Results 71 to 80 of about 5,867,069 (283)
The role of natural killer cells in adaptive immune responses [PDF]
Human natural killer (NK) cells have been shown to respond to numerous pathogenic stimuli, producing IFN-y as well as cytolytic effector molecules such as perforin and granzymes.
Horowitz, Amir
core +1 more source
Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection [PDF]
, 2010 NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill ...
Richard J. Gilson +50 more
core +1 more source
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells
Nature Immunology, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes undetectable in upper airways after a few days or weeks postinfection.
N. Huot +13 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 The immune system provides full protection for the body by specifically identifying ‘self’ and removing ‘others’; thus protecting the body from diseases.
Ya-long Yang +11 more
semanticscholar +1 more source
Development of the adaptive NK cell response to human cytomegalovirus in the context of aging [PDF]
Mechanisms of Ageing and Development, 2016 Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence ...
López-Botet, M. (Miguel) +5 more
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation
JCI Insight, 2022 CMV infection remains an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several investigators have reported that adaptive NKG2C+ NK cells persistently expand during CMV reactivation.
Xing-Xing Yu +16 more
doaj +1 more source
Journal of Immunology, 2015 Mass cytometry was used to investigate the effect of CMV reactivation on lymphocyte reconstitution in hematopoietic cell transplant patients. For eight transplant recipients (four CMV negative and four CMV positive), we studied PBMCs obtained 6 mo after ...
A. Horowitz +6 more
semanticscholar +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Harnessing Memory NK Cell to Protect Against COVID-19
Frontiers in Pharmacology, 2020 The worldwide struggle against the coronavirus disease 2019 (COVID-19) as a public health crisis continues to sweep across the globe. Up to now, effective antiviral treatment against COVID-19 is not available.
Saeede Soleimanian, Ramin Yaghobi
doaj +1 more source