Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients
Frontiers in Immunology, 2015 Adaptive natural killer (NK) cell responses to human cytomegalovirus (CMV) infection are characterized by the expansion of NKG2C+ NK cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs). Here, we set out to study the
vivien eBeziat +11 more
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Molecular dynamic simulation of the self-assembly of DAP12-NKG2C activating immunoreceptor complex. [PDF]
PLoS ONE, 2014 The DAP12-NKG2C activating immunoreceptor complex is one of the multisubunit transmembrane protein complexes in which ligand-binding receptor chains assemble with dimeric signal-transducing modules through non-covalent associations in their transmembrane
Peng Wei +6 more
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Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C [PDF]
Frontiers in Immunology, 2019 Human memory-like NK cells are commonly defined by either a lack of FcεRIγ or gain of NKG2C expression. Here, we investigated the heterogeneity of human CD56dim NK cell subpopulations according to the expression of FcεRIγ and NKG2C in a large cohort (n =
Kyung Hwan Kim +7 more
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Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation [PDF]
Frontiers in Immunology, 2018 Cytomegalovirus (CMV) remains a major cause of morbidity following allogeneic hematopoietic stem cell transplant. Natural killer cells expressing NKG2C have been shown to play a role in the immune surveillance of human CMV.
Kai Cao +19 more
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Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans [PDF]
Cell Reports, 2016 Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C ...
Lisa L. Liu +17 more
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Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.
PLoS Pathogens, 2018 Natural killer (NK) cells classically typify the nonspecific effector arm of the innate immune system, but have recently been shown to possess memory-like properties against multiple viral infections, most notably CMV.
Daniel R Ram +6 more
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Respiratory Research, 2020 Chronic obstructive pulmonary disease (COPD) is a chronic and often progressive disorder with a heterogeneous presentation and frequent systemic manifestations.
Sergi Pascual-Guardia +7 more
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NKG2C+NKG2A− Natural Killer Cells are Associated with a Lower Viral Set Point and may Predict Disease Progression in Individuals with Primary HIV Infection [PDF]
Frontiers in Immunology, 2017 Natural killer (NK) cells are the first line of defense against pathogens of the immune system and also play an important role in resistance against HIV. The activating receptor NKG2C and the inhibitory receptor NKG2A co-modulate the function of NK cells
Meichen Ma +31 more
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Increased proliferative response of highly differentiated CD57+NKG2C+NK cells expressing NKG2A
Медицинская иммунологияDuring infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva +2 more
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Dissection of the NKG2C NK cell response against Puumala Orthohantavirus.
PLoS Neglected Tropical Diseases, 2021 BackgroundInfections with the Puumala orthohantavirus (PUUV) in humans may cause hemorrhagic fever with renal syndrome (HFRS), known as nephropathia epidemica (NE), which is associated with acute renal failure in severe cases.
Hannes Vietzen +3 more
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