Results 91 to 100 of about 132,691 (312)

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Construction of bicistronic cassette for co-expressing hepatitis B surface antigen and mouse granulocyte-macrophage colony stimulating factor as adjuvant in tobacco plant

Pharmaceutical Biology, 2019
Context: The co-delivery of adjuvant and antigen has shown to be more effective for targeting the immune response than antigen alone. Therefore, designing an efficient bicistronic system is more assuring for production of both elements in the same ...
Sara Mohammadzadeh, Hamideh Ofoghi, Mina Ebrahimi-Rad, Parastoo Ehsani   +3 more
doaj   +1 more source

HBsAg clearance and seroconversion case in a patient with HBeAg-negative chronic hepatitis B on pegylated interferon α-2a therapy

Журнал инфектологии, 2014
Presented clinical case describes elimination followed by seroconversion HBsAg / HBsAb patient with HBeAg-negative chronic hepatitis B on antiviral therapy with pegylated interferon α2-a and achieving sustained virological response.
K. V. Zhdanov, D. A. Gusev, K. V. Kozlov, S. S. Zhabrov, A. V. Shekurov, A. V. Nagovitsyn, A. V. Mishin, E. V. Jakovleva   +7 more
doaj   +1 more source

IL28B is associated with outcomes of chronic HBV infection [PDF]

, 2015
Purpose The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes.
Chi, Xiumei, Gao, Yanhang, Jiang, Jing, Li, Wanyu, Minuk, Gerald, Niu, Junqi, Pan, Yu, Shi, Xiaodong, Xu, Damo, Yang, Chen, Zhang, Manna, Zhong, Jin   +11 more
core   +1 more source

The Safety of Interferon‐Based Therapies in Chronic Hepatitis B Patients With Compensatory Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
While nucleos(t)ide analog (Nuc) therapy is the standard for chronic hepatitis B, pegylated interferon‐alpha (Peg‐IFN‐α) provides unique advantages, including finite treatment duration and long‐term benefits. However, its use in patients with compensated cirrhosis remains limited due to persistent safety concerns about potential decompensation and ...
Qiran Zhang, Taoran Geng, Ruirui You, Huiling Xiang, Ying Guo, Xiaohong Gao, Guojun Li, Qun Zhang, Xiaoping Wu, Haifang Cao, Wenhua Zhang, Jia Shang, Jiawei Geng, Lihong Qu, Shuilin Sun, Xiulan Xue, Rui Zhao, Lihua Zhong, Guohong Ge, Yanbin Wang, Jianqi Lian, Ming Liang, Qing Ye, Xiaoyan Wang, Xiaoqing Guo, Dan Xu, Yiqi Yu, Feng Sun, Chao Qiu, Jiming Zhang, Yuxian Huang, Wenhong Zhang, Xiaolong Qi   +32 more
wiley   +1 more source

Hepatitis B Virus Infection and Associated Factors Among Adults in Southwest Ethiopia: Community-Based Cross-Sectional Study

International Journal of General Medicine, 2020
Alemayehu Sayih Belay,1 Dejene Derseh Abateneh,1,2 Sisay Shewasinad Yehualashet,1,3 Kindie Mitiku Kebede1 1Mizan Tepi University, College of Health Sciences, Mizan Aman, Ethiopia; 2Kotebe Metropolitan University, Menelik II College of Medicine and Health
Belay AS, Abateneh DD, Yehualashet SS, Kebede KM   +3 more
doaj  

Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]

, 1985
A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George, Christman, Judith K., Kent, Stephen B. H., Neurath, A. Robert, Offensperger, Wolf, Price, Peter, Strick, Nathan, Wahl, Silke   +7 more
core   +1 more source

Incidence and predictors of HBV relapse after cessation of nucleoside analogues in HBeAg-negative patients with HBsAg ≤ 200 IU/mL

Scientific Reports, 2017
The predictors of hepatitis B virus (HBV) relapse and HBsAg loss after cessation of nucleos(t)ide analogues (NA) in HBeAg-negative patients with end-of-treatment HBsAg ≤ 200 IU/mL remains unclear.
Chih-Chien Yao, Chao-Hung Hung, Tsung‐Hui Hu, Sheng-Nan Lu, Jing-Hung Wang, Chun-Mo Lee, Chien-Hung Chen   +6 more
semanticscholar   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Prevalence of Hepatitis B Virus among Pregnant Women Attending Antenatal Care in Alexandria

Journal of High Institute of Public Health, 2019
Background & Hepatitis B infection is a very serious public health problem. Perinatal vertical transmission is a common mode of transmission. Infants infected from their mothers will have a very high risk of developing chronic liver disease. Objective(s):
Marwa M. Fekry, Mona H. Hashish, Heba S. Selim, Abdel-Moneim Fawzy, Marwa M. Wahba   +4 more
doaj   +1 more source