Results 131 to 140 of about 46,134 (291)
The changing immune landscape of innate‐like T cells and other innate cells throughout life
Immunology &Cell Biology, Volume 104, Issue 1, Page 74-88, January 2026.The phenotype of innate‐like T cells changes with age. Here we describe these changes in relation to other subsets of innate cells. Abstract Spectral flow cytometry is an advanced immunological tool that can enable comprehensive analysis of the immune system by simultaneously comparing innate and adaptive immune cells.
Marziyeh Taheri +9 more
wiley +1 more source
The Journal of Clinical Investigation, 2022 Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide.
Eleanor C. Semmes +12 more
doaj +1 more source
Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug
HLA, Volume 107, Issue 1, January 2026.ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk +8 more
wiley +1 more source
Understanding HCMV Latency Using Unbiased Proteomic Analyses
Pathogens, 2020 Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic (productive) infection depending upon cell type, cytokine milieu and the differentiation status of the infected cell. Undifferentiated cells, such as precursor cells of the myeloid lineage, support a latent infection whereas terminally differentiated cells, such as ...
Poole, Emma, Sinclair, John
openaire +3 more sources
Cellular Physiology and Biochemistry, 2016 Background/Aims: Rho GTPases are crucial regulators of the actin cytoskeleton, membrane trafficking and cell signaling and their importance in cell migration and invasion is well- established.
Melpomeni Tseliou +5 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 13, Issue 12, December 2025.Molecular docking and molecular dynamics simulations revealed that quercetin binds tightly to the core targets (THBS1, SERPINE1, and IGF1R) of nicotine‐related oral carcinoma, suggesting its potential as a therapeutic agent for oral cancer. In vitro experiments demonstrated that quercetin can inhibit the expression of the core targets (THBS1, SERPINE1,
Xiaopeng Guo +7 more
wiley +1 more source
Vaccines, 2020 Human cytomegalovirus (HCMV) core fusion machinery proteins gB and gH/gL, and accessory proteins UL128/UL130/UL131A, are the key envelope proteins that mediate HCMV entry into and infection of host cells. To determine whether these HCMV envelope proteins
Xinle Cui +5 more
doaj +1 more source
HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs
Frontiers in Cellular and Infection Microbiology, 2016 Objective: The study was designed to evaluate the role of Human cytomegalovirus (HCMV) infection on homebox (HOX) gene expression and the effects of overexpression of HOX genes on proliferation and apoptosis of vascular smooth muscle cells (VSMCs ...
Lingfang Li +9 more
semanticscholar +1 more source
mBio, 2016 Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids.
S. Karniely +10 more
doaj +1 more source
Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]
, 2003 The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Chalupny, NJ +6 more
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