Results 81 to 90 of about 103,353 (290)
NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy
Frontiers in Immunology, 2022 Environmental conditions greatly shape the phenotype and function of immune cells. Specifically, hypoxic conditions that exist within tissues and organs have been reported to affect both the adaptive and the innate immune system.
Irene Garcés-Lázaro +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs. [PDF]
Blood, 2017 Natural killer (NK) cells have long been considered short-lived effectors of innate immunity. However, recent animal models and human studies suggest that subsets of NK cells have adaptive features.
Corat MA +10 more
europepmc +2 more sources
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Supplementary Figures 1-5 from Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells [PDF]
, 2017 Supplementary Figure 1. Expansion of adaptive NK cells from C1/C2 donors depends on original imprint. Supplemental Figure 2. Selective expansion of NKG2C NKG2A- NK cells depends on stimulation with HLA-E expressing feeder cells.
Vivien Béziat (204259) +10 more
core +1 more source
Adaptive Natural Killer Cells Integrate Interleukin-18 during Target-Cell Encounter
Frontiers in Immunology, 2018 Human cytomegalovirus (HCMV) infection induces adaptations in the natural killer (NK)-cell compartment. Expanded subsets of adaptive NK cells display potent effector functions against cellular targets, despite their apparent unresponsiveness to ...
Quirin Hammer +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley +1 more source
The 'T-cell-ness' of NK cells: unexpected similarities between NK cells and T cells. [PDF]
, 2011 International audienceNK cells are considered as prototypical innate immune cells. However, recent discoveries have tended to refine the dogmatic concepts of innate and adaptive immunity. In many ways, NK cells are highly related to T cells and represent
Vivier, Eric +5 more
core +1 more source
Frontiers in Immunology, 2018 In human natural killer (NK) cells, human cytomegalovirus (HCMV) has been shown to be a driving force capable of inducing the expansion of a highly differentiated NKG2C+CD57+ subset, persisting over time in both HCMV+ healthy subjects and umbilical cord ...
Letizia Muccio +12 more
doaj +1 more source
IL-15 participates in the respiratory innate immune response to influenza virus infection. [PDF]
PLoS ONE, 2012 Following influenza infection, natural killer (NK) cells function as interim effectors by suppressing viral replication until CD8 T cells are activated, proliferate, and are mobilized within the respiratory tract.
Katherine C Verbist +4 more
doaj +1 more source