HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients [PDF]
BMC Gastroenterology, 2023 Background Previous studies have indicated that HBV pregenome RNA (HBV pgRNA) could predict HBeAg seroconversion among the chronic hapatitis B (CHB) patients treated with pegylated interferon (Peg-IFN) or nucleos(t)ide analogues (NAs).
Guangjun Song +6 more
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Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α [PDF]
Therapeutic Advances in GastroenterologyBackground: As an uncommon serological pattern, the effect of hepatitis B e antigen/anti-hepatitis B e (HBeAg/anti-HBe) coexistence on peginterferon-α (Peg-IFN-α) therapy in patients with chronic hepatitis B (CHB) remains unknown.
Kaimin Song +9 more
doaj +4 more sources
Efficacy of a combination of HBV RNA and HBeAg in predicting HBeAg seroconversion in patients treated with entecavir for 144 weeks [PDF]
International Journal of Infectious Diseases, 2020 Background: In some previous studies, serum hepatitis B virus RNA (HBV RNA) was proposed as an HBV viral marker during therapy. However, the dynamic change of HBV RNA, the correlation of HBV RNA with cccDNA, and the combination of HBV RNA with known HBV ...
Xiaomei Wang +24 more
doaj +5 more sources
HBcrAg Identifies Patients Failing to Achieve HBeAg Seroconversion Treated with Pegylated Interferon Alfa-2b [PDF]
Chinese Medical Journal, 2016 Background: We aimed to evaluate the usefulness of serum hepatitis B virus core-related antigens (HBcrAg) for predicting hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive chronic hepatitis B patients treated with conventional interferon (IFN)
Hui Ma +4 more
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Meta-omics characteristics of intestinal microbiota associated to HBeAg seroconversion induced by oral antiviral therapy [PDF]
Scientific Reports, 2021 Tenofovir and entecavir are currently designated as the preferred oral antiviral drugs for chronic hepatitis B. However, only less than 40% of patients can achieve HBeAg seroconversion.
Yu-Li Zeng +15 more
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The presence of baseline HBsAb-Specific B cells can predict HBsAg or HBeAg seroconversion of chronic hepatitis B on treatment [PDF]
Emerging Microbes and Infections, 2023 Indices for predicting HBsAg or HBeAg seroconversion in patients with chronic hepatitis B virus (HBV) infection during antiviral therapy remain elusive.
Shengxia Yin +15 more
doaj +2 more sources
Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion. [PDF]
Emerg Microbes Infect, 2018 Hepatitis B virus (HBV) integration into the host cell genome occurs early on in infection and reportedly induces pro-oncogenic changes in hepatocytes that drive HCC initiation. However, it remains unclear when these changes occur during hepatocarcinogenesis.
Budzinska MA, Shackel NA, Urban S, Tu T.
europepmc +4 more sources
Peripheral and intrahepatic B-cell subsets contribute to HBeAg seroconversion in patients with chronic hepatitis B [PDF]
Virology JournalThe immunopathogenesis of chronic hepatitis B (CHB) with unclear immune phases hinders functional cure. For highly infectious HBeAg-positive (HBeAg+) patients where functional cure is unattainable, achieving sustained HBeAg seroconversion constitutes the
Jing Zuo +6 more
doaj +2 more sources
Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa-2a [PDF]
Virology Journal, 2019 Background Hepatitis B e antigen (HBeAg) seroconversion represents an endpoint of treatment of chronic hepatitis B virus (HBV) infections. Methods We have studied whether levels of serum hepatitis B virus ribonucleic acid (HBV RNA) during pegylated ...
Wen Jia +8 more
doaj +2 more sources
HBV-miR-3 is closely related to HBV replication and strongly predictive of HBeAg seroconversion in PegIFN-α treated patients [PDF]
Scientific ReportsHBV-miR-3 is encoded by HBV and takes part in pathogenesis of HBV-related liver disease. Whether HBV-miR-3 has a relationship with HBV replication and is predictive of PegIFN-α treatment response is still unknown. HBV-miR-3 quantification is based on qRT-
Zhenyu Xu +6 more
doaj +2 more sources