Results 121 to 130 of about 236,151 (302)

CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway

Cancer Management and Research, 2020
Bashan Zhang, Fei Li, Zinian Zhu, Aijiao Ding, Jintong Luo Department of Clinical Laboratory, Affiliated Dongguan People’s Hospital, Southern Medical University of Dongguan, Dongguan City, Guangdong Province, People’s Republic of ...
Zhang B, Li F, Zhu Z, Ding A, Luo J
doaj  

ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization -5

, 2011
Howed that vessel area was significantly reduced in ENMD-1198-treated tumors (*P < 0.01). B) ENMD-1198 significantly decreased the number of proliferating (BrdUrd-positive) tumor cells in tissue sections (*P < 0.01).
Akira Mori (94991), Christian Moser (94989), Claus Hellerbrand (94992), Edward K Geissler (94994), Hans J Schlitt (94993), Oliver Stoeltzing (94996), William E Fogler (94995), Sven A Lang (94990)   +7 more
core   +1 more source

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

The Role of miR-1183: A Potential Suppressor in Hepatocellular Carcinoma via Regulating Splicing Factor SRSF1

Journal of Hepatocellular Carcinoma, 2023
Zhilu Yao,1,2,* Ning Liu,3,* Hui Lin,1 Yingqun Zhou2,4 1Department of Gastroenterology, Jingan District Zhabei Central Hospital, Shanghai, 200072, People’s Republic of China; 2Clinical Medical College of Shanghai Tenth People’s Hospital, Nanjing ...
Yao Z, Liu N, Lin H, Zhou Y
doaj  

Medical therapy of HCC [PDF]

Journal of Hepatology, 2022
Vogel, Arndt, Saborowski, Anna
openaire   +2 more sources

Therapeutic strategies in liver cancer cells

, 2019
In present work, we also provide an overview of the biology of HCC, molecular mechanism of the disease, risk factors of HCC. We give the review of the most recent and future possible therapies of early and advanced stage of HCC ...
Sepahizia, Sina
core  

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

AIM-index distinguishes HCC and non-HCC patients.

, 2014
(A) AIM-TB index vs. AIM-ALB index, AIM-PLT index or AIM-AST index in men with or without HCC. TB vs. ALB, PLT or AST are also presented. (B) AIM-ALB index vs. AIM-%PT index in women with or without HCC. ALB vs. %PT is also presented.
Sei Harada (642804), Mayumi Mori (642797), Toshiaki Gunji (547719), Jun Takahashi (464660), Ken-ichi Yamamura (14117), Masanori Abe (421879), Shinji Seto (642806), Kiyohiro Izumino (642802), Yukio Yoshida (642807), Toshihiro Kai (560571), Shin Ohnishi (642805), Tomoko Yamazaki (560572), Mihoko Ban (642798), Takeharu Asano (642801), Kazuhiko Koike (135022), Toru Miyazaki (560574), Kayo Aoyama (642803), Ryosuke Tateishi (135017), Yoichi Hiasa (156596), Maki Maeda (642800), Satoko Arai (560573), Akemi Nishijima (642799), Toru Takebayashi (462027), Ken-ichiro Inoue (65135)   +23 more
core   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source