Results 11 to 20 of about 1,553,849 (227)

HBV‐RNA Co‐amplification May Influence HBV DNA Viral Load Determination [PDF]

Hepatology Communications, 2020
Despite effective hepatitis B virus (HBV)‐DNA suppression, HBV RNA can circulate in patients receiving nucleoside/nucleotide analogues (NAs). Current assays quantify HBV DNA by either real‐time polymerase chain reaction (PCR), which uses DNA polymerase ...
Benjamin Maasoumy, Anna Maria Geretti, André Frontzek, Harrison Austin, Gudrun Aretzweiler, Monica Garcia‐Álvarez, Susanne Leuchter, Christian O. Simon, Ed G. Marins, Jesse A. Canchola, Markus Cornberg, Rafael Delgado, Heiner Wedemeyer   +12 more
doaj   +2 more sources

Serological and molecular characterization of HBV infection with HBsAg reactive and HBV DNA non-reactive

Zhongguo shuxue zazhi, 2022
Objective To investigate the serological and molecular characteristics of HBsAg+ /HBV DNA non-reactive (NR) infections. Methods Samples tested as HBsAg+ and HBV DNA NR were confirmed by individual NAT repeat testing, viral particle concentration by PEG ...
Chunxiang LI, Xiaohan GUO, Peng SUN, Xiaochun LIU, Dan LIU, Lei ZHOU, Liang ZANG, Daniel Candotti, Xuelian DENG   +8 more
doaj   +2 more sources

Hepatitis B virus infection in human immunodeficiency virus infected southern African adults: occult or overt--that is the question. [PDF]

PLoS ONE, 2012
Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) share transmission routes and are endemic in sub-Saharan Africa. The objective of the present study was to use the Taormina definition of occult HBV infection, together with stringent ...
Trevor G Bell, Euphodia Makondo, Neil A Martinson, Anna Kramvis   +3 more
doaj   +1 more source

Alinity m, a Random-Access System, for Hepatitis B Virus DNA Quantification in Plasma and Whole Blood Collected on Dried Blood Spots

mSphere, 2022
The International Liver Association recommends the use of accurate and sensitive molecular methods for determination of hepatitis B virus (HBV) DNA levels in plasma or serum of chronic HBsAg carriers. The level of HBV replication represents the strongest
Valérie Ortonne, Quentin Lucas, Olivia Garrigou, Alexandre Soulier, Dominique Challine, Jean-Michel Pawlotsky, Vincent Leroy, Stéphane Chevaliez   +7 more
doaj   +1 more source

Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV

BMC Infectious Diseases, 2022
Backgrounds: Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown.
Chih-Wei Tseng, Wen-Chun Liu, Chi-Yi Chen, Ting-Tsung Chang, Kuo-Chih Tseng   +4 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Persistently Elevated HBV Viral-Host Junction DNA in Urine as a Biomarker for Hepatocellular Carcinoma Minimum Residual Disease and Recurrence: A Pilot Study

Diagnostics, 2023
Hepatitis B virus (HBV)-host junction sequences (HBV-JSs) has been detected in the urine of patients with HBV infection. This study evaluated HBV-JSs as a marker of minimum residual disease (MRD) and tumor recurrence after treatment in HBV-hepatocellular
Selena Y. Lin, Dina Halegoua-DeMarzio, Peter Block, Yu-Lan Kao, Jesse Civan, Fwu-Shan Shieh, Wei Song, Hie-Won Hann, Ying-Hsiu Su   +8 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

3D landscape of Hepatitis B virus interactions with human chromatins

Cell Discovery, 2020
Hepatitis B viral (HBV) DNAs, including covalently closed circular DNA (cccDNA) and integrated HBV DNA forms, are considered to be primary contributors to the development and progression of HBV-associated liver diseases.
Bo Yang, Boyuan Li, Liyang Jia, Yongpeng Jiang, Xin Wang, Shaodong Jiang, Shunda Du, Xiong Ji, Pengyuan Yang   +8 more
doaj   +1 more source

Hepatocyte Endoplasmic Reticulum Stress Inhibits Hepatitis B Virus Secretion and Delays Intracellular Hepatitis B Virus Clearance After Entecavir Treatment

Frontiers in Medicine, 2021
Background: The aim of this study was to explore the effects of endoplasmic reticulum (ER) stress on hepatitis B virus (HBV) replication and the antiviral effect of entecavir (ETV).Methods: Thapsigargin (TG) and stearic acid (SA) were used to induce ER ...
Huan Chen, Maoyuan Mu, Qichuan Liu, Han Hu, Caiyun Tian, Guoyuan Zhang, Ying Li, Fangwan Yang, Shide Lin   +8 more
doaj   +1 more source