The restricted mean survival time as a replacement for the hazard ratio and the number needed to treat in long-term studies. [PDF]
ESC Heart Fail, 2021 Messori A, Bartoli L, Trippoli S.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Review of: "Risk of death derived from Hazard Ratio should not be communicated as Relative Risk reductions for death in cancer clinical trials. Intentional or inadvertent?" [PDF]
, 2023 Ping Sun
openalex +1 more source
Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate. [PDF]
BMC Med Res Methodol, 2021 MacKenzie TA +2 more
europepmc +1 more source
Institutions, Bargaining Power and Labor Shares [PDF]
We use a static framework characterized by both moral hazard and holdup problems. In the model the optimal allocation of bargaining power balances these frictions.
Benjamin Bental, Dominique Demougin
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints. [PDF]
BMC Med Res Methodol, 2021 Cortés Martínez J +3 more
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Experience of Crisis-Hit Asian Countries: Do Asset Management Companies Increase Moral Hazard? [PDF]
This paper examines the performances of Asian asset management companies (AMCs). The analysis reveals that the AMCs vary significantly in their design and performances.
Pasadilla, Gloria +1 more
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