Results 81 to 90 of about 1,022,044 (272)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Assessing the influence of ground-based LiDAR devices, processing solutions, and forest stand characteristics on tree diameter and height estimation

Central European Forestry Journal
Diameter at breast height (DBH) and tree height (TH) are essential parameters for accurately estimating tree volume, biomass, and other forest metrics. Conventional measurement methods often involve considerable time investment, which has motivated the ...
Výbošťok Jozef, Chudá Juliána, Skladan Michal, Tomčík Daniel, Singh Arunima, Mokroš Martin   +5 more
doaj   +1 more source

Choosing the right close-range technology for measuring DBH in fast-growing trees plantations

Trees, Forests and People
Recently, the cultivation of fast-growing tree (FGT) plantations has gained importance due to the growing energy and climate crisis. FGT plantations have the potential to reduce carbon footprints and lower greenhouse gas emissions by utilization of local
Michal Skladan, Juliána Chudá, Arunima Singh, Matej Masný, Martin Lieskovský, Michal Pástor, Martin Mokroš, Jozef Vyboštok   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Preparation and characterization of ball milled chicken eggshell derived activated carbon (ACESP) / halloysite nanotubes (HNT) / fluorescein (FL) nanocomposite [BACHFL] as novel fluorescent probe for heavy metal ion detection

Next Materials
Mercury is considered as the most hazardous pollutant due to its adverse effects to mankind. Hence the present work aims at the preparation and characterization of ball milled chicken eggshell derived activated carbon (ACESP) / halloysite nanotubes (HNT)
Jeya M. Peter Paul, Bhuvaneshwari Ramasamy, Kannan Raman, Rajashabala Sundaram   +3 more
doaj   +1 more source

Electro-hydrodynamic synchronization of piezoelectric flags

, 2016
Hydrodynamic coupling of flexible flags in axial flows may profoundly influence their flapping dynamics, in particular driving their synchronization. This work investigates the effect of such coupling on the harvesting efficiency of coupled piezoelectric
Doare, Olivier, Michelin, Sebastien, Xia, Yifan   +2 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Combinatory Finite Element and Artificial Neural Network Model for Predicting Performance of Thermoelectric Generator

Energies, 2018
Thermoelectric generators (TEGs) are rapidly becoming the mainstream technology for converting thermal energy into electrical energy. The rise in the continuous deployment of TEGs is related to advancements in materials, figure of merit, and methods for ...
Ravi Anant Kishore, Roop L. Mahajan, Shashank Priya   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source