Results 71 to 80 of about 103,353 (290)

Mapping NK cell diversity in response to COVID-19 and mRNA vaccination

Scientific Reports
Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood.
Yosuke Kishi, Yu-Chen Liu, Masakazu Ishikawa, Maika Yamashita, Hisatake Matsumoto, Hiroshi Ogura, Shuhei Sakakibara, Daisuke Okuzaki   +7 more
doaj   +1 more source

The Role of Natural Killer Cells in Autoimmune Diseases

Frontiers in Immunology, 2021
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common lymphoid progenitors, were discovered in early 1970’s. They are members of innate immunity and were initially defined by their strong cytotoxicity against virus ...
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz   +7 more
doaj   +1 more source

HIF1α is required for NK cell metabolic adaptation during virus infection

eLife, 2021
Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a feature of mouse NK cells during murine cytomegalovirus (MCMV) infection in vivo.
Francisco Victorino, Tarin M Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J Piersma, Elvin J Lauron, Rebecca M Davidson, Gary J Patti, Wayne M Yokoyama   +10 more
openaire   +4 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Adaptive natural killer cell expression in response to cytomegalovirus infection in blood and solid cancer

Heliyon
Natural Killer (NK) cells are conventionally thought to be an indefinite part of innate immunity. However, in a specific subset of NK cells, recent data signify an extension of their “duties” in immune surveillance and response, having characteristics of
Suruthimitra Okpoluaefe, Ida Shazrina Ismail, Rafeezul Mohamed, Norfarazieda Hassan   +3 more
doaj   +1 more source

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells. [PDF]

Blood, 2017
Key Points GATA-2 expression is restricted to hematopoietic stem and progenitor cells, leading to NK-cell progenitor deficiency in GATA2 patients.
Schlums H, Jung M, Han H, Theorell J, Bigley V, Chiang SC, Allan DS, Davidson-Moncada JK, Dickinson RE, Holmes TD, Hsu AP, Townsley D, Winkler T, Wang W, Aukrust P, Nordøy I, Calvo KR, Holland SM, Collin M, Dunbar CE, Bryceson YT.   +20 more
europepmc   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD [PDF]

, 2016
Anders Andersson,1,* Carina Malmhäll,2,* Birgitta Houltz,1 Sara Tengvall,1 Margareta Sjöstrand,2 Ingemar Qvarfordt,1 Anders Lindén,3 Apostolos Bossios2 1Respiratory Medicine and Allergology, Department of Internal Medicine and Clinical ...
Andersson, A, Tengvall, S, Tengvall S, Qvarfordt I, Houltz, B, Sjostrand, M, Qvarfordt, Ingemar,, M, Houltz B, Linden, A, Malmhäll, Carina,, Bossios, Apostolos,, Lindén, Anders,, Malmhäll C, Sjöstr, Qvarfordt, I, Tengvall, Sara,, Houltz, Birgitta,, Bossios, A,, Bossios A, Malmhall, C, Lindén A, Andersson A, Andersson, Anders,, Sjöstrand, Margareta,   +24 more
core   +1 more source

Increased proliferative response of highly differentiated CD57⁺NKG2C⁺NK cells expressing NKG2A

Медицинская иммунология
During infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva, Yu. D. Vavilova, E. I. Kovalenko   +2 more
doaj   +1 more source