Results 111 to 120 of about 103,353 (290)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood [PDF]

, 2019
Human adaptive-like “memory” CD56 dim CD16 + NK cells in peripheral blood from cytomegalovirus-seropositive individuals have been extensively investigated in recent years and are currently explored as a treatment strategy for hematological cancers ...
Kekäläinen, E, Scharenberg, M, Nguyen, S, Marquardt, N,, Ljunggren, H-G, Mold, JE, Al-Ameri, M,, Buggert, M,, Hård, J, Wilson, JN   +9 more
core   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells

Pharmaceutics
Human cytomegalovirus (HCMV)-specific adaptive NK cells are capable of recognizing viral peptides presented by HLA-E on infected cells via the NKG2C receptor. Using retroviral transduction, we have generated a K562-cell-based line expressing HLA-E in the
Nadezhda A. Alekseeva, Maria A. Streltsova, Julia D. Vavilova, Maria O. Ustiuzhanina, Anastasia I. Palamarchuk, Anna A. Boyko, Nikita D. Timofeev, Alexey I. Popodko, Elena I. Kovalenko   +8 more
doaj   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Anti-CD94-induced expansion of highly functional adaptive NKG2C+NKG2A−CD57+selfKIR+ NK cells from CMV-seropositive healthy donors [PDF]

Human Natural Killer (NK) cells are innate lymphocytes, short-living and providing rapid responses against viral infections and tumors. Adaptive NK cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection, characterized by the ...
Della Chiesa M., Carlomagno S., Falco M., Caruana I., Cantoni C., Muccio L., Vitale M., Giordano C., Sivori S.   +8 more
core  

Associação de polimorfismos em genes envolvidos na regulação da atividade das células NK (Natural Killer) no desenvolvimento do câncer de mama [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2014.Introdução: O câncer de mama possui etiologia variada, sendo influenciada ...
Back, Lia Kubelka de Carlos
core  

CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors

Frontiers in Immunology
BackgroundAdaptive human natural killer (NK) cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection. They are characterized by CD94/NKG2C expression, a mature CD57+KIR+NKG2A– phenotype, a prolonged lifespan, and remarkable ...
Chiara Giordano, Simona Carlomagno, Simona Carlomagno, Michela Falco, Claudia Cantoni, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Franco Locatelli, Cristina Bottino, Cristina Bottino, Simona Sivori, Simona Sivori, Mariella Della Chiesa, Mariella Della Chiesa   +20 more
doaj   +1 more source

Highly Entangled Bottlebrush Polymer Networks

Advanced Materials, EarlyView.
Bottlebrush polymers are difficult to entangle, enabling ultrasoft yet brittle networks. We report highly entangled bottlebrush elastomers that remain ultrasoft (∼1 kPa) yet stretch to ∼1800% and exhibit exceptional fatigue resistance. Their intrinsic fatigue strength—fatigue threshold normalized by modulus—surpasses that of highly entangled linear ...
Myoeum Kim, Baiqiang Huang, Shiwang Cheng, Li‐Heng Cai   +3 more
wiley   +1 more source

Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48

Cell Reports
Summary: Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be “adaptive” or “memory” NK cells.
Rui Li, Cristian Camilo Galindo, Dominique Davidson, Huaijian Guo, Ming-Chao Zhong, Jin Qian, Bin Li, Zsolt Ruzsics, Colleen M. Lau, Timothy E. O'Sullivan, Silvia M. Vidal, Joseph C. Sun, André Veillette   +12 more
doaj   +1 more source