Results 1 to 10 of about 5,274 (162)

Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells [PDF]

Vaccines, 2020
Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, their implication with regard
Frank Klawonn, Carlos A Guzman, Rebecca J Cox   +2 more
exaly   +4 more sources

Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27 [PDF]

Arthritis Research & Therapy
Background This study aims to explore the common mechanisms between aging and the pathogenesis of ankylosing spondylitis (AS) and to identify potential therapeutic targets.
Kunhai Tang, Xiaobei Ma, Jian Gao, Lilu Zu, Yanyun Ma, Dachun Zhuo, Chenyuan Wu, Yulong Tang, Feng Qian, Li Jin, Jiucun Wang, Qi Zhu, Jing Liu   +12 more
doaj   +3 more sources

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Sofya Kust, Elena Kovalenko, Ivan V Zvyagin   +2 more
exaly   +3 more sources

High-Dimensional Immune Profiling Identifies Circulating NKT-Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset. [PDF]

Immunology
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
González de Castro C, Ruiz Rebollo ML, Cal-Sabater P, Arribas-Rodríguez E, Martín-Muñoz Á, Gonzalez Del Hierro A, Perez Mazzali M, Matesanz-Isabel J, Gonzalo-Benito H, Cuesta-Sancho S, Bernardo D.   +10 more
europepmc   +2 more sources

High IL-10 levels during CRS are negatively associated with NK-cell recovery after CAR-T cell therapy. [PDF]

Clin Transl Immunology
This study demonstrates that high IL‐10 levels during cytokine release syndrome significantly delay natural killer (NK)‐cell recovery after CD19 CAR‐T cell therapy, increasing viral infection risks. Mechanistically, IL‐10 impairs NK‐cell recovery by promoting apoptosis and ferroptosis, suggesting that targeting IL‐10 or employing anti‐inflammatory ...
Wang X, Luo W, Li Y, Wu J, Tang L, Li C, Liu Q, Chen Z, Hu Y, Mei H.   +9 more
europepmc   +2 more sources

The Potential Role of Expression of HLA-E and HLA-G in Organ Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation offers a promising solution to the shortage of human organs for transplantation but requires overcoming numerous immune responses—particularly those mediated by the innate immune system through natural killer (NK) cells and macrophages.
Sumbo JK, Hu X, Wolf E, Cooper DKC, Buhler LH.   +4 more
europepmc   +2 more sources

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases. [PDF]

MedComm (2020)
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Deng K, Chong WP.
europepmc   +2 more sources

Parallel processing of T cells and natural killer cells to enhance <i>in vivo</i>CAR T cell activity against blood and solid cancers. [PDF]

Clin Transl Immunology
Abstract Objectives Despite their anti‐cancer properties, natural killer (NK) cells are discarded during CAR T cell manufacturing. NK cells display promising responses as a cell therapy, exhibiting remarkable safety at high doses. Moreover, NK cells have complementary cytokine profiles and distinct antigen‐recognition pathways to supplement CAR T cell ...
Dobson LJ, Marron PW, Drabble AH, Liyanage TD, Pe KC, Slaney CY, Hock BD, McLellan AD.   +7 more
europepmc   +2 more sources

Reduced spike specific T-cell responses in COVID-19 vaccinated subjects undergoing SARS-CoV-2 breakthrough infection [PDF]

Frontiers in Immunology
IntroductionT-cell responses to SARS-CoV-2 remain largely preserved across variants despite waning neutralizing antibodies. However, T-cell immunity may vary with the host’s immune status, and data on T-cell responses in post-vaccine infections (PVI) are
Stefania Varchetta, Federica Sole Golfetto, Patrizia Bono, Annapaola Callegaro, Tanya Fabbris, Andrea Favalli, Mariacristina Crosti, Tullia Maria De Feo, Nathalie Iannotti, Giorgio Bozzi, Valeria Castelli, Bianca Mariani, Antonio Muscatello, Sergio Abrignani, Sergio Abrignani, Renata Grifantini, Alessandra Bandera, Alessandra Bandera, Andrea Lombardi, Andrea Lombardi   +19 more
doaj   +2 more sources

Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques

Frontiers in Immunology, 2022
Previous research on adaptive NK cells in rhesus macaques suffered from the lack of specific antibodies to differentiate between inhibitory CD94/NKG2A and stimulatory CD94/NKG2C heterodimeric receptors. Recently we reported an expansion of NKG2C receptor-
Mohammad Zahidul Hasan, Mohammad Zahidul Hasan, Charlotte Höltermann, Charlotte Höltermann, Beatrix Petersen, Annette Schrod, Kerstin Mätz-Rensing, Artur Kaul, Gabriela Salinas, Ralf Dressel, Lutz Walter   +10 more
doaj   +1 more source