Results 111 to 120 of about 236,151 (302)

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Baseline clinical characteristics between non-HCC group newly diagnosed HCC group and recurrence of HCC group.

, 2019
Baseline clinical characteristics between non-HCC group newly diagnosed HCC group and recurrence of HCC group.
Sheng-Shun Yang (3625481), Yen-Chun Peng (3873382), Hong-Zen Yeh (3625478), Chi-Sen Chang (3625472), Yi-Jie Huang (3873379)   +4 more
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Downregulated lncRNA SNHG18 Suppresses the Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma and Meditates the Antitumor Effect of Oleanolic Acid

Cancer Management and Research, 2022
Wenqi Song,1,* Xuemei Zhang,2,* Lin Feng,1 Yongwei Lai,1 Tongtong Li,1 Pengxia Zhang1 1 Key Laboratory of Microecology-immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, People’s ...
Song W, Zhang X, Feng L, Lai Y, Li T, Zhang P   +5 more
doaj  

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Roles of circRNAs in the Tumorigenesis and Metastasis of HCC: A Mini Review

Cancer Management and Research, 2022
Yichen Liu, Lei Wang, Wen Liu Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, 361102, People’s Republic of ChinaCorrespondence: Yichen Liu; Wen Liu, Email yc-liu ...
Liu Y, Wang L, Liu W
doaj  

2011 (IEEE) Symposium on Visual Languages and Human-Centric Computing, (VL/HCC) : Foreword

, 2011
Foreword di VL/HCC ...
Brad A. Myers, COSTAGLIOLA, Gennaro, Andrew Jensen Ko, Allen Cypher, Christopher Scaffidi, Jeffrey Nichols, Caitlin Kelleher   +6 more
core  

Expression of IL-23 in HCC and HCC cell lines.

, 2013
(A) Compare of IL-23 mRNA expression in 28 primary HCC with metastasis (M+) and 53 primary HCC without metastasis (M−) as well as their expression in tumor (T) and non-tumor (N) area ...
George Lau (305834), Xin-Yuan Guan (123632), Leilei Chen (214607), Yun-Fei Yuan (138642), John M. Luk (204918), Jian Li (41607), Jun Huang (127297), Dan Xie (41844)   +7 more
core   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome

, 2004
Objective: Hepatocellular carcinoma (HCC) is an increasing cause of mortality in HIV-seropositive individuals. The aim of the study was to compare the main features of HCC in HIV-seropositive individuals with those in to HIV-negative patients.
ASENSI V. AND VACCHER E. FOR THE HIV HCC COOPERATIVE ITALIANSPANISH GROUP, GELATTI, Umberto, PUOTI, Massimo, BRUNO R, SORIANO V, QUINTANE GP, GAETA GB, PRECONE D, DONATO, Francesco   +8 more
core   +1 more source