Results 141 to 150 of about 63,442 (308)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

A Clinical audit: Prophylactic granulocyte transfusion to prevent severe febrile neutropenia and subsequent infections in paediatric high-risk patients with leukemia

Pediatric Hematology Oncology Journal
Aswathi Gangadharan, Suma TL, Smitha Shekar, Amit D. Galgali, Ashish Dhoot, Jyothi Goutham Kumar, Priyank Tripathi, Intezar Mehdi   +7 more
doaj   +1 more source

Kinderen met hyperthyreoïdie door verhoogd hCG

, 2014
We describe two children with hyperthyroidism secondary to elevated hCG levels: one patient with gestational trophoblastic disease and one patient with choriocarcinoma.
van Trotsenburg, A. S. Paul, Kamp, Gerdine A., Jöbsis, Jasper J., Merks, Johannes H. M.   +3 more
core  

In Vitro Sperm–Epididymosomes Interaction Immediately Before Fertilization Changes Sperm Fertility Potential

Andrology, EarlyView.
ABSTRACT Background Sperm acquire fertility ability during epididymal maturation mainly in the epididymal caput and corpus, and once matured, are stored in the epididymal cauda. During storage, interactions with cauda epididymosomes (epEVs) may influence sperm fertility potential; however, the role of such interactions on sperm fertility remains ...
Maíra Bianchi Rodrigues Alves, Maria Alice de Almeida, Ana Beatriz Bossois Moura, Laura Gabrielli Haupenthal, Raissa Braido Rangel, Flávio Vieira Meirelles, Juliano Coelho da Silveira, Felipe Perecin   +7 more
wiley   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Genomic profiling of pediatric hemato-lymphoid malignancies and inherited bone marrow failure syndrome using next-generation sequencing (NGS): An institutional study

Pediatric Hematology Oncology Journal
Amit D. Galgali, Intezar Mehdi, T.L. Suma, Smitha Shekar   +3 more
doaj   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

A Comparative Evaluation Of Sensitivity And Specificity Of Qualitative Urine Pregnancy Tests With Rapid hCG Immunoenzymatic Test

پیاورد سلامت, 2014
Background and Aim: Early diagnosis of pregnancy is very important to prevent fetal damage due to specific drug consumption and high-risk behaviors. The objective of this study was to compare the sensitivity and specificity of quantitative agglutination ...
Arezoo Rasti, Mehrnaz Geranmayeh, Hamid Reza Shah Mohammadi, Reza Golam Nejad Jafari, Fatemeh Niazi, Samaneh Shabani, Roya Sharifian, Yousef Erfani   +7 more
doaj  

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Impact of Surgical Approach on Survival and Recurrence in Borderline and Malignant Phyllodes Tumours: A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Phyllodes tumours of the breast exhibit a spectrum of biologic behaviour, with a predisposition to recur locally and metastasize distantly in their malignant form. There are limited data regarding the optimal surgical approach. Objectives Our systematic review and meta‐analysis aimed to determine the impact of breast conserving ...
Christopher G. Harris, Gillian Heller, Farhad Azimi, Belinda Chan, Susannah Graham, Cindy Mak, Sanjay Warrier   +6 more
wiley   +1 more source