Results 21 to 30 of about 103,353 (290)

ARID5B regulates metabolic programming in human adaptive NK cells. [PDF]

J Exp Med, 2018
Natural killer (NK) cells with adaptive immunological properties expand and persist in response to human cytomegalovirus. Here, we explored the metabolic processes unique to these cells. Adaptive CD3−CD56dimCD57+NKG2C+ NK cells exhibited metabolic hallmarks of lymphocyte memory, including increased oxidative mitochondrial respiration, mitochondrial ...
Cichocki F, Wu CY, Zhang B, Felices M, Tesi B, Tuininga K, Dougherty P, Taras E, Hinderlie P, Blazar BR, Bryceson YT, Miller JS.   +11 more
europepmc   +4 more sources

Balancing act: the complex role of NK cells in immune regulation

Frontiers in Immunology, 2023
Natural killer (NK) cells, as fundamental components of innate immunity, can quickly react to abnormalities within the body. In-depth research has revealed that NK cells possess regulatory functions not only in innate immunity but also in adaptive ...
Hongwei Jiang, Hongwei Jiang, Hongwei Jiang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +5 more
doaj   +1 more source

Natural Killer Cell Responses during Human γ-Herpesvirus Infections

Vaccines, 2021
Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the β-herpesvirus human cytomegalovirus (CMV) drives the accumulation of adaptive NKG2C-positive NK cells, the human γ-herpesvirus Epstein–Barr virus (EBV) expands early ...
Christian Münz
doaj   +1 more source

Unraveling exhaustion in adaptive and conventional NK cells

Journal of Leukocyte Biology, 2020
Abstract Immune exhaustion in T cells significantly impacts their ability to control malignancies and infections, and its discovery has led to revolutionary therapies for cancer in the form of checkpoint blockade. NK cells, like T cells, are lymphocytes that recognize virally infected and malignantly transformed cells.
Aimee M Merino, Hansol Kim, Jeffrey S Miller, Frank Cichocki   +3 more
openaire   +3 more sources

Inflammasome-Dependent Induction of Adaptive NK Cell Memory [PDF]

Immunity, 2016
Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-lasting, melanocyte-specific immune ...
van den Boorn, Jasper G., Jakobs, Christopher, Hagen, Christian, Renn, Marcel, Luiten, Rosalie M., Melief, Cornelis J. M., Tüting, Thomas, Garbi, Natalio, Hartmann, Gunther, Hornung, Veit   +9 more
openaire   +2 more sources

Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses

Cell Reports, 2020
Summary: Natural killer (NK) cells play a critical role in controlling viral infections, coordinating the response of innate and adaptive immune systems. They also possess certain features of adaptive lymphocytes, such as undergoing clonal proliferation.
Carlos Diaz-Salazar, Joseph C. Sun
doaj   +1 more source

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk [PDF]

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

NK cells expansion in vitro is followed by loss of inhibitory KIR expression

Медицинская иммунология, 2023
NK cells are innate lymphocytes that are able to eliminate altered cells, which makes them promising for the immunotherapy of viral diseases and tumors. The NK cell population is characterized by high phenotypic and functional diversity.
N. A. Alekseeva, M. O. Ustyuzhanina, M. A. Streltsova, M. V. Grechikhina, G. V. Lutsenko, E. I. Kovalenko   +5 more
doaj   +1 more source

Proteomic characterization of human CMV-driven adaptive NK cells [PDF]

, 2022
Human Natural killer (NK) cells are a lymphocyte population of innate immunity, usually short-living and capable of providing rapid responses against viral infections and tumors without prior sensitization.
Di Silvestre Dario, Giordano Chiara, Mauri Pierluigi, Del Zotto Genny, Bartolucci Martina, Muccio Letizia, Sivori Simona, Della Chiesa Mariella, Petretto Andrea, Antonini Francesca, Lavarello Chiara   +10 more
core  

Activation of natural killer cells during microbial infections. [PDF]

, 2011
Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M, Eleanor M Riley, Amir eHorowitz, Horowitz, Amir, Stegmann, Kerstin A, Kerstin eStegmann, Amir Horowitz, Eleanor M. Riley, Kerstin A. Stegmann   +8 more
core   +1 more source