Results 41 to 50 of about 5,867,069 (283)

IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study [PDF]

, 2011
In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation.
Claudia Brehm, Bader Peter, Soerensen, Jan, Klingebiel Thomas, Seidl, Christian, Christian Seidl, Petra S. A. Becker, Bremm Melanie, Koehl Ulrike, Becker, Petra S. A., Jakob R. Passweg, Sabine Huenecke, Andrea Quaiser, Peter Bader, Koehl, Ulrike, Thomas Klingebiel, Ulrike Koehl, Jakob R Passweg, Brehm Claudia, Jan Soerensen, Hermann Kreyenberg, Schwabe Dirk, Becker Petra S. A., Brehm, Claudia, Quaiser, Andrea, Petra S A Becker, Bader, Peter, Sörensen, Jan, Mühl Heiko, Stephan Kloess, Huenecke, Sabine, Mühl, Heiko, Klingebiel, Thomas, Esser Ruth, Klöß, Stephan, Esser, Ruth, Hünecke, Sabine, Kloess, Stephan, Huenecke Sabine, Kreyenberg Hermann, Seidl Christian, Melanie Bremm, Kreyenberg, Hermann, Bremm, Melanie, Heiko Mühl, Ruth Esser, Dirk Schwabe, Soerensen Jan, Köhl, Ulrike, Quaiser Andrea, Passweg, Jakob R., Schwabe, Dirk, Kloess Stephan, Passweg Jakob R.   +53 more
core   +1 more source

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Cell Reports, 2016
Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C ...
Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat   +17 more
doaj   +1 more source

Natural killer cells- from innate cells to the discovery of adaptability

Frontiers in Immunology, 2023
Natural Killer (NK) cells have come a long way since their first description in the 1970’s. The most recent reports of their adaptive-like behavior changed the way the immune system dichotomy is described.
Débora Basílio-Queirós, Eva Mischak-Weissinger   +1 more
doaj   +1 more source

A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG. [PDF]

, 2011
Subsets of NK cells can have distinct functions. Here, we report that >25% of human peripheral blood NK cells express HLA-DR after culture with IL-2.
Emma L. Wise, Riley, Eleanor M, Pease, James E, Horowitz, Amir, Evans, J Henry, Eleanor M. Riley, Riley, Eleanor M., James E. Pease, Wise, Emma L., Pease, James E., Davis, Daniel M., Wise, Emma L, Davis, Daniel M, J. Henry Evans, Mehrabi, Maryam, Maryam Mehrabi, Daniel M. Davis, Amir Horowitz, Evans, J. Henry   +18 more
core   +1 more source

Adaptive Features of Natural Killer Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile.
Antía Moreira, Antía Moreira, Antía Moreira, Elisenda Alari-Pahissa, Elvira Munteis, Andrea Vera, Ana Zabalza, Mireia Llop, Noelia Villarrubia, Marcel Costa-García, Roberto Álvarez-Lafuente, Luisa María Villar, Miguel López-Botet, Miguel López-Botet, Jose E. Martínez-Rodríguez   +14 more
doaj   +1 more source

NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken [PDF]

, 2001
Non-mammalian NK cells have not been characterized in detail; however, their analysis is essential for the understanding of the NK cell receptor phylogeny.
Manfred Stangassinger, Göbel, Thomas W. F., Stangassinger, Manfred, Kaspers, Bernd, Thomas W. F. Göbel, Bernd Kaspers   +5 more
core   +1 more source

NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity

Science Translational Medicine, 2022
T cell–directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen the clinical benefit of immunotherapies.
N. Kirchhammer, Marcel P. Trefny, Marina Natoli, D. Brücher, Sheena N. Smith, F. Werner, Victoria Koch, D. Schreiner, E. Bartoszek, M. Buchi, Markus Schmid, Daniel Breu, K. Hartmann, Polina Zaytseva, D. Thommen, H. Läubli, Jan P. Böttcher, M. Stanczak, Abhishek S. Kashyap, A. Plückthun, A. Zippelius   +20 more
semanticscholar   +1 more source

Targeting Natural Killer Cells for Improved Immunity and Control of the Adaptive Immune Response

Frontiers in Cellular and Infection Microbiology, 2020
Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent ...
Stephen Pierce, Eric S. Geanes, Todd Bradley, Todd Bradley, Todd Bradley   +4 more
doaj   +1 more source

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +2 more sources

Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

Cell Reports, 2018
Adaptive NK cells are characterized by profound alterations in multiple signaling molecules, transcription factors, and epigenetic modifications compared with canonical NK cells.
Alexander Rölle, Marten Meyer, Silvia Calderazzo, D. Jäger, F. Momburg   +4 more
semanticscholar   +1 more source