Results 31 to 40 of about 2,442,539 (329)

Highly sensitive and specific detection of HBV DNA and drug resistance mutations utilizing the PCR-based CRISPR-Cas13a system.

Clinical Microbiology and Infection, 2020
OBJECTIVES Undetectable or low-level hepatitis B virus (HBV) DNA and drug resistance mutations in patients may increase the risk of HBV transmission or cause active viral replication and other clinical problems.
Shan Wang, Hao Li, Z. Kou, F. Ren, Yi Jin, Lang Yang, Xue Dong, Mingjuan Yang, Jiangyun Zhao, Hongbo Liu, Nian Dong, L. Jia, Xinyue Chen, Yusen Zhou, S. Qiu, Rongzhang Hao, Hongbin Song   +16 more
semanticscholar   +1 more source

Persistence of extrahepatic hepatitis B virus DNA in the absence of detectable hepatic replication in patients with baboon liver transplants [PDF]

, 1995
The presence of hepatitis B virus (HBV) DNA in extrahepatic tissues has been well documented. Whether HBV DNA can persist in extrahepatic tissues for long periods of time in the absence of replication in the liver has not been determined previously ...
Davidson, Dejean, Hadchouel, Halpern, Hosoda, Jilbert, Korba, Korba, Lake, Lamelin, Lazizi, Leung, Mason, Mason, Perrillo, Pontisso, Starzl, Starzl, Todo, Yoffe   +19 more
core   +1 more source

Reactivation of hepatitis B virus with immune-escape mutations after ocrelizumab treatment for multiple sclerosis [PDF]

, 2019
Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS) that is closely related to rituximab. We describe a case of hepatitis B virus (HBV) reactivation in an MS patient with resolved HBV infection receiving ...
Altieri, Marta, Annecca, Rosanna, Aragri, Marianna, Ciardi, Maria R, Iannetta, Marco, Mastroianni, Claudio M, Pontecorvo, Simona, Russo, Gianluca, Salpini, Romina, Svicher, Valentina, Vullo, Vincenzo, Zingaropoli, Maria A   +11 more
core   +1 more source

Association of mutations in the basal core promoter and pre-core regions of the hepatitis B viral genome and longitudinal changes in HBV level in HBEAG negative individuals: Results from a cohort study in northern Iran [PDF]

, 2015
Background: Although certain HBV mutations are known to affect the expression of Hepatitis e antigen, their association with HBV viral level or clinical outcomes is less clear.
Besharat, S., Freedman, N.D., Katoonizadeh, A., Malekzadeh, R., Mohamadkhani, A., Moradi, A., Poustchi, H., Roshandel, G.   +7 more
core   +1 more source

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

Viruses, 2017
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and mortality. One peculiar observation in cells infected with HBV (or with closely‑related animal hepadnaviruses) is the presence of viral DNA integration in ...
T. Tu, M. Budzinska, N. Shackel, S. Urban   +3 more
semanticscholar   +1 more source

HBV‐RNA Co‐amplification May Influence HBV DNA Viral Load Determination

Hepatology Communications, 2020
Despite effective hepatitis B virus (HBV)‐DNA suppression, HBV RNA can circulate in patients receiving nucleoside/nucleotide analogues (NAs). Current assays quantify HBV DNA by either real‐time polymerase chain reaction (PCR), which uses DNA polymerase ...
Benjamin Maasoumy, Anna Maria Geretti, André Frontzek, Harrison Austin, Gudrun Aretzweiler, Monica Garcia‐Álvarez, Susanne Leuchter, Christian O. Simon, Ed G. Marins, Jesse A. Canchola, Markus Cornberg, Rafael Delgado, Heiner Wedemeyer   +12 more
doaj   +1 more source

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

Gut, 2020
Objective The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood.
V. Svicher, R. Salpini, L. Piermatteo, L. Carioti, A. Battisti, L. Colagrossi, R. Scutari, M. Surdo, V. Cacciafesta, A. Nuccitelli, N. Hansi, Francesca Ceccherini Silberstein, C. Perno, U. Gill, P. Kennedy   +14 more
semanticscholar   +1 more source

Potential mutations associated with occult hepatitis B virus status [PDF]

, 2014
Context: Occult hepatitis B virus (HBV) status (OHBS) is simply defined as the presence of HBV DNA in the liver (with or without detectable HBV DNA in the serum), in the absence of serum HBV surface antigen (HBsAg). Importance of OHBS is mostly clinical,
Besharat, S., Katoonizadeh, A., Moradi, A.   +2 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Serological and molecular characterization of HBV infection with HBsAg reactive and HBV DNA non-reactive

Zhongguo shuxue zazhi, 2022
Objective To investigate the serological and molecular characteristics of HBsAg+ /HBV DNA non-reactive (NR) infections. Methods Samples tested as HBsAg+ and HBV DNA NR were confirmed by individual NAT repeat testing, viral particle concentration by PEG ...
Chunxiang LI, Xiaohan GUO, Peng SUN, Xiaochun LIU, Dan LIU, Lei ZHOU, Liang ZANG, Daniel Candotti, Xuelian DENG   +8 more
doaj   +1 more source