Results 1 to 10 of about 356,675 (111)

Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells

Frontiers in Immunology, 2022
Natural killer (NK) cells are an important component of the innate immune system due to their strong ability to kill virally infected or transformed cells without prior exposure to the antigen (Ag).
Fei Gao, Zhengwei Zhou, Ying Lin, Guang Shu, Gang Yin, Tianxiang Zhang   +5 more
doaj   +2 more sources

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

Cell Stem Cell, 2021
Summary Select subsets of immune effector cells have the highest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector cell persistence and lack of on ...
Tom T Lee, Karrune Woan, Jeffrey S. Miller   +2 more
exaly   +2 more sources

Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia

Journal for ImmunoTherapy of Cancer, 2022
Background Natural killer (NK) cells hold great promise as a source for allogeneic cell therapy against hematological malignancies, including acute myeloid leukemia (AML).
Shuo Li, Bin Zhang, Jeffrey S Miller, Veronika Kremer, Bahram Valamehr, Frank Cichocki, Martin Felices, Karl-Johan Malmberg, Hans-Gustaf Ljunggren, Björn Önfelt, Laura Bendzick, Evren Alici, Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Minoru Kanaya, Pouria Momayyezi, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Geir Tjonnfjord, Stéphanie Berggren, Kristina Wikström, Pontus Blomberg, Petter Höglund, Andreas Björklund, Quirin Hammer, Lise Kveberg, Ebba Sohlberg   +29 more
doaj   +2 more sources

Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes

Frontiers in Immunology, 2019
Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity.
Marcel Costa-García, Michelle Ataya, Manuela Moraru, Carlos Vilches, Miguel López-Botet, Miguel López-Botet, Aura Muntasell   +6 more
doaj   +2 more sources

Balancing act: the complex role of NK cells in immune regulation

Frontiers in Immunology, 2023
Natural killer (NK) cells, as fundamental components of innate immunity, can quickly react to abnormalities within the body. In-depth research has revealed that NK cells possess regulatory functions not only in innate immunity but also in adaptive ...
Hongwei Jiang, Hongwei Jiang, Hongwei Jiang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +5 more
doaj   +2 more sources

FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells

iScience, 2020
Summary: Adaptive human natural killer (NK) cells display significantly enhanced responsiveness to a broad-range of antibody-bound targets through the engagement of CD16 compared to conventional NK cells, yet direct reactivity against tumor targets is ...
Weiru Liu, Jeannine M. Scott, Emma Langguth, Helena Chang, Peter H. Park, Sungjin Kim   +5 more
doaj   +2 more sources

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

Immunity, 2021
Summary Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway.
Georg Gasteiger, Matthias Schiemann, Joseph C Sun   +2 more
exaly   +2 more sources

SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression

Emerging Microbes and Infections
HLA-E expression plays a central role for modulation of NK cell function by interaction with inhibitory NKG2A and stimulatory NKG2C receptors on canonical and adaptive NK cells, respectively.
Mohammad Zahidul Hasan, Maren Claus, Nadine Krüger, Sarah Reusing, Eline Gall, Christina Bade-Döding, Armin Braun, Carsten Watzl, Markus Uhrberg, Lutz Walter   +9 more
doaj   +2 more sources

CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques

Cell Reports, 2018
Summary: Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg)
Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, R. Keith Reeves   +8 more
doaj   +2 more sources

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Nature Communications, 2021
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of SIVagm infection in secondary lymphoid tissues.
N. Huot, P. Rascle, Caroline Petitdemange, V. Contreras, C. Stürzel, E. Baquero, J. Harper, C. Passaes, R. Legendre, Hugo Varet, Y. Madec, U. Sauermann, C. Stahl-Hennig, J. Nattermann, A. Sáez-Cirión, R. Le Grand, R. Reeves, M. Paiardini, F. Kirchhoff, B. Jacquelin, M. Müller-Trutwin   +20 more
semanticscholar   +1 more source