Results 91 to 100 of about 103,353 (290)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function [PDF]

, 2015
SummaryThe mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins after human ...
Schlums, Heinrich, Schaffer, Marie, Ljunggren, Hans-Gustaf, Han, Hongya, Bryceson, Yenan T., Tesi, Bianca, Mattsson, Kristin, Beziat, Vivien, Theorell, Jakob, Chiang, Samuel C.C., Larsson, Stella, Malmberg, Karl-Johan, Miller, Jeffrey S., Holmes, Tim D., Foley, Bree, Cichocki, Frank   +15 more
core   +1 more source

The Role of Natural Killer Cells in the Immune Response in Kidney Transplantation

Frontiers in Immunology, 2020
Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant ...
Paola Pontrelli, Federica Rascio, Giuseppe Castellano, Giuseppe Grandaliano, Giuseppe Grandaliano, Loreto Gesualdo, Giovanni Stallone   +6 more
doaj   +1 more source

HIV-1 adaptation to NK cell-mediated immune pressure

PLOS Pathogens, 2017
The observation, by Alter et al., of the enrichment of NK cell "escape" variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) cells exert selection pressure on HIV-1.
Marjet Elemans, Lies Boelen, Michael Rasmussen, Søren Buus, Becca Asquith   +4 more
openaire   +5 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Hidden talents of natural killers: NK cells in innate and adaptive immunity [PDF]

The EMBO Reports, 2009
Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells and producing immunoregulatory cytokines. Herein, we discuss recent studies that indicate that NK cells span the conventional boundaries between innate and adaptive immunity.
Megan A, Cooper, Marco, Colonna, Wayne M, Yokoyama   +2 more
openaire   +2 more sources

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core  

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity [PDF]

Leukemia, 2013
It remains unclear how the immune system affects leukemia development. To clarify the significance of the presence of immune systems in leukemia development, we transferred MLL/ENL leukemia cells into immune-competent or immune-deficient mice without any preconditioning including irradiation. The wild-type mice did not develop leukemia, whereas all the
J, Nakata, K, Nakano, A, Okumura, Y, Mizutani, H, Kinoshita, M, Iwai, K, Hasegawa, S, Morimoto, F, Fujiki, N, Tatsumi, H, Nakajima, Y, Nakae, S, Nishida, A, Tsuboi, Y, Oji, Y, Oka, H, Sugiyama, A, Kumanogoh, N, Hosen   +18 more
openaire   +2 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source