Results 11 to 20 of about 780 (113)

Adaptive Evolution and Distinct Mutation Signatures of Full-Length HBV Quasispecies in HBeAg-Negative Chronic Hepatitis B. [PDF]

Microbiologyopen
HBeAg‐negative chronic hepatitis B harbors a highly heterogeneous HBV quasispecies shaped by region‐specific selection. Adaptive strategies underpinning viral persistence include: BCP/PreC mutations supporting replication, PreS/S mutations enabling immune evasion, and overlapping Pol/S mutations maintaining viral fitness.
Wu C, Liu F, Li X, Li X, Li H, Zhang S, Yan X, Zhou T, Wei J.   +8 more
europepmc   +2 more sources

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Boivin-Champeaux C, Velez de Mendizabal N, Jones A, Balsitis S, Schmidt S, Feigelman JS, Azeredo FJ.   +6 more
europepmc   +2 more sources

Sulforaphane effectively inhibits HBV by altering Treg/Th17 immune balance and the MIF-macrophages polarizing axis in vitro and in vivo [PDF]

Virus Research
Background: Hepatitis B virus (HBV) infection is a major public health problem. After HBV infection, viral antigens shift the immune balance in favor of viral escape.
Ruqing Xu, Yue Wu, Xia Xiang, Xiaoqin Lv, Miao He, Chang Xu, Guoqi Lai, Tingxiu Xiang   +7 more
doaj   +2 more sources

Consolidation treatment needed for sustained HBsAg-negative response induced by interferon-alpha in HBeAg positive chronic hepatitis B patients [PDF]

Virologica Sinica, 2022
Minghui Li, Xiaoyue Bi, Yao Lu
exaly   +2 more sources

Hepatitis B Virus Reactivation with Discontinuation of Nucleoside Analogue in Patients Who Received Allogeneic Hematopoietic Stem Cell Transplantation

Case Reports in Gastroenterology, 2021
Reactivation of hepatitis B virus (HBV) is known to occur frequently after hematopoietic stem cell transplantation (HSCT). The reactivation can be prevented by nucleos(t)ide analogue (NA), but it is unclear how long NA should be continued.
Mio Tsuruoka, Jun Inoue, Yasushi Onishi, Masashi Ninomiya, Eiji Kakazu, Tomoaki Iwata, Akitoshi Sano, Kosuke Sato, Hideo Harigae, Atsushi Masamune   +9 more
doaj   +1 more source

Reactivation of hepatitis B virus in HBsAg-negative patients with hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Despite increasing attention to hepatitis B virus (HBV) reactivation in hematologic settings, information on reactivation in hepatitis B surface (HBsAg)-negative patients with hepatocellular carcinoma (HCC) remains unknown.
Jeong Won Jang, Young Woon Kim, Sung Won Lee, Jung Hyun Kwon, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Kyu Won Chung   +8 more
doaj   +1 more source

Assessment of Liver Morbidity in Breast Cancer Patients Receiving Chemotherapy in Suez Canal University Hospitals [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2019
Background and study aim: In Egypt, breast cancer, representing 18.9% of total cancer cases and 35.1% of cancer in women. Potential interactions between the liver and chemotherapy fall into direct chemotherapy-induced hepatotoxicity and Potentiation of ...
Ehab Hassanein, Adel Hassan, Mahmoud Sheded   +2 more
doaj   +1 more source

A sensitive single reverse passive haemagglutination test for detecting both HBsAg and anti-HBs. [PDF]

Journal of Clinical Pathology, 1979
A trial of a modified reverse passive haemagglutination test for HBsAg using a 0.1% cell suspension instead of the recommended 1% showed an approximately eight-fold increase in detection sensitivity. The test can be performed within 30 minutes and lends itself to mass screening techniques. Confirmation tests can be done using the 0.1% method.
J A, Barbara, P J, Harrison, D R, Howell, T E, Cleghorn, D S, Dane, M, Briggs, C H, Cameron   +6 more
openaire   +2 more sources

Seroreversion and Acute Decompensation in Chronic Hepatitis B after Discontinuation of Oral Nucleotide Analog in the Patients Achieving HBsAg Loss

The Korean Journal of Gastroenterology, 2020
Although rare patients with chronic hepatitis B can achieve HBsAg loss on oral nucleos(t)ide analog (NA), the optimal timing of stopping oral NAs safely has been considered when HBsAg and HBV DNA are negative in the serum because HBsAg loss induced by ...
Hye Jeong Cho, Seung Kak Shin, Oh Sang Kwon, Ju Hyun Kim, Yun Soo Kim   +4 more
doaj   +1 more source

Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients [PDF]

Cellular & Molecular Immunology, 2015
B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB ...
Xiangsheng, Xu, Qinghua, Shang, Xinyue, Chen, Weimin, Nie, Zhengsheng, Zou, Ang, Huang, Ming, Meng, Lei, Jin, Ruonan, Xu, Ji-Yuan, Zhang, Junliang, Fu, Lifeng, Wang, Zirong, Tang, Yunbo, Xie, Xiaoming, Yang, Zheng, Zhang, Fu-Sheng, Wang   +16 more
openaire   +2 more sources