Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells [PDF]
Frontiers in Immunology, 2022 Natural killer (NK) cells are an important component of the innate immune system due to their strong ability to kill virally infected or transformed cells without prior exposure to the antigen (Ag).
Fei Gao +5 more
doaj +6 more sources
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. [PDF]
Cell Stem Cell, 2021 Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and lack of on-demand availability.
Woan KV +30 more
europepmc +6 more sources
The Frequency and Function of NKG2C+CD57+ Adaptive NK Cells in Cytomagalovirus Co-Infected People Living with HIV Decline with Duration of Antiretroviral Therapy [PDF]
Viruses, 2023 Human cytomegalovirus (CMV) infection drives the expansion and differentiation of natural killer (NK) cells with adaptive-like features. We investigated whether age and time on antiretroviral therapy (ART) influenced adaptive NK cell frequency and ...
Khlood Alsulami +10 more
doaj +2 more sources
Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques [PDF]
Frontiers in Immunology, 2022 Previous research on adaptive NK cells in rhesus macaques suffered from the lack of specific antibodies to differentiate between inhibitory CD94/NKG2A and stimulatory CD94/NKG2C heterodimeric receptors. Recently we reported an expansion of NKG2C receptor-
Mohammad Zahidul Hasan +10 more
doaj +2 more sources
Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum [PDF]
Frontiers in Immunology, 2020 Human adaptive natural killer (NK) cells have diminished reliance on accessory cytokines for their activation whilst being efficiently activated by infected host cells in conjunction with pathogen specific antibodies.
Samuel Sherratt +4 more
doaj +2 more sources
Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes [PDF]
Frontiers in Immunology, 2019 Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity.
Marcel Costa-García +6 more
doaj +2 more sources
Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response
Frontiers in Cellular and Infection Microbiology, 2020 Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent ...
Stephen Pierce +4 more
doaj +3 more sources
Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma
Cells, 2021 Hepatocellular carcinoma (HCC) is a global health burden with increasing incidence, poor prognosis and limited therapeutic options. Natural killer (NK) cells exhibit potent anti-tumoral activity and therefore represent potential targets for ...
Charlotte Rennert +15 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2022 Background Natural killer (NK) cells hold great promise as a source for allogeneic cell therapy against hematological malignancies, including acute myeloid leukemia (AML).
Shuo Li +29 more
doaj +1 more source
NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?
Frontiers in Cellular and Infection Microbiology, 2020 Mounting experimental evidence hints to an import role for natural killer (NK) cells in adaptive immune responses to pathogens. NK cells with adaptive features are heterogeneous and belong to different subsets according to their phenotype as well as the ...
Victoria Stary +3 more
doaj +1 more source