Scientific Reports, 2023 Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control.
Aljawharah Alrubayyi +18 more
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A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG. [PDF]
, 2011 Subsets of NK cells can have distinct functions. Here, we report that >25% of human peripheral blood NK cells express HLA-DR after culture with IL-2.
Emma L. Wise +18 more
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Cell Reports, 2016 Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C ...
Lisa L. Liu +17 more
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Natural killer cells- from innate cells to the discovery of adaptability
Frontiers in Immunology, 2023 Natural Killer (NK) cells have come a long way since their first description in the 1970’s. The most recent reports of their adaptive-like behavior changed the way the immune system dichotomy is described.
Débora Basílio-Queirós +1 more
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In depth characterization of human CMV-driven adaptive NK cells through mass spectrometry and flow cytometry analyses [PDF]
, 2023 Human Natural killer (NK) cells are a population of innate lymphocytes, usually short-lived and rapidly responding against viral infections and tumors. However, upon cytomegalovirus (CMV) infection, NK cells reveal unexpected adaptive traits typical of T
Di Silvestre Dario +10 more
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Adaptive Features of Natural Killer Cells in Multiple Sclerosis
Frontiers in Immunology, 2019 Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile.
Antía Moreira +14 more
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Adaptive NK cell reconstitution is associated with better clinical outcomes [PDF]
JCI Insight, 2019 BACKGROUND. Human cytomegalovirus (CMV) reactivation is a common occurrence early after transplant and is associated with heterogeneous NK cell subset expansion. These adaptive NK cell expansions are highly variable between recipients, with respect to magnitude and relative frequencies of adaptive NK cell ...
Frank Cichocki +10 more
openaire +2 more sources
Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Irene Tirado-González +58 more
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Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70 [PDF]
, 2005 Bovine NK cells have recently been characterized and the present study describes the interaction between NK cells, antigen-presenting cells, and secreted mycobacteriall proteins.
Jungersen, Gregers +15 more
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]
, 2007 Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten +34 more
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