Results 101 to 110 of about 132,691 (312)
International Journal of General Medicine, 2021 Mekuanint Geta,1 Endalew Yizengaw,2 Zegeye Getaneh,3 Tamyalew Getahun4 1Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Departments of ...
Geta M, Yizengaw E, Getaneh Z, Getahun T
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Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux +6 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.We used an administrative claims dataset to evaluate the relationship between hepatitis B virus (HBV) low‐level viraemia and subsequent liver‐related outcomes in patients with chronic HBV. We found that individuals with HBV low‐level viraemia have an increased risk for liver‐related events (i.e., cirrhosis, decompensation, and hepatocellular carcinoma)
Paul Y. Kwo +11 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Bulevirtide increases bile acid levels in most patients; however, changes in bile acids do not predict virological response or adverse events, nor do they reflect treatment adherence. After discontinuation of bulevirtide, bile acid levels rapidly decline.
Marlene Hintersteininger +14 more
wiley +1 more source
Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia
Haemophilia, EarlyView.ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh +5 more
wiley +1 more source
Hepatology Research, EarlyView.In a population‐based cohort in Japan, HBV reactivation‐related events were observed after HBsAg seroclearance, including one virologically confirmed hepatic flare occurring spontaneously without chemotherapy or immunosuppression. These findings indicate that HBsAg seroclearance does not always represent complete viral eradication, supporting the need ...
Kazumi Yamasaki +7 more
wiley +1 more source
Hepatology Research, EarlyView.Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami +15 more
wiley +1 more source
Hepatology Research, EarlyView.ABSTRACT Aim Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major causes of liver‐related morbidity and mortality worldwide. Although Japan has implemented nationwide screening and treatment programs for decades, updated nationwide estimates and long‐term projections are limited.
Junko Tanaka +4 more
wiley +1 more source
Toward a Functional Cure for Chronic Hepatitis B: Current Landscape and Future Directions in Japan
Hepatology Research, EarlyView.Hepatitis B is a viral liver infection that can become chronic, increasing the risk of developing liver cancer and liver failure. Because current treatments rarely cure these problems, researchers are now focusing on a functional cure in which the virus becomes undetectable in blood and stays that way, even after the treatment ends.
Yutaka Handa +2 more
wiley +1 more source