Results 31 to 40 of about 5,867,069 (283)
Unraveling exhaustion in adaptive and conventional NK cells
Journal of Leukocyte Biology, 2020 Abstract Immune exhaustion in T cells significantly impacts their ability to control malignancies and infections, and its discovery has led to revolutionary therapies for cancer in the form of checkpoint blockade. NK cells, like T cells, are lymphocytes that recognize virally infected and malignantly transformed cells.
Aimee M Merino +3 more
openaire +3 more sources
Blood, 2017 Natural killer (NK) cells have long been considered short-lived effectors of innate immunity. However, recent animal models and human studies suggest that subsets of NK cells have adaptive features.
M. Corat +10 more
semanticscholar +2 more sources
Inflammasome-Dependent Induction of Adaptive NK Cell Memory [PDF]
Immunity, 2016 Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-lasting, melanocyte-specific immune ...
van den Boorn, J. +9 more
openaire +3 more sources
Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses
Cell Reports, 2020 Summary: Natural killer (NK) cells play a critical role in controlling viral infections, coordinating the response of innate and adaptive immune systems. They also possess certain features of adaptive lymphocytes, such as undergoing clonal proliferation.
Carlos Diaz-Salazar, Joseph C. Sun
doaj +1 more source
Activation of natural killer cells during microbial infections. [PDF]
, 2011 Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M +8 more
core +1 more source
NK cells expansion in vitro is followed by loss of inhibitory KIR expression
Медицинская иммунология, 2023 NK cells are innate lymphocytes that are able to eliminate altered cells, which makes them promising for the immunotherapy of viral diseases and tumors. The NK cell population is characterized by high phenotypic and functional diversity.
N. A. Alekseeva +5 more
doaj +1 more source
Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Irene Tirado-González +58 more
core +2 more sources
Scientific Reports, 2023 Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control.
Aljawharah Alrubayyi +18 more
doaj +1 more source
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria
Journal of Experimental Medicine, 2019 Plasmodium falciparum–infected individuals in a malaria-endemic region have an abundance of adaptive NK cells that correlates with resistance to malaria. Adaptive NK cells dominate antibody-dependent responses to P.
G. Hart +12 more
semanticscholar +1 more source
Science Translational Medicine, 2023 Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan children.
Maureen C. Ty +30 more
semanticscholar +1 more source