Results 1 to 10 of about 2,433,705 (252)

CRISPR/Cas13a-assisted rapid and portable HBV DNA detection for low-level viremia patients. [PDF]

Emerg Microbes Infect, 2023
Background & Aims The WHO declared to eliminate hepatitis B virus (HBV) by 2030. However, an increasing number of patients are presenting with low-level viremia (LLV) with the widespread use of antiviral medications.
Tian Y, Fan Z, Xu L, Cao Y, Chen S, Pan Z, Gao Y, Li H, Zheng S, Ma Y, Duan Z, Zhang X, Ren F.   +12 more
europepmc   +2 more sources

HBV‐RNA Co‐amplification May Influence HBV DNA Viral Load Determination

Hepatology Communications, 2020
Despite effective hepatitis B virus (HBV)‐DNA suppression, HBV RNA can circulate in patients receiving nucleoside/nucleotide analogues (NAs). Current assays quantify HBV DNA by either real‐time polymerase chain reaction (PCR), which uses DNA polymerase ...
Benjamin Maasoumy, Anna Maria Geretti, André Frontzek, Harrison Austin, Gudrun Aretzweiler, Monica Garcia‐Álvarez, Susanne Leuchter, Christian O. Simon, Ed G. Marins, Jesse A. Canchola, Markus Cornberg, Rafael Delgado, Heiner Wedemeyer   +12 more
doaj   +7 more sources

Exosomal HBV-DNA for diagnosis and treatment monitoring of chronic hepatitis B. [PDF]

Open Life Sci, 2023
This study examined exosomal hepatitis B virus (HBV)-DNA levels in chronic HBV infection (CHB). Patients were grouped according to the European Association for the Study of the Liver classification (1: HBV-DNA-positive CHB, normal alanine ...
Xu X, Zhang L, Liu J, Kong X, Yin Y, Jia Z, Zhang X, Peng B, Ji M, Pan W.   +9 more
europepmc   +2 more sources

The E3 Ubiquitin Ligase TRIM21 Promotes HBV DNA Polymerase Degradation

Viruses, 2020
The tripartite motif (TRIM) protein family is an E3 ubiquitin ligase family. Recent reports have indicated that some TRIM proteins have antiviral functions, especially against retroviruses.
Ting Mu, Xiaoqing Zhao, Yanan Zhu, Hongxia Fan, Hua Tang   +4 more
doaj   +2 more sources

Association between HBV DNA levels and bone mineral density in antiviral-naive chronic hepatitis B patients. [PDF]

Front Endocrinol (Lausanne)
ObjectivesRecent studies have shown that patients with chronic hepatitis B (CHB) have an increased prevalence of osteoporosis. However, the direct relationship between hepatitis B virus (HBV) DNA (representing the viral replication level) and bone ...
Zhou X, Jing X, Zu N, Li Z, Kong X, Wang S.   +5 more
europepmc   +2 more sources

HBV DNA polymerase regulates tumor cell glycogen to enhance the malignancy of HCC cells. [PDF]

Hepatol Commun
Background:. The essential function of HBV DNA polymerase (HBV-DNA-Pol) is to initiate viral replication by reverse transcription; however, the role of HBV-DNA-Pol in HBV-associated HCC has not been clarified.
Zhao X, Wang C, Zhao L, Tian Z.
europepmc   +2 more sources

Association between high HBV-DNA viral load and liver metastasis risk in patients with nasopharyngeal carcinoma [PDF]

Virus Res
A total of 976 patients with nasopharyngeal carcinoma (NPC) confirmed by pathology in Xiangya Cancer Hospital of Central South University from May 2017 to December 2022 were recruited for the study.
Wang X, Bao Y, Yin S, Peng Y.
europepmc   +2 more sources

APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription

Antiviral Research, 2018
Hepatitis B virus is a partially double-stranded DNA virus that replicates by reverse transcription, which occurs within viral core particles in the cytoplasm. The cytidine deaminase APOBEC3B is a cellular restriction factor for HBV. Recently, it was reported that APOBEC3B can edit HBV cccDNA in the nucleus, causing its degradation.
Yanmeng Chen, Jie-Li Hu, X. Cai, Yao Huang, Xingru Zhou, Z. Tu, Jie-Li Hu, J. Tavis, N. Tang, A. Huang, Yuan Hu   +10 more
semanticscholar   +3 more sources

Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. [PDF]

Virol Sin
The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC)] remains unclear.
Yang Z, Zeng J, Chen Y, Wang M, Luo H, Huang AL, Deng H, Hu Y.   +7 more
europepmc   +3 more sources

Coexisting patterns and significance of serum HBV RNA and HBV DNA in patients with treatment-naïve chronic hepatitis B virus infection. [PDF]

Front Med (Lausanne)
AimThe study aimed to explore the coexisting patterns and assess the significance of serum hepatitis B virus (HBV) RNA and traditional virological biomarkers in patients with antiviral treatment-naïve chronic hepatitis B virus (HBV) infection ...
Hao KY, Fan Y, Zhang YQ, Yu YC.
europepmc   +2 more sources