Results 71 to 80 of about 754,400 (287)

A time for growth, maturation and harvest [PDF]

Journal of Public Health, 2010
Editorial
Leung, GM, Gray, S
openaire   +4 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

HARVEST PLANNING UNDER UNCERTAIN EXTINCTION TIME [PDF]

Natural Resource Modeling, 1999
ABSTRACT. Harvesting a targeted commercial species results in impacts on an endangered species which may have no direct market value but may need protection as mandated by environmental laws. A vigorous harvest path might drive the endangered species to extinction.
openaire   +1 more source

Exciton coupling induces vibronic hyperchromism in light-harvesting complexes

, 2014
The recently suggested possibility that weak vibronic transitions can be excitonically enhanced in light-harvesting complexes is studied in detail.
Kuehn, Oliver, Lund University., Pullerits, Tönu,, Schulze, Jan, Torbjörnsson, Magne,   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Content of Prussic Acid and Production of Sorghum Brown Midrib by Adding Urea Fertilizer and Extending Harvesting Time

Animal Production: Indonesian Journal of Animal Production, 2019
. The aimed of this study to determine the effect of adding urea fertilizer (0, 50, and 100 kg/ha) and harvesting time (50, 80 and days) on prussic acid content and production of the brown midrib (BMR) sorghum plants.
Nafiatul Umami, Nofi Isnaini, Bambang Suhartanto   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Computational Methodologies and Physical Insights into Electronic Energy Transfer in Photosynthetic Light-Harvesting Complexes

, 2012
We examine computational techniques and methodologies currently in use to explore electronic excitation energy transfer in the context of light-harvesting complexes in photosynthetic antenna systems, and comment on some new insights into the underlying ...
Adolphs, Aslangul, Barone, Blankenship, Bonella, Bonella, Breuer, Briggs, Caldeira, Cao, Cheng, Cheng, Collini, Curutchet, Curutchet, Damjanović, Dekker, Dittrich, Dittrich, Dunkel, Eckel, Elran, Engel, Fassioli, Fleming, Ford, Ford, Ford, Ford, Franco, Franco, Förster, Galve, Gedanken, Gilmore, Gilmore, Gilmore, Gorini, Grabert, Grabert, Haake, Habenicht, Haken, Hanson, Hoki, Hoki, Hoyer, Huo, Huo, Huo, Hwang, Hwang, Ishizaki, Ishizaki, Ishizaki, Jang, Jiang, Jing, König, Lee, Leggett, Leonardo A. Pachón, Lindblad, Makri, Makri, Mančal, Martín-Delgado, Mennucci, Mercer, Meyera, Mirkovic, Moix, Moll, Müh, Nakajima, Nalbach, Nalbach, Nalbach, Nazir, Nemeth, Novoderezhkin, Olaya-Castro, Olaya-Castro, Olbrich, Olbrich, Olbrich, Olbrich, Pachón, Pachón, Panitchayangkoon, Paul Brumer, Pengfei, Petta, Plenio, Prezhdo, Prezhdo, Prior, Ratner, Rebentrost, Redfield, Renger, Ritschel, Ritschel, Ritschel, Rivas, Salverda, Schlau-Cohen, Schmidt am Busch, Scholes, Scholes, Shibata, Shim, Singh, Stock, Stockburger, Strümpfer, Sundström, Tao, Thorwart, Thoss, Thoss, Tomasi, Tronrud, Turner, Vedral, Weiss, Wu, Yu, Zhu, Zwanzig, Zwanzig   +130 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source