Results 21 to 30 of about 4,280 (166)

Complete genomic characterization of a new KLRC2 allele, NKG2C*03 [PDF]

HLA, 2021
The novel NKG2C*03 allele encodes a hybrid of the NKG2C*01 and NKG2C*02 primary structures.
Judit Asenjo, Aura Muntasell, Miguel López‐Botet, Manuela Moraru, Carlos Vilches   +4 more
openaire   +4 more sources

CXCR6+ and NKG2C+ Natural Killer Cells Are Distinct With Unique Phenotypic and Functional Attributes Following Bone Marrow Transplantation

Frontiers in Immunology, 2022
Reactivation of human cytomegalovirus (HCMV) is a life-threatening complication in transplant patients. Natural Killer (NK) cells are the first lymphocyte lineage to reconstitute following an allogeneic hematopoietic stem cell transplant (HSCT).
Kevin Aviles-Padilla, Laura S. Angelo, Dwight Fan, Dwight Fan, Silke Paust, Silke Paust, Silke Paust   +6 more
doaj   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients - PART 1: Risk Factors, Clinical Impact and Immune Response. [PDF]

Rev Med Virol
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Kaplan D, Blyth E, Sutrave G, Yong MK, Gottlieb DJ, Abendroth A, Slobedman B, Stern L.   +7 more
europepmc   +2 more sources

NKG2C zygosity influences CD94/NKG2C receptor function and the NK‐cell compartment redistribution in response to human cytomegalovirus [PDF]

European Journal of Immunology, 2013
Human cytomegalovirus (HCMV) infection promotes a persistent expansion of a functionally competent NK‐cell subset expressing the activating CD94/NKG2C receptor. Factors underlying the wide variability of this effect observed in HCMV‐seropositive healthy individuals and exacerbated in immunocompromized patients are uncertain.
Aura, Muntasell, María, López-Montañés, Andrea, Vera, Gemma, Heredia, Neus, Romo, Judith, Peñafiel, Manuela, Moraru, Joan, Vila, Carlos, Vilches, Miguel, López-Botet   +9 more
openaire   +2 more sources

Human Adaptive Natural Killer Cells: Beyond NKG2C [PDF]

Trends in Immunology, 2016
Paradigm-shifting studies have identified NKG2C(+) adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C(-/-) HCMV(+) individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/
Julia A, Wagner, Todd A, Fehniger
openaire   +2 more sources

Coordination of NK cell markers expression and IgG response in hCMV infection

Медицинская иммунология, 2023
Human cytomegalovirus (hCMV) is a prevalent virus that affects a large proportion of the population worldwide. Natural Killer (NK) cells are essential immune cells that play a crucial role in controlling hCMV infection.
M. O. Ustiuzhanina, Ju. D. Vavilova, N. A. Alekseeva, G. V. Lutcenko, D. M. Chudakov, E. I. Kovalenko   +5 more
doaj   +1 more source

Molecular genetic analyses of human NKG2C (KLRC2) gene deletion [PDF]

International Immunology, 2004
Human NKG2A, NKG2C and NKG2E genes are located on 12p13 in the NK gene complex. We recently identified deletion of NKG2C in a Japanese population. This study was performed to identify the breakpoint, and to examine the association of NKG2C deletion with susceptibility to rheumatoid arthritis and systemic lupus erythematosus.
Miyashita, R, Tsuchiya, N, Hikami, K, Kuroki, K, Fukazawa, T, Bijl, M, Kallenberg, CGM, Hashimoto, H, Yabe, T, Tokunaga, K   +9 more
openaire   +3 more sources

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Frontiers in Immunology, 2023
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment of various haematological disorders which is associated with significantly improved survival rates.
Jagoda Siemaszko, Piotr Łacina, Donata Szymczak, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W. Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik   +16 more
doaj   +1 more source

Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors [PDF]

Immunity, 1998
While the inhibitory NK cell receptors for MHC class I express immunoreceptor tyrosine-based inhibitory motifs that recruit intracellular tyrosine phosphatases and prevent NK cell effector function, the activating NK cell receptors lack intrinsic sequences required for cellular stimulation.
Lanier, Lewis L, Corliss, Brian, Wu, Jun, Phillips, Joseph H   +3 more
openaire   +2 more sources

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point

Journal of Virology, 2021
We compared NKG2C allele and genotype distributions in subjects who remained HIV uninfected despite multiple HIV exposures (HESN subjects) with those in the group PLWH. This allowed us to determine whether NKG2C genotype influenced susceptibility to HIV infection.
Khlood Alsulami, Naomi Bolastig, Franck P. Dupuy, Tsoarello Mabanga, Louise Gilbert, Zahra Kiani, Jean-Pierre Routy, Julie Bruneau, Réjean Thomas, Cécile Tremblay, Christos M. Tsoukas, Jason Szabo, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Nicole F. Bernard   +16 more
openaire   +3 more sources