Results 61 to 70 of about 5,867,069 (283)

267 Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: The primary objective of this study was to define the transcriptomes and transcriptional regulatory network required for the development and function of adaptive Natural Killer (NK) cells in donors with latent human cytomegalovirus ...
Mohamed Khalil, Scott Terhune, Subramaniam Malarkannan   +2 more
doaj   +1 more source

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

Genetic modification and effector functions of natural killer cells in acute myeloid leukemia [PDF]

, 2006
Acute myeloid leukemia (AML) is characterized by a poor long-term outcome in the majority of patients following conventional treatment with chemotherapy.
Siegler, Uwe
core   +1 more source

Single-cell profiling aligns CD56bright and cytomegalovirus-induced adaptive natural killer cells to a naïve-memory relationship

Frontiers in Immunology
Development of antigen-specific memory upon pathogen exposure is a hallmark of the adaptive immune system. While natural killer (NK) cells are considered part of the innate immune system, humans exposed to the chronic viral pathogen cytomegalovirus (CMV)
M. Kazim Panjwani, Simon Grassmann, Rosa Sottile, Jean-Benoît Le Luduec, Theodota Kontopoulos, Kattria van der Ploeg, Joseph C. Sun, Katharine C. Hsu, Katharine C. Hsu   +8 more
doaj   +1 more source

Natural Killer Cells in Multiple Sclerosis: Entering the Stage

Frontiers in Immunology, 2022
Studies investigating the immunopathology of multiple sclerosis (MS) have largely focused on adaptive T and B lymphocytes. However, in recent years there has been an increased interest in the contribution of innate immune cells, amongst which the natural
Jarne Beliën, An Goris, Patrick Matthys
doaj   +1 more source

IL-2–dependent adaptive control of NK cell homeostasis [PDF]

Journal of Experimental Medicine, 2013
Activation and expansion of T and B lymphocytes and myeloid cells are controlled by Foxp3+ regulatory T cells (T reg cells), and their deficiency results in a fatal lympho- and myeloproliferative syndrome. A role for T reg cells in the homeostasis of innate lymphocyte lineages remained unknown.
Gasteiger, Georg, Hemmers, Saskia, Bos, Paula D., Sun, Joseph C., Rudensky, Alexander Y.   +4 more
openaire   +2 more sources

Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques

Frontiers in Immunology, 2022
Previous research on adaptive NK cells in rhesus macaques suffered from the lack of specific antibodies to differentiate between inhibitory CD94/NKG2A and stimulatory CD94/NKG2C heterodimeric receptors. Recently we reported an expansion of NKG2C receptor-
Mohammad Zahidul Hasan, Mohammad Zahidul Hasan, Charlotte Höltermann, Charlotte Höltermann, Beatrix Petersen, Annette Schrod, Kerstin Mätz-Rensing, Artur Kaul, Gabriela Salinas, Ralf Dressel, Lutz Walter   +10 more
doaj   +1 more source

Engineering the Bridge between Innate and Adaptive Immunity for Cancer Immunotherapy: Focus on γδ T and NK Cells

Cells, 2020
Most studies on genetic engineering technologies for cancer immunotherapy based on allogeneic donors have focused on adaptive immunity. However, the main limitation of such approaches is that they can lead to severe graft-versus-host disease (GvHD).
F. Morandi, Mahboubeh Yazdanifar, C. Cocco, A. Bertaina, I. Airoldi   +4 more
semanticscholar   +1 more source

The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation

Science immunology, 2021
Epigenetic and functional analyses of human NK cells identify a role for Bcl11b in canonical and adaptive NK cell differentiation. Human NK cell circuitry Natural killer (NK) cells are innate immune effector cells that undergo differentiation and ...
T. D. Holmes, R. Pandey, Eric Y. Helm, H. Schlums, Hongya Han, T. Campbell, Theodore T. Drashansky, Samuel C. C. Chiang, Cheng-Ying Wu, Christine Tao, M. Shoukier, E. Tolosa, S. von Hardenberg, Miao Sun, C. Klemann, R. Marsh, Colleen M. Lau, Yin Lin, Joseph C. Sun, R. Månsson, Frank Cichocki, D. Avram, Y. Bryceson   +22 more
semanticscholar   +1 more source

HIV-1 adaptation to NK-cell-mediated immune pressure

Nature, 2011
Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and inhibitory receptors. Epidemiological and functional studies have recently suggested that NK cells can also contribute to the control of HIV-1 infection through recognition of virally infected cells
Alter, Galit, Heckerman, David, Schneidewind, Arne, Fadda, Lena, Kadie, Carl M., Carlson, Jonathan M., Oniangue-Ndza, Cesar, Martin, Maureen, Li, Bin, Khakoo, Salim I., Carrington, Mary, Allen, Todd M., Altfeld, Marcus   +12 more
openaire   +4 more sources