Results 131 to 140 of about 44,631 (298)

Adult brain cancer incidence patterns: A comparative study between Japan and Japanese Americans

International Journal of Cancer, Volume 157, Issue 3, Page 436-444, 1 August 2025.
What's new? The risk factors for brain tumors remain largely unknown. Building on the legacy of migration studies, this study compared the incidence of adult malignant brain and central nervous system tumors in Japan and among Japanese Americans and other ethnic populations in the United States.
Byron Sigel, Diana R. Withrow, Lene H. S. Veiga, Eiko Saito, Tomohiro Matsuda, Kota Katanoda   +5 more
wiley   +1 more source

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

mBio, 2016
Infection with human cytomegalovirus (HCMV) profoundly affects cellular metabolism. Like in tumor cells, HCMV infection increases glycolysis, and glucose carbon is shifted from the mitochondrial tricarboxylic acid cycle to the biosynthesis of fatty acids.
S. Karniely, M. P. Weekes, R. Antrobus, J. Rorbach, L. van Haute, Y. Umrania, D. L. Smith, R. J. Stanton, M. Minczuk, P. J. Lehner, J. H. Sinclair   +10 more
doaj   +1 more source

Antineoplastic Effects of Thymoquinone on Pancreatic Atypical Acinar Cell Foci Treated With Azaserine

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 8, August 2025.
The main purpose of this study was to investigate the antioxidant and anticarcinogenic effects of TQ, which has many traditional uses and is naturally found in Nigella sativa seeds, on the neoplastic changes induced by azaserine in exocrine pancreatic acinar cells.
Hasan Yildiz, Başak Hartavi
wiley   +1 more source

Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals*

Molecular & Cellular Proteomics, 2017
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and ...
Kyle C. Arend, Erik M. Lenarcic, Heather A. Vincent, N. Rashid, E. Lazear, Ian M. McDonald, T. S. Gilbert, Michael P. East, Laura E. Herring, G. Johnson, L. Graves, Nathaniel J. Moorman   +11 more
semanticscholar   +1 more source

Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation

Frontiers in Immunology
Human cytomegalovirus (HCMV) is the most common virus to affect the recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). HCMV reactivation increases the risk of secondary fungal and bacterial infections, as well as that of non ...
Yuanqi Zhao, Yuanqi Zhao, Yuanqi Zhao, Sisi Zhen, Sisi Zhen, Jiali Wang, Jiali Wang, Jieru Wang, Jieru Wang, Runzhi Ma, Runzhi Ma, Li Liu, Li Liu, Aiming Pang, Aiming Pang, Rongli Zhang, Rongli Zhang, Xin Chen, Xin Chen, Weihua Zhai, Weihua Zhai, Donglin Yang, Donglin Yang, Yi He, Yi He, Mingzhe Han, Mingzhe Han, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng   +30 more
doaj   +1 more source

Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody

Nature Communications, 2015
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its ...
S. Chandramouli, C. Ciferri, P. Nikitin, Stefano Caló, Rachel Gerrein, Kara Balabanis, J. Monroe, C. Hebner, A. Lilja, E. Settembre, A. Carfi   +10 more
semanticscholar   +1 more source

Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins

Protein Science, Volume 34, Issue 8, August 2025.
Abstract The ester bond crosslink discovered within bacterial adhesin proteins offers a captivating insight into the convergent evolution of enzyme‐like machinery. Crystal structures reveal a putative catalytic triad comprising an acid–base–nucleophile combination and an oxyanion‐like site that suggests a serine protease‐like mechanism drives the ...
Yuliana Yosaatmadja, Vanessa Ung, Xinlu Liu, Yixuan Zhao, Julia K. Wardega, Aria Shetty, Sophie Schoensee, Ivanhoe K. H. Leung, Jeremy R. Keown, David C. Goldstone, Edward N. Baker, Paul G. Young, Davide Mercadante, Christopher J. Squire   +13 more
wiley   +1 more source

Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection

The Journal of Clinical Investigation, 2022
Human cytomegalovirus (HCMV) is the most common congenital infection and a leading cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide.
Eleanor C. Semmes, Itzayana G. Miller, Courtney E. Wimberly, Caroline T. Phan, Jennifer A. Jenks, Melissa J. Harnois, Stella J. Berendam, Helen Webster, Jillian H. Hurst, Joanne Kurtzberg, Genevieve G. Fouda, Kyle M. Walsh, Sallie R. Permar   +12 more
doaj   +1 more source

Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL [PDF]

, 2005
Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity.
Dunn, C, Hegde, NR, Jarvis, MA, Johnson, DC, Lewinsohn, DM, Nelson, JA   +5 more
core  

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

PLoS Pathogens, 2015
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I
J. Hsu, D. J. van den Boomen, P. Tomasec, M. Weekes, R. Antrobus, R. Stanton, E. Růčková, D. Sugrue, G. Wilkie, A. Davison, G. Wilkinson, P. Lehner   +11 more
semanticscholar   +1 more source