Results 81 to 90 of about 60,915 (280)

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

A rational approach to the development of future generation processes for lipoprotein VLP vaccine candidates

, 2009
Lipoprotein VLPs, known also as lipid-envelope VLPs, are expressed intracellularly in yeast, localised on the host endoplasmic reticulum (ER). The main challenge in production lies in the complexity of the recovery and purification process.
Kee, G.K.
core  

Presence of hepatitis B surface antigen (HBsAg)-specific cytotoxic T cells in asymptomatic HBsAg carriers

, 1994
To investigate whether there is any evidence of an immune stimulation against hepatitis B virus surface antigen (HBsAg) in asymptomatic HBsAg carriers, proliferative and cytotoxic re-sponses to HBsAg were measured in their peripheral blood lymphocytes ...
Cheng-po Hu, Chungming Chang, L.-H. Hwang, Lih-hwa Hwang, M.-Y. Lin, C. Chang, Jyh-hsiung Huang, P.-Y. Shu, J.-H. Huang, Meei-yun Lin, Tong-hsuan Chang, Pei-yun Shu, C.-p. Hu, T.-H. Chang   +13 more
core   +1 more source

Sporadic Hepatocellular Carcinoma in an Adolescent Harboring a Somatic CDH1 Mutation: A Case Report and Literature Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chang‐Wei Su, Peir‐In Liang, Shih‐Chang Chuang   +2 more
wiley   +1 more source

Updated Burden and Long‐Term Projections of Chronic Hepatitis B and C in Japan: A Nationwide Markov Modeling Study

Hepatology Research, EarlyView.
ABSTRACT Aim Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major causes of liver‐related morbidity and mortality worldwide. Although Japan has implemented nationwide screening and treatment programs for decades, updated nationwide estimates and long‐term projections are limited.
Junko Tanaka, Akemi Kurisu, Ko Ko, Aya Sugiyama, Tomoyuki Akita   +4 more
wiley   +1 more source

Risk Stratification of Hepatocellular Carcinoma in Hepatitis B Virus e Antigen-Negative Carriers by Combining Viral Biomarkers

, 2014
Background. The serum hepatitis B virus (HBV) surface antigen (HBsAg) level can predict hepatocellular carcinoma (HCC) development in hepatitis B e antigen (HBeAg)-negative patients with an HBV DNA level of <2000 IU/mL.
Tseng, Tai-Chung;Liu, Chun-Jen;Chen, Chi-Ling;Yang, Hung-Chih;Su, Tung-Hung;Wang, Chia-Chi;Yang, Wan-Ting;Kuo, Stephanie Fang-Tzu;Liu, Chen-Hua;Chen, Pei-Jer;Chen, Ding-Shinn;Kao, Jia-Horng, 陳定信 ;劉振驊 ;高嘉宏 ;楊宏志 ;劉俊人 ;陳培哲 ;陳祈玲   +1 more
core  

Can HBsAg Be Used as a Viral Replication Marker in Chronic Hepatitis B Patients?

, 2017
Objective: Monitoring hepatitis B virus (HBV) treatment responses and virus replication is performed with molecular tests. However, these tests are either expensive or invasive. A new and more practical marker is needed.
Hakan KUTLU, Esin AVCI, ahin, Ahmet Melih, Gökçe GÜNTEPE, Uzuno lu, Emel, Kutlu, Hakan, Emel UZUNOĞLU, Ahmet Melih ŞAHİN, Avc , Esin, Güntepe, Gökçe   +9 more
core   +1 more source

Toward a Synthetic Data Revolution: Diffusion Model‐Enhanced Hepatocellular Carcinoma Prediction in Steatotic Liver Disease

Hepatology Research, EarlyView.
ABSTRACT Aim Steatotic liver disease (SLD) encompasses a heterogeneous spectrum with varying risks of hepatocellular carcinoma (HCC). Limited sample sizes limit the development of predictive models, particularly for rare outcomes. This study evaluated whether generative artificial intelligence (AI)‐based synthetic data augmentation can enhance HCC risk
Masaya Sato, Takuma Nakatsuka, Yuki Matsushita, Takuma Kaneko, Keisuke Mabuchi, Tomoharu Yamada, Kazuya Okushin, Tatsuya Minami, Yotaro Kudo, Satoshi Kodera, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi   +12 more
wiley   +1 more source

Erlerde HBSAG pozitifliği

, 2015
investigate the HBsAg positivity in soldiers.Sera were taken from soldiers and HBsAg positivity was investigated by using solid-phase dot EIA method. We found the HBsAg positivity rate to be 6.2 % ( 149 / 2400) Despite the availability of vaccines for more than 15 years, hepatitis B virus (HBV) infection continues to be an important public health ...
Yegane Tosun, Selma, Özbakkaloğlu, Beril, Şahin, Ahmet   +2 more
openaire   +2 more sources

Use of HBSAG Quantification To Guide HBIG Prophylaxis After Liver Transplantation

, 2014
Hepatitis B surface antigen (HBsAg) quantification has recently been introduced to guide treatment in chronic hepatitis B virus (HBV) patients.
Silvestri A, Ghinolfi D, Precisi A, Alessandro Silvestri, Leonardi G, Filipponi F., Davide Ghinolfi, Paola Carrai, Arianna Precisi, Carrai P, Paolo De Simone, Giulia Leonardi, Campani D, Franco Filipponi, De Simone P, Daniela Campani   +15 more
core   +1 more source