Results 101 to 110 of about 400,342 (335)

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Diagnostic value of serum STIP1 in HCC and AFP-negative HCC

Laboratory Medicine
Abstract Objective This study aimed to investigate the diagnostic value of stress-induced phosphoprotein 1 (STIP1) in serum for hepatocellular carcinoma (HCC) and alpha-fetoprotein (AFP)–negative HCC (ANHC).
Sun, Haiqing, Liu, Ning, Lou, Jinli
openaire   +2 more sources

A Promising Point‐of‐Care Testing Strategy: Ultrasmooth Gold Nanogroove Arrays Biosensor Combined with Initial Rate Analysis

Advanced Science, EarlyView.
This work reports a nanoplasmonic biosensing platform with exceptional surface sensitivity (0.618 nm nm−1, Δn = 0.117 nmol) and narrow linewidth (≈20 nm) under normal incidence. By integrating a miscellaneous‐protein strategy with initial rate analysis (IRA), this sensor can detect 1 ng mL−1 of AFP in serum with a broad linear range (1–104 ng mL−1 ...
Yi Liu, Shan Xing, Zhan Si, Kai He, Manchun Zheng, Yang Shen, Chongjun Jin   +6 more
wiley   +1 more source

Evolving epidemiology of HCC in Spain

JHEP Reports
The epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023.
Margarita Sala, Sonia Pascual, Maria Rosa Rota Roca, Ana María Matilla, Marta Campos, Manuel Delgado, María Teresa Ferrer, José Luís Montero, Jesús Manuel González-Santiago, Antonio Guerrero, Carles Aracil, Carlos Rodríguez-Lope, Marta Romero-Gutiérrez, Miguel Sogbe, Sergio Vázquez-Rodríguez, Javier Fuentes Olmo, Beatriz Mínguez, Luís Cortés-García, Nicolau Vallejo-Senra, Paloma Rendón Unceta, Ariadna Clos, Dácil Díaz-Bethencourt, Araceli García Sánchez, Raisa Quiñones Castro, Javier Bustamante, Christie Perelló, Juan José Urquijo Ponce, Hernán Andreu Serra, Camilo Julio Llamoza-Torres, Silvia Montoliu, Cristina Fernández-Marcos, Ana Guiberteau, Manuel Hernández-Guerra, Mercedes Vergara, Alexia María Fernández-López, María Paz Valer López-Fando, María Luisa Gutiérrez-García, Tánia Hernáez-Alsina, Susana Coll, Berta Cuyás, María Julia Morillas, Susana Rebolledo Olmedo, Miguel Fernández-Bermejo, Mercè Roget, Irina Calvo Ramos, Gemma Pacheco del Río, Raimon Rifà, Pilar Conde Gacho, Mónica Llorente Barrio, Mariano Gómez-Rubio, Irene Peñas, Isabel Serra, Alba Cachero, María Reig, Álvaro Giraldez, Marta Guerrero, José Xavier Segarra, José Luis Lledó, Álvaro Díaz-González, Carolina Delgado, Mercedes Iñarrairaegui, María Milagros Rodríguez-González, María Lázaro, María Bermúdez-Ramos, Alberto Lué, Esther Molina, Manuel Alberto Macías-Rodríguez, Manuel Rodríguez, Valentina Chiminazzo, María Varela   +69 more
openaire   +5 more sources

m6A‐Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), the m6A‐modified circRAPGEF1 destabilizes ASS1 mRNA via competitive binding to IGF2BP3, driving aspartate metabolic reprogramming in liver cancer stem cells (LCSCs). This cascade enhances stemness properties and reduces sorafenib sensitivity in LCSCs, thereby identifying circRAPGEF1 as a promising therapeutic target ...
Juanyi Shi, Sintim Mui, Yongcong Yan, Shaomin Liu, Kai Wen, Chuanchao He, Huoming Li, Hao Liao, Meng Tao, Jiahua Wen, Weidong Wang, Xiaoding Xu, Zhenyu Zhou, Zhiyu Xiao   +13 more
wiley   +1 more source

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC

Clinical Cancer Research, 2019
Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the ...
R. Pinyol, D. Sia, J. Llovet
semanticscholar   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression

Oncogene, 2019
Tumor-associated macrophages (TAMs) contribute to hepatocellular carcinoma (HCC) progression. However, the molecular mechanism underlying the infiltration of TAMs into HCC microenvironment is largely unclear.
D. Bao, J. Zhao, Xingchun Zhou, Qi Yang, Yibing Chen, Jianjun Zhu, P. Yuan, Jin Yang, T. Qin, S. Wan, J. Xing   +10 more
semanticscholar   +1 more source