Results 201 to 210 of about 333,660 (389)

A 15‐year population‐based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy

open access: yesPediatric Investigation, EarlyView.
Increasing incidence of pediatric inflammatory bowel disease (IBD) and suboptimal vaccination coverage in Apulia, Italy (2009–2023). A total of 1044 incident cases of paediatric IBD were identified in the period 2009–2023 in Apulia, Italy, giving an average annual standardized incidence rate of 12.7/100 000. A significant increase in incidence occurred
Francesca Fortunato   +4 more
wiley   +1 more source

Teachers' Response to a Student Presenting With Suicidality: A Call to Action

open access: yesPsychology in the Schools, EarlyView.
ABSTRACT Schools are a logical point of access for suicide prevention, assessment, and intervention services. Teachers serve as gatekeepers, uniquely positioned to identify suicide warning signs and refer students to appropriate services. Teachers often receive general mental health training but rarely extended or specialized suicide gatekeeper ...
Katherine A. Feather   +5 more
wiley   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux   +6 more
wiley   +1 more source

A Step‐by‐Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In silico clinical trials (ISCT) are computational frameworks that employ mathematical models to generate virtual patients and simulate their responses to new treatments, treatment regimens, or medical devices via simulations mirroring real‐world clinical trials.
Javiera Cortés‐Ríos   +4 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

open access: yesSmall Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles(LNPs)and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy