Results 11 to 20 of about 4,280 (166)
Dissection of the NKG2C NK cell response against Puumala Orthohantavirus.
PLoS Neglected Tropical Diseases, 2021 BackgroundInfections with the Puumala orthohantavirus (PUUV) in humans may cause hemorrhagic fever with renal syndrome (HFRS), known as nephropathia epidemica (NE), which is associated with acute renal failure in severe cases.
Hannes Vietzen +3 more
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Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients [PDF]
Frontiers in Immunology, 2015 Adaptive natural killer (NK) cell responses to human cytomegalovirus (CMV) infection are characterized by the expansion of NKG2C+ NK cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs). Here, we set out to study the
vivien eBeziat +11 more
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Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation [PDF]
JCI Insight, 2022 CMV infection remains an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several investigators have reported that adaptive NKG2C+ NK cells persistently expand during CMV reactivation.
Xing-Xing Yu +16 more
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Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex. [PDF]
PLoS ONE, 2014 The DAP12-NKG2C activating immunoreceptor complex is one of the multisubunit transmembrane protein complexes in which ligand-binding receptor chains assemble with dimeric signal-transducing modules through non-covalent associations in their transmembrane
Peng Wei +6 more
doaj +4 more sources
Activating KIRs and NKG2C in viral infections: towards NK cell memory? [PDF]
Frontiers in Immunology, 2015 Natural Killer cells are important players in the immune defence against viral infections. The contribution of activating Killer Immunoglobulin-like Receptors (KIRs) and CD94/NKG2C in regulating anti-viral responses has recently emerged.
Mariella eDella Chiesa +4 more
doaj +4 more sources
Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients [PDF]
Respiratory Research, 2020 Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations.
Sergi Pascual-Guardia +7 more
doaj +4 more sources
Frontiers in Immunology, 2022 Previous research on adaptive NK cells in rhesus macaques suffered from the lack of specific antibodies to differentiate between inhibitory CD94/NKG2A and stimulatory CD94/NKG2C heterodimeric receptors. Recently we reported an expansion of NKG2C receptor-
Mohammad Zahidul Hasan +10 more
doaj +1 more source
NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme
International Journal of Molecular Sciences, 2022 In glioblastoma, non-classical human leucocyte antigen E (HLA-E) and HLA-G are frequently overexpressed. HLA-E loaded with peptides derived from HLA class I and from HLA-G contributes to inhibition of natural killer (NK) cells with expression of the inhibitory receptor CD94/NKG2A.
Shafiq Murad +7 more
openaire +2 more sources
Frontiers in Immunology, 2022 NKG2C+ natural killer (NK) cell plays a vital role in CMV infection control after hematopoietic stem cell transplantation (HSCT). However, the modulation on NKG2C+ NK cell reconstitution is still unclear. NK cell education is affected by the interactions
Wei Zuo +10 more
doaj +1 more source
NKG2C Deletion Is a Risk Factor of HIV Infection [PDF]
AIDS Research and Human Retroviruses, 2012 NK cell function is important in the immune response to HIV infection. NKG2C and NKG2A are activating and inhibitory NK cell receptors, respectively, and their only known ligand, HLA-E, demonstrates increased expression in HIV infection and presents at least one HIV-derived peptide.
Rachel, Thomas +5 more
openaire +2 more sources