Results 41 to 50 of about 69,711 (285)

Association between tumour stroma ratio and other histopathological markers and lymph node metastasis in patients with oral cavity cancer

The Egyptian Journal of Otolaryngology
Background Tumour stroma ratio (TSR) has recently been introduced as a promising prognostic parameter in oral cavity cancers. However, the correlation between TSR and histopathological markers in oral cavity squamous cell carcinoma (OCSCC) patients was ...
Prakash Pandit, Vijay Palwe, Sai Krishna U., Sucheta Gandhe, Yogesh Pawar, Yasam Venkata Ramesh, Raj Nagarkar   +6 more
doaj   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Development of Label-Free Impedimetric Hcg-Immunosensor Using Screen-Printed Electrode [PDF]

, 2011
Screen-printing (thick-film) technology is well identified as a reliable technique for fabrication of electrodes which can be used as transducer in biosensor, with several advantages including low cost, design flexibility, process automation, good ...
Nguyen, Xuan Viet, Takamura, Yuzuru, Truong, TN Lien, Ukita, Yoshiaki, Chikae, Miyuki   +4 more
core   +1 more source

Transport–Reaction–Signal Coupling in Lateral Flow Assays for Next‐Generation Point‐of‐Care Diagnostics

Advanced Science, EarlyView.
Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan, Yuewei Li, Chao Mi, Zhengwen Yang, Lana McClements, Steven J. Langford, Jiayan Liao   +6 more
wiley   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

A Rare Case of Amelanotic Mucosal Malignant Melanoma of the Penis: First of Its Kind Case Report from India

Libyan International Medical University Journal
Amelanotic mucosal malignant melanoma of the penis is extremely rare. To our knowledge, this is the first case from India. In the present case report, we have discussed the diagnostic challenges, treatment, and prognosis related with this rare condition.
Soundarya Varadarajan, Vikas Jain, Raj Nagarkar, Sucheta Gandhe, Yasam Venkata Ramesh   +4 more
doaj   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

hCG concentration from individual samples of EP-hCG and LP-hCG.

, 2020
hCG concentration from individual samples of EP-hCG and LP-hCG.
Shabnam Bobdiwala (8436768), Maria Panico (245670), Stuart M. Haslam (208187), Anne Dell (79797), Linda Ibeto (8436765), Gary Clark (8436777), Mark R. Johnson (117795), Maya Al-Memar (8436771), Aristotelis Antonopoulos (1856338), Paola Grassi (191372), Julian Norman Taylor (8436774), Tom Bourne (175288), Michael Seckl (7055864), Poh-Choo Pang (5663056), Mark Davis (144230), Paul Davis (5775), Paula Almeida (5449031), Richard Harvey (619603)   +17 more
core   +1 more source

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source