Results 91 to 100 of about 5,867,069 (283)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Role of Natural Killer Cells in Autoimmune Diseases

Frontiers in Immunology, 2021
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common lymphoid progenitors, were discovered in early 1970’s. They are members of innate immunity and were initially defined by their strong cytotoxicity against virus ...
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz   +7 more
doaj   +1 more source

Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]

, 2012
Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Xiumei Chi, Lv, J., Yu Pan, Zhigang Tian, Niu, J., Juan Lv, Weihua Xiao, Yan, H., Xu, D., Zhengkun Tu, Hu, X., Chi, X., Junqi Niu, Qinglong Jin, Xiao, W., Sun, H., Hou, J., Jinlin Hou, Hongqing Yan, Haibo Sun, Tian, Z., Tu, Z., Xiaoli Hu, Jin, Q., Pan, Y., Damo Xu   +25 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Adaptive natural killer cell expression in response to cytomegalovirus infection in blood and solid cancer

Heliyon
Natural Killer (NK) cells are conventionally thought to be an indefinite part of innate immunity. However, in a specific subset of NK cells, recent data signify an extension of their “duties” in immune surveillance and response, having characteristics of
Suruthimitra Okpoluaefe, Ida Shazrina Ismail, Rafeezul Mohamed, Norfarazieda Hassan   +3 more
doaj   +1 more source

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells [PDF]

, 2011
The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian, Bektas, Hueseyin, Heiner Wedemeyer, Wedemeyer Heiner, Suneetha, Pothakamuri Venkata, Grabowski, Jan, Michael Peter Manns, Markus Cornberg, Sarrazin, Christoph, Julia Dietz, Hueseyin Bektas, Christoph Sarrazin, Helfritz Fabian, Schlaphoff, Verena, Lunemann Sebastian, Fabian Helfritz, Suneetha Pothakamuri Venkata, Dietz, Julia, Jaroszewicz, Jerzy, Wedemeyer, Heiner, Bektas Hueseyin, Sebastian Lunemann, Pothakamuri Venkata Suneetha, Sarrazin Christoph, Manns Michael Peter, Jaroszewicz Jerzy, Jerzy Jaroszewicz, Helfritz, Fabian Arnold, Cornberg, Markus, Jan Grabowski, Schlaphoff Verena, Dietz Julia, Manns, Michael P., Verena Schlaphoff, Grabowski Jan, Cornberg Markus   +35 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Increased proliferative response of highly differentiated CD57⁺NKG2C⁺NK cells expressing NKG2A

Медицинская иммунология
During infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva, Yu. D. Vavilova, E. I. Kovalenko   +2 more
doaj   +1 more source

Sweet Is the Memory of Past Troubles: NK Cells Remember [PDF]

, 2015
Natural killer (NK) cells are important in host defense against tumors and microbial pathogens. Recent studies indicate that NK cells share many features with the adaptive immune system, and like B cells and T cells, NK cells can acquire immunological ...
Deborah W. Hendricks, Min-Oo, Gundula, Hendricks, Deborah W, Lanier, Lewis L, Gundula Min-Oo, Lewis L. Lanier   +5 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source