal, 2019
Nutraceutical enriched blended beverages were prepared by using different fruit combination of pomegranate, jamun, kokum and pomegranate rind powder, where the TSS (14 °B) was maintained by using raisin syrup.
M Karan,, K.N. Sreenivas, G.S. Manjula, R.M. Chirag, Mohamad Tayeeb Ulla, H.   +4 more
doaj   +1 more source

Gravel galore: Impacts of clear-cut logging on salmon and their habitats [PDF]

, 2002
Timber harvest may have both direct and indirect effects on salmon, and with a few exceptions those effects result in lowered survival of salmon in their stream habitats compared with unlogged forest (Hicks et al. 1991b).
Hicks, Brendan J.
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source