Results 141 to 150 of about 17,820 (185)

Adoptive immunotherapy of HCMV infection

Cytotherapy, 2007
Human cytomegalovirus (HCMV) infection or reactivation is a frequent cause of morbidity and mortality in immunocompromised individuals such as transplant recipients. Primary HCMV infection or reactivation of HCMV from latency is mostly asymptomatic in immunocompetent individuals and is controlled by the host's cell-mediated immune response.
M, Kapp, S M, Tan, H, Einsele, Gu, Grigoleit   +3 more
openaire   +2 more sources

Models of HCMV latency and reactivation

Trends in Microbiology, 2003
Human cytomegalovirus (HCMV) is a ubiquitous β-herpesvirus that causes severe disease primarily in immunosuppressed individuals. A major characteristic of HCMV, with obvious clinical importance, is its ability to establish lifelong infection within the host following the initial acute infection.
Daniel N, Streblow, Jay A, Nelson
openaire   +2 more sources

Methods in Anti-HCMV Research

2003
The study of strategies for the treatment of human cytomegalovirus (HCMV) infection starts with the discovery of compounds that are potent and selective inhibitors of HCMV replication. Selectivity means that the window between the concentrations that block viral replication on the one hand and those that affect host cell functions on the other is ...
J, Neyts, G, Andrei, R, Snoeck, A, Meerbach, E, De Clercq   +4 more
openaire   +2 more sources

Specificity for HCMV strains

Nature Reviews Immunology, 2018
Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.
openaire   +2 more sources

Role of human cytomegalovirus (HCMV)-specific antibody in HCMV-infected pregnant women

Early Human Development, 2014
Maternal preconception immunity confers substantial protection against HCMV infection and disease to the unborn child. However, the protective role played by single components of virus-specific humoral and cellular immunity is poorly defined. Recently, it was discovered that UL128-131 gene products are essential for the virus to exert endothelial ...
Maria Grazia, Revello, Chiara, Fornara, Alessia, Arossa, Paola, Zelini, Daniele, Lilleri   +4 more
openaire   +2 more sources

Human cytomegalovirus (HCMV) genotype populations in immunocompetent individuals during primary HCMV infection

Journal of Clinical Virology, 2010
Immunocompetent individuals can harbor multiple human cytomegalovirus (HCMV) genotypes. However, little is known about the genotype populations acquired during primary HCMV infection.The aim of this study was to assess the HCMV genotype populations present in the blood of non-immunocompromised patients experiencing primary HCMV infection.HCMV ...
Irene, Görzer, Heidrun, Kerschner, Monika, Redlberger-Fritz, Elisabeth, Puchhammer-Stöckl   +3 more
openaire   +2 more sources

Diagnosis and prognostic markers of HCMV infection

Journal of Clinical Virology, 2001
Human cytomegalovirus (HCMV) infections are frequently observed as well in immunocompetent as in immunocompromised patients. Diagnostic techniques for HCMV detection have greatly improved during the recent years. Detection of HCMV by culture has been bettered by centrifugating samples in a shell vial and by using monoclonal antibody to the immediate ...
L, Grangeot-Keros, D, Cointe
openaire   +2 more sources

Challenges and advances in the management of HCMV infections

Virologie
Human cytomegalovirus (HCMV) is one of the most important causes of complications in immunocompromised patients and congenital infections. HCMV could also represent an interesting target for treatment to limit the progression of glioblastoma, a highly aggressive tumor. Ganciclovir, foscarnet and cidofovir, which interfere with the activity of the viral
Gourin, Claire, Flores, Thelma, Mafi, Sarah, Malnou, Cécile, Alain, Sophie, Hantz, Sébastien, Ligat, Gaetan   +6 more
openaire   +2 more sources

Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry

Cell, 2021
Christopher P Arthur, Claudio Ciferri, Matthew C Johnson   +2 more
exaly  

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

Immunity, 2023
Florian Klein, Dagmar Stöhr, Hanna Janicki   +2 more
exaly