Results 61 to 70 of about 103,353 (290)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques

Cell Reports, 2018
Summary: Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg)
Spandan V. Shah, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, R. Keith Reeves   +8 more
doaj   +1 more source

Harnessing Memory NK Cell to Protect Against COVID-19

Frontiers in Pharmacology, 2020
The worldwide struggle against the coronavirus disease 2019 (COVID-19) as a public health crisis continues to sweep across the globe. Up to now, effective antiviral treatment against COVID-19 is not available.
Saeede Soleimanian, Ramin Yaghobi
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The role of coronin 1 during cell mediated immune responses [PDF]

, 2013
Coronin 1 is one of 7 mammalian isoforms member of the evolutionary conserved WD40-repeat proteins that are involved in a variety of activities such a cell migration and cytokinesis.
Tchang, Vincent Sam Yong
core   +1 more source

Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients

Frontiers in Immunology, 2015
Adaptive natural killer (NK) cell responses to human cytomegalovirus (CMV) infection are characterized by the expansion of NKG2C+ NK cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs). Here, we set out to study the
vivien eBeziat, vivien eBeziat, Marwan eSleiman, Jodie eGoodridge, Jodie eGoodridge, Mari eKaarbo, lisa eliu, Halvor eRollag, hans-gustaf eljunggren, jacques ezimmer, Karl-Johan eMalmberg, Karl-Johan eMalmberg   +11 more
doaj   +1 more source

NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Frontiers in Immunology
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa. It is hypothesized that NK cells in the endometrium are precursors for decidual NK cells present during pregnancy.
Feyaerts, D., Benner, M., Comitini, G., Shadmanfar, W., van der Heijden, O.W.H., Joosten, I., Joosten, I., van der Molen, R.G.   +7 more
openaire   +5 more sources

Adaptive NK cell response to human cytomegalovirus: Facts and open issues

Seminars in Immunology, 2023
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the differentiation and persistent expansion of a mature NK cell subset which displays a characteristic phenotypic and functional profile hallmarked by expression of the HLA-E-specific CD94/NKG2C activating receptor.
Miguel López-Botet, Andrea De-Maria, Aura Muntasell, Mariella Della Chiesa, Carlos Vilches   +4 more
openaire   +4 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells [PDF]

, 2017
Manipulation of human natural killer (NK) cell repertoires promises more effective strategies for NK cell–based cancer immunotherapy. A subset of highly differentiated NK cells, termed adaptive NK cells, expands naturally in vivo in response to human ...
Liu, Lisa L.,, Vivien Béziat, Aline Pfefferle, Karl-Johan Malmberg, Vincent Y.S. Oei, Marie Schaffer, Dan Grandér, Beziat, Vivien,, Pfefferle, Aline,, Lisa L. Liu, Oei, Vincent Y. S.,, Grander, Dan,, Malmberg, Karl-Johan,, Heyman, Mats,, Hellstrom-Lindberg, Eva,, Sören Lehmann, Lehmann, Sören,, Eva Hellström-Lindberg, Schaffer, Marie,, Stefan Söderhäll, Mats Heyman, Soderhall, Stefan,   +21 more
core   +1 more source