Results 81 to 90 of about 5,867,069 (283)

HIF1α is required for NK cell metabolic adaptation during virus infection

eLife, 2021
Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a feature of mouse NK cells during murine cytomegalovirus (MCMV) infection in vivo.
Francisco Victorino, Tarin M Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J Piersma, Elvin J Lauron, Rebecca M Davidson, Gary J Patti, Wayne M Yokoyama   +10 more
openaire   +4 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Infection induces tissue resident memory NK cells that safeguard tissue health

Immunity, 2023
SUMMARY Tissue health is dictated by the capacity to respond to perturbations and then return to homeostasis. Mechanisms that initiate, maintain, and regulate immune responses in tissues are therefore essential.
I. Schuster, Xavier Y. X. Sng, Colleen M. Lau, D. Powell, Orr-El Weizman, Peter Fleming, Georgia E G Neate, V. Voigt, Sam Sheppard, Andreas I. Maraskovsky, Sheridan Daly, M. Koyama, Geoffrey R. Hill, S. Turner, Timothy E. O'Sullivan, Joseph C. Sun, C. Andoniou, M. Degli-Esposti   +17 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Mapping NK cell diversity in response to COVID-19 and mRNA vaccination

Scientific Reports
Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood.
Yosuke Kishi, Yu-Chen Liu, Masakazu Ishikawa, Maika Yamashita, Hisatake Matsumoto, Hiroshi Ogura, Shuhei Sakakibara, Daisuke Okuzaki   +7 more
doaj   +1 more source

Polyclonal Expansion of NKG2C+ NK Cells in TAP-deficient Patients

Frontiers in Immunology, 2015
Adaptive natural killer (NK) cell responses to human cytomegalovirus (CMV) infection are characterized by the expansion of NKG2C+ NK cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs). Here, we set out to study the
vivien eBeziat, vivien eBeziat, Marwan eSleiman, Jodie eGoodridge, Jodie eGoodridge, Mari eKaarbo, lisa eliu, Halvor eRollag, hans-gustaf eljunggren, jacques ezimmer, Karl-Johan eMalmberg, Karl-Johan eMalmberg   +11 more
doaj   +1 more source

Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)

International Journal of Molecular Sciences, 2020
Natural killer (NK) cells play a significant and vital role in the first line of defense against infection through their ability to target cells without prior sensitization.
Samantha A. Barnes, Ophelia Schilizzi, Katherine M. Audsley, Hannah V. Newnes, B. Foley   +4 more
semanticscholar   +1 more source

Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model

Frontiers in Pharmacology, 2021
Recently, adaptive NK cell therapy has become a promising treatment but has limited efficacy as a monotherapy. The identification of immune checkpoint inhibitor (ICI) molecules has opened a new horizon of immunotherapy.
S. Abdolahi, Zeinab Ghazvinian, S. Muhammadnejad, M. Ahmadvand, H. A. Aghdaei, S. Ebrahimi-Barough, J. Ai, M. Zali, J. Verdi, Kaveh Baghaei   +9 more
semanticscholar   +1 more source

NK cell receptor profiling of endometrial and decidual NK cells reveals pregnancy-induced adaptations

Frontiers in Immunology
Natural killer (NK) cells, with a unique NK cell receptor phenotype, are abundantly present in the non-pregnant (endometrium) and pregnant (decidua) humanuterine mucosa. It is hypothesized that NK cells in the endometrium are precursors for decidual NK cells present during pregnancy.
Feyaerts, D., Benner, M., Comitini, G., Shadmanfar, W., van der Heijden, O.W.H., Joosten, I., Joosten, I., van der Molen, R.G.   +7 more
openaire   +5 more sources

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]

, 2010
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Brzostek, Joanna, Nigel J Burroughs, Stephane Oddos, Nigel J. Burroughs, Van der Merwe, Philip Anton, Maryam Mehrabi, Daniel M Davis, Koehler, Karsten, Daniel M. Davis, Alice Harrison, Harrison Alice, Eissmann, Philipp, Shiqiu Xiong, Davis, Daniel M., Köhler Karsten, Köhler, Karsten, Cordoba, Shaun-Paul, Philipp Eissmann, Oddos, Stephane, Xiong, Shiqiu, Miloserdov, Vladimir, Gould Keith, Philip Anton van der Merwe, Mehrabi, Maryam, Xiong Shiqiu, Burroughs, Nigel J, Davis Daniel M., Miloserdov Vladimir, van der Merwe Philip Anton, Mehrabi Maryam, Karsten Köhler, Burroughs Nigel J., Harrison, Alice, Joanna Brzostek, Cordoba, Shaun Paul, Oddos Stephane, Shaun-Paul Cordoba, Burroughs, Nigel J., Cordoba Shaun-Paul, Davis, Daniel M, Burroughs, Nigel John, Gould, Keith, Keith Gould, Vladimir Miloserdov, Eissmann Philipp, Brzostek Joanna, Gould K., Harrison A., Köhler K., Miloserdov V., Oddos S., Cordoba S.-P., Xiong S., Davis D.M., Mehrabi M., Brzostek J., Burroughs N.J., van der Merwe P.A., Eissmann P.   +58 more
core   +1 more source