Results 131 to 140 of about 167,580 (260)

Evolving epidemiology of HCC in Spain

JHEP Reports
The epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023.
Margarita Sala, Sonia Pascual, Maria Rosa Rota Roca, Ana María Matilla, Marta Campos, Manuel Delgado, María Teresa Ferrer, José Luís Montero, Jesús Manuel González-Santiago, Antonio Guerrero, Carles Aracil, Carlos Rodríguez-Lope, Marta Romero-Gutiérrez, Miguel Sogbe, Sergio Vázquez-Rodríguez, Javier Fuentes Olmo, Beatriz Mínguez, Luís Cortés-García, Nicolau Vallejo-Senra, Paloma Rendón Unceta, Ariadna Clos, Dácil Díaz-Bethencourt, Araceli García Sánchez, Raisa Quiñones Castro, Javier Bustamante, Christie Perelló, Juan José Urquijo Ponce, Hernán Andreu Serra, Camilo Julio Llamoza-Torres, Silvia Montoliu, Cristina Fernández-Marcos, Ana Guiberteau, Manuel Hernández-Guerra, Mercedes Vergara, Alexia María Fernández-López, María Paz Valer López-Fando, María Luisa Gutiérrez-García, Tánia Hernáez-Alsina, Susana Coll, Berta Cuyás, María Julia Morillas, Susana Rebolledo Olmedo, Miguel Fernández-Bermejo, Mercè Roget, Irina Calvo Ramos, Gemma Pacheco del Río, Raimon Rifà, Pilar Conde Gacho, Mónica Llorente Barrio, Mariano Gómez-Rubio, Irene Peñas, Isabel Serra, Alba Cachero, María Reig, Álvaro Giraldez, Marta Guerrero, José Xavier Segarra, José Luis Lledó, Álvaro Díaz-González, Carolina Delgado, Mercedes Iñarrairaegui, María Milagros Rodríguez-González, María Lázaro, María Bermúdez-Ramos, Alberto Lué, Esther Molina, Manuel Alberto Macías-Rodríguez, Manuel Rodríguez, Valentina Chiminazzo, María Varela   +69 more
openaire   +9 more sources

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

The Prognostic Significance of CTSV Expression in Patients with Hepatocellular Carcinoma

International Journal of General Medicine
Yuping He,1,2,* Minghao Xu,2,3,* Chenhao Zhou,2,3 Qiongzhu Dong,2,4 Zhiqiu Hu,2,4,5 Ning Ren2– 4 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China; 2Key ...
He Y, Xu M, Zhou C, Dong Q, Hu Z, Ren N
doaj  

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The Role of the Aspire Alliance's Regional Collaboratives (RCs) in STEM Faculty Pathways

New Directions for Community Colleges, EarlyView.
ABSTRACT This article addresses a critical challenge in postsecondary education: the persistent lack of diversity and limited pathways into STEM faculty roles, particularly at community colleges. We examine how the Aspire Alliance's Regional Collaboratives (RCs) model works to create sustainable two‐year and four‐year partnerships to advance and ...
Lorenzo Baber, Karla Velasco, Jeongsan Hwang, Gianina Baker, Jess Gregg, Chandra Turpen, Craig Ogilvie   +6 more
wiley   +1 more source

First-Line Treatment for Advanced Hepatocellular Carcinoma: A Three-Armed Real-World Comparison

Journal of Hepatocellular Carcinoma
Robert Mahn,1,* Oscar André Glüer,1,* Farsaneh Sadeghlar,1 Christian Möhring,1 Taotao Zhou,1 Thomas Anhalt,1 Malte Benedikt Monin,1 Alexander Kania,2 Tim R Glowka,2 Georg Feldmann,3 Peter Brossart,3 Joerg C Kalff,2 Ingo GH Schmidt-Wolf,4 ...
Mahn R, Glüer OA, Sadeghlar F, Möhring C, Zhou T, Anhalt T, Monin MB, Kania A, Glowka TR, Feldmann G, Brossart P, Kalff JC, Schmidt-Wolf IGH, Strassburg CP, Gonzalez-Carmona MA   +14 more
doaj  

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

Chiral HPLC Separation of Phosphonothrixin and Phosphonate Derivatives and Electronic Circular Dichroism Characterization of the Isolated Enantiomers

ELECTROPHORESIS, EarlyView.
Natural compound phosphonothrixin's herbicidal activity resides exclusively in its (S)‐enantiomer, yet existing enantioselective syntheses are cumbersome, and direct chiral LC separation is hampered by the compound's high polarity, lack of aromatic groups, and metal chelation–induced peak tailing.
Mirna Maalouf, Maximilian Knab, Leon Gessner, Marc Engelhardt, Stella Friedrich, Harald Gross, Frank Boeckler, Chambers C. Hughes, Michael Lämmerhofer   +8 more
wiley   +1 more source

A Numerical Investigation of the Effects of Piston Bowl Geometry and Spray Angle on Combustion, Performance and Emission of a Diesel Engine

Energy Science &Engineering, EarlyView.
A piston bowl's design and spray angle improve air‐fuel mixing, resulting in more complete combustion and higher efficiency. Ansys Forte 2023 R1 a CFD software was used to analyze the effects of five combustion chamber geometries of cylinder, modified re‐entrant, re‐entrant, double‐stepped, and stepped on engine performance, combustion, and emission ...
Md. Nazmul Haque, Abdullah Al Rifat, Tafsirul Hassan, Md. Ifthaker Alam, Mohammad Mehedi Hasan Kazol, Md. Ashraful Islam, Abidur Rahman Adib, Mizanur Rahman   +7 more
wiley   +1 more source