Results 31 to 40 of about 780 (113)

Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2

open access: yesInfection, Genetics and Evolution, 2016
Hepatitis B virus (HBV) subgenotype B2 is prevalent in China and some other parts of Asia. This study aimed to carry out a subgenotype B2 specific mutation analysis on important amino acid (AA) sites in overlapping reverse transcriptase (RT) and surface (S) protein coding regions of HBV.A total of 143 hepatitis B e antigen (HBeAg)-positive chronic ...
Mingze Su   +8 more
openaire   +2 more sources

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

open access: yesJournal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego   +7 more
wiley   +1 more source

Hepatitis B Reactivation in Biologic‐Treated Moderate‐to‐Severe Psoriasis: A Real‐World Cohort Study With 534 Patient‐Years of Follow‐Up

open access: yesDermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Psoriasis vulgaris is a chronic immune‐mediated inflammatory disease frequently requiring long‐term biologic therapy. Although biologics targeting TNF‐α and interleukin pathways have revolutionized disease management, they may disrupt antiviral immune surveillance and trigger hepatitis B virus (HBV) reactivation in individuals with prior HBV
Neslihan Demirel Öğüt   +7 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

open access: yesMedicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro   +5 more
wiley   +1 more source

Glycosylated Foot‐And‐Mouth Disease Virus‐Like Particles Produced in Pichia Pastoris Enhance Stability and Immunogenicity

open access: yesMicrobial Biotechnology, Volume 18, Issue 11, November 2025.
An N‐glycosylation was strategically introduced at the 166th position of VP1 via artificial mutagenesis. The glycans mainly consist of high‐mannose type, significantly enhancing the stability and uptake of VLPs. The glycosylated VLPs conferred a robust Th1‐type immune response in mice and pigs and provided 100% protection against FMDV in pigs ...
Zhiyao Li   +10 more
wiley   +1 more source

From Lab to Market: Paper‐Based CRISPR Diagnostics and Commercialization Pathways

open access: yesAdvanced Sensor Research, Volume 4, Issue 10, October 2025.
Paper‐based CRISPR diagnostics represents one of the most widely commercialized CRISPR assay technologies, yet challenges remain for broader point‐of‐care use. Abstract The global health landscape is continually challenged by infectious diseases that can swiftly escalate into pandemics, underscoring the need for rapid, accurate, and cost‐effective ...
Selen Dalgan, Qingshan Wei
wiley   +1 more source

Reversed passive hemagglutination test fails to detect HBsAg in a number of HBeAg positive sera.

open access: yesAsian Pacific journal of allergy and immunology, 2003
In endemic areas of hepatitis B virus (HBV) infection, perinatal transmission from asymptomatic HBsAg carrier mothers to infants plays a major role in the transmission of HBV. HBeAg indicates a high level of viral replication and infectivity. Most of the infants born to HBeAg positive mothers become carriers.
Duangtawan, Thammanichanond   +3 more
openaire   +1 more source

Hepatitis B Virus in Jordan: Prevalence, Incidence and Clearance From Cross‐Sectional and Cohort Studies

open access: yesJournal of Viral Hepatitis, Volume 32, Issue 10, October 2025.
ABSTRACT Hepatitis B virus (HBV) infection is a global health challenge, with the World Health Organization (WHO) targeting its elimination by 2030. Jordan lacks sufficient data on HBV epidemiology, including prevalence, incidence and clearance. This study addresses these gaps through a retrospective analysis of HBV testing data from 40,268 individuals
Issa Abu‐Dayyeh   +6 more
wiley   +1 more source

Liver Involvement in Celiac Disease and Immune‐Mediated Diseases of the Small Bowel

open access: yesLiver International, Volume 45, Issue 8, August 2025.
ABSTRACT Disorders of the hepatobiliary system are commonly associated with gastrointestinal (GI) diseases. The GI and hepatobiliary systems interact through the portal vein system and enterohepatic circulation, creating a gut–liver axis that allows for a complex multidirectional interplay between immune, hormonal, dietary and environmental luminal ...
Nicoletta Nandi   +8 more
wiley   +1 more source

Hepatitis B Virus NAT Positive Donors in Non‐Hepatic Organ Transplant: Quantifying Viral Loads to Optimize Recipient Risk Stratification and Management in the Prevention of Donor‐Derived Infection

open access: yesClinical Transplantation, Volume 39, Issue 7, July 2025.
ABSTRACT Transplantation is one of the few life‐saving therapies for patients with end‐stage organ disease, yet organ availability remains restrictive. Expanding donors to include those with hepatitis B virus (HBV) infection, incorporating HBV nucleic acid amplification testing (NAT) positive donors, could improve organ access.
Patrick C. K. Tam   +7 more
wiley   +1 more source

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