Results 91 to 100 of about 754,400 (287)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

THE EFFECT OF THE METHOD OF PLANTATION ESTABLISHMENT AND HARVESTING TIME ON SOME MORPHOLOGICAL FEATURES OF PLANTS AND ESSENTIAL OIL CONTENT IN LOVAGE ROOTS (Levisticum officinale Koch.)

Acta Scientiarum Polonorum: Hortorum Cultus, 2007
The field studies were carried out in 2002–2004 on brown soil of loess origin. In the experiment the following methods of plantation establishment were compared: direct sowing in the field (control); direct sowing in the field with cover of ...
Sylwia Andruszczak
doaj  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Effects of Harvesting Time on Fruit Development Process and Oil Content of Selected Iranian and Foreign Olive Cultivars under Subtropical Conditions. [PDF]

Plants (Basel), 2023
Fahadi Hoveizeh N, Gholami R, Zahedi SM, Gholami H, Carillo P.   +4 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Evaluation of the Productivity and Potential Utilization of Artemisia dubia Plant Biomass for Energy Conversion

Plants
Field studies with the large-stemmed plant Artemisia dubia (A. dubia) have been carried out at the Vėžaičiai Branch of LAMMC since 2018. According to three years of experimental results, annual dry matter (DM) yield varied from 7.94 to 10.14 t ha−1 ...
Algirdas Jasinskas, Gintaras Šiaudinis, Danutė Karčauskienė, Renata-Marks Bielska, Marek Marks, Stanislaw Bielski, Ramūnas Mieldažys, Kęstutis Romaneckas, Egidijus Šarauskis   +8 more
doaj   +1 more source

NMR-Based Metabolomic Approach for Evaluation of the Harvesting Time and Cooking Characteristics of Different Cassava Genotypes. [PDF]

Foods, 2022
Silva LMA, Alves Filho EG, Martins RM, Oliveira WJDJ, Vidal CS, de Oliveira LA, de Brito ES.   +6 more
europepmc   +1 more source

Precise space–time positioning for entanglement harvesting

New Journal of Physics, 2016
We explore the crucial role of relative space-time positioning between the two detectors in an operational two-party entanglement-harvesting protocol. Specifically we show that the protocol is robust if imprecision in spatial positioning and clock synchronization are much smaller than the spatial separation between the detectors and its light-crossing ...
Eduardo Martín-Martínez, Barry C Sanders   +1 more
openaire   +4 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source