Results 71 to 80 of about 1,022,044 (272)
Rainwater harvesting is a common practice in several parts of the world. It can be used for very diverse purposes, such as human consumption, livestock and agricultural production, and flood control. A rainwater harvesting system is conceived when a catchment surface is connected to a storage reservoir.
Galvão, Carlos de Oliveira +2 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Damage Caused by Wheeled Skidders on Cambisols of Central Europe
Croatian Journal of Forest Engineering, 2015 Machine traffic and timber skidding significantly affect the soil surface and soil properties. The effects are mostly negative and result in soil erosion, worsening of soil properties and inhibition of the growth of roots and soil organisms.
Michal Ferenčík +4 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of workplace injuries in Slovakian state forestry enterprises
Open Engineering, 2019 The aim of the paper is to identify the most common workplace accidents regarding injured body parts with respect to anthropometric data measurements of the population in the Slovak republic.
Gejdoš Miloš, Vlčková Mária
doaj +1 more source
Fluid-solid-electric lock-in of energy-harvesting piezoelectric flags
, 2014 The spontaneous flapping of a flag in a steady flow can be used to power an output circuit using piezoelectric elements positioned at its surface. Here, we study numerically the effect of inductive circuits on the dynamics of this fluid-solid-electric ...
Doare, Olivier +2 more
core +4 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Exposing and harvesting metadata using the OAI metadata harvesting protocol: A tutorial [PDF]
, 2001 In this article I outline the ideas behind the Open Archives Initiative metadata harvesting protocol (OAIMH), and attempt to clarify some common misconceptions. I then consider how the OAIMH protocol can be used to expose and harvest metadata.
Warner, Simeon
core +1 more source
The effect of non-uniform damping on flutter in axial flow and energy harvesting strategies
, 2012 The problem of energy harvesting from flutter instabilities in flexible slender structures in axial flows is considered. In a recent study, we used a reduced order theoretical model of such a system to demonstrate the feasibility for harvesting energy ...
Boyd J. +4 more
core +3 more sources