Results 1 to 10 of about 4,211 (109)

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Frontiers in Immunology, 2021
T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56+ and CD56− subsets most of the NKG2C+ T cells had a phenotype of
Sofya Kust, Elena Kovalenko, Ivan Zvyagin   +2 more
exaly   +3 more sources

Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C

Frontiers in Immunology, 2019
Human memory-like NK cells are commonly defined by either a lack of FcεRIγ or gain of NKG2C expression. Here, we investigated the heterogeneity of human CD56dim NK cell subpopulations according to the expression of FcεRIγ and NKG2C in a large cohort (n =
Sungha Park, Su-Hyung Park, Sungjin Kim   +2 more
exaly   +3 more sources

Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation

Frontiers in Immunology, 2018
Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV.
Rohtesh S Mehta, Amanda Olson, Richard Champlin   +2 more
exaly   +3 more sources

NKG2C+NKG2A− Natural Killer Cells are Associated with a Lower Viral Set Point and may Predict Disease Progression in Individuals with Primary HIV Infection

Frontiers in Immunology, 2017
Natural killer (NK) cells are the first line of defense against pathogens of the immune system and also play an important role in resistance against HIV. The activating receptor NKG2C and the inhibitory receptor NKG2A co-modulate the function of NK cells
Hong Shang, Yongjun Jiang, Yajing Fu
exaly   +3 more sources

Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells

Vaccines, 2020
Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, their implication with regard
Frank Klawonn, CARLOS Alberto Guzman, Rebecca Jane Cox   +2 more
exaly   +3 more sources

Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27 [PDF]

Arthritis Research & Therapy
Background This study aims to explore the common mechanisms between aging and the pathogenesis of ankylosing spondylitis (AS) and to identify potential therapeutic targets.
Kunhai Tang, Xiaobei Ma, Jian Gao, Lilu Zu, Yanyun Ma, Dachun Zhuo, Chenyuan Wu, Yulong Tang, Feng Qian, Li Jin, Jiucun Wang, Qi Zhu, Jing Liu   +12 more
doaj   +2 more sources

Reduced spike specific T-cell responses in COVID-19 vaccinated subjects undergoing SARS-CoV-2 breakthrough infection [PDF]

Frontiers in Immunology
IntroductionT-cell responses to SARS-CoV-2 remain largely preserved across variants despite waning neutralizing antibodies. However, T-cell immunity may vary with the host’s immune status, and data on T-cell responses in post-vaccine infections (PVI) are
Stefania Varchetta, Federica Sole Golfetto, Patrizia Bono, Annapaola Callegaro, Tanya Fabbris, Andrea Favalli, Mariacristina Crosti, Tullia Maria De Feo, Nathalie Iannotti, Giorgio Bozzi, Valeria Castelli, Bianca Mariani, Antonio Muscatello, Sergio Abrignani, Sergio Abrignani, Renata Grifantini, Alessandra Bandera, Alessandra Bandera, Andrea Lombardi, Andrea Lombardi   +19 more
doaj   +2 more sources

Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1 [PDF]

EMBO Molecular Medicine
Natural Killer (NK) cells are promising candidates for targeting persistently infected CD4 + T cells in people with HIV-1 (PWH). However, chronicity of HIV-1 infection impairs NK cell functionality, requiring additional strategies to potentiate their ...
Ildefonso Sánchez-Cerrillo, María Agudo-Lera, Olga Popova, Ilya Tsukalov, Marta Calvet-Mirabent, Ignacio de los Santos, Lucio García-Fraile, Patricia Fuentes, Cristina Delgado-Arévalo, Juan Alcain, Nerea Sánchez-Gaona, Judith Grau-Expósito, María Lázaro-Díez, Cecilia Muñoz-Calleja, Arantzazu Alfranca, Meritxell Genescà, Julia G Prado, Vladimir Vrbanac, Alejandro Balazs, María José Buzón, María L Toribio, María A Muñoz-Fernández, Francisco Sánchez-Madrid, Enrique Martín-Gayo   +23 more
doaj   +2 more sources

Single-cell analysis unravels the role of NK cells and monocytes in the control of SARS-CoV-2 breakthrough infections in vaccinated individuals [PDF]

Human Vaccines & Immunotherapeutics
Analyzing the antiviral response of natural killer (NK) cells and monocytes is essential to understanding vaccine protection in an immunized population facing SARS-CoV-2 variant breakthrough infections (BTIs).
Huiwen Zheng, Jing Li, Xin Zhang, Yun Liao, Heng Li, Xin Zhao, Zihan Zhang, Jingjing Wang, Li Yu, Dandan Li, Heng Zhao, Haijing Shi, Longding Liu   +12 more
doaj   +2 more sources

Polycytotoxic T cells mediate antimicrobial activity against intracellular Mycobacterium tuberculosis [PDF]

Infection and Immunity
Protection against infections with intracellular bacteria requires the interaction of macrophages and T-lymphocytes, including CD8+ T cells. Recently, the expression of natural killer cell receptors NKG2A and NKG2C was introduced as markers of CD8+ T ...
Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger   +7 more
doaj   +2 more sources