Results 21 to 30 of about 5,867,069 (283)

Redefining Memory: Building the Case for Adaptive NK Cells [PDF]

Journal of Virology, 2017
ABSTRACTClassically, natural killer (NK) cells have been defined by nonspecific innate killing of virus-infected and tumor cells. However, burgeoning evidence suggests that the functional repertoire of NK cells is far more diverse than has been previously appreciated, thus raising the possibility that there may be unexpected functional specialization ...
S. Paust, Catherine A. Blish, R. Reeves
semanticscholar   +3 more sources

Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection

Journal of Experimental Medicine, 2020
Natural killer (NK) cells are critical for protection against viruses. Diaz-Salazar et al. show that adrenergic neurons modulate the adaptive NK cell response in a cell-intrinsic manner.
C. Diaz-Salazar, Regina Bou-Puerto, Adriana M. Mujal, Colleen M. Lau, Madlaina von Hoesslin, D. Zehn, Joseph C. Sun   +6 more
semanticscholar   +3 more sources

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Blood, 2017
Key Points GATA-2 expression is restricted to hematopoietic stem and progenitor cells, leading to NK-cell progenitor deficiency in GATA2 patients.
H. Schlums, Moonjung Jung, Hongya Han, J. Theorell, V. Bigley, Samuel C. C. Chiang, David S. J. Allan, J. Davidson-Moncada, R. Dickinson, T. D. Holmes, Amy P. Hsu, D. Townsley, T. Winkler, Weixin Wang, P. Aukrust, I. Nordøy, K. Calvo, S. Holland, M. Collin, C. Dunbar, Y. Bryceson   +20 more
semanticscholar   +2 more sources

Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays

Bone Marrow Transplantation, 2022
Human cytomegalovirus (HCMV) reactivation remains a relevant complication after hematopoietic stem cell transplantation (HSCT) despite the great progress made in prophylaxis and treatment.
Débora Basílio-Queirós, L. Venturini, Susanne Luther-Wolf, E. Dammann, A. Ganser, M. Stadler, C. Falk, E. Weissinger   +7 more
semanticscholar   +1 more source

Selective Expansion of NKG2C+ Adaptive NK Cells Using K562 Cells Expressing HLA-E

International Journal of Molecular Sciences, 2022
Adaptive natural killer (NK) cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs) can be expanded in vivo in response to human cytomegalovirus (HCMV) infection.
M. Phan, Jinho Kim, S. Koh, Yu‐Jin Lim, Hong-Bi Yu, Mijeong Lee, Jongming Lee, E. Kang, Hyun-Young Kim, Sang-Ki Kim, Ilwoong Hwang, D. Cho   +11 more
semanticscholar   +1 more source

Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma

Cells, 2021
Hepatocellular carcinoma (HCC) is a global health burden with increasing incidence, poor prognosis and limited therapeutic options. Natural killer (NK) cells exhibit potent anti-tumoral activity and therefore represent potential targets for ...
Charlotte Rennert, Catrin Tauber, Pia Fehrenbach, Kathrin Heim, Dominik Bettinger, Özlem Sogukpinar, Anita Schuch, Britta Franziska Zecher, Bertram Bengsch, Sven A. Lang, Peter Bronsert, Niklas K. Björkström, Stefan Fichtner-Feigl, Michael Schultheiss, Robert Thimme, Maike Hofmann   +15 more
doaj   +1 more source

The Frequency and Function of NKG2C⁺CD57⁺ Adaptive NK Cells in Cytomagalovirus Co-Infected People Living with HIV Decline with Duration of Antiretroviral Therapy

Viruses, 2023
Human cytomegalovirus (CMV) infection drives the expansion and differentiation of natural killer (NK) cells with adaptive-like features. We investigated whether age and time on antiretroviral therapy (ART) influenced adaptive NK cell frequency and ...
Khlood Alsulami, Franck P. Dupuy, Louise Gilbert, Marc Messier-Peet, Madeleine Durand, Cécile Tremblay, Jean-Pierre Routy, Julie Bruneau, Jean-Guy Baril, Benoit Trottier, Nicole F. Bernard   +10 more
doaj   +1 more source

Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical HSCT

JCI Insight, 2021
Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient curative approach for patients affected by hematologic malignancies in which the reduced intensity conditioning induces a state of immunologic tolerance between donor
Elisa Zaghi, M. Calvi, S. Puccio, Gianmarco Spata, S. Terzoli, C. Peano, Alessandra Roberto, F. De Paoli, Jasper J. P. van Beek, J. Mariotti, C. De Philippis, B. Sarina, R. Mineri, S. Bramanti, A. Santoro, V. Le-Trilling, M. Trilling, E. Marcenaro, L. Castagna, C. Di Vito, E. Lugli, D. Mavilio   +21 more
semanticscholar   +1 more source

NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?

Frontiers in Cellular and Infection Microbiology, 2020
Mounting experimental evidence hints to an import role for natural killer (NK) cells in adaptive immune responses to pathogens. NK cells with adaptive features are heterogeneous and belong to different subsets according to their phenotype as well as the ...
Victoria Stary, Georg Stary, Georg Stary, Georg Stary   +3 more
doaj   +1 more source

Natural Killer Cell Responses during Human γ-Herpesvirus Infections

Vaccines, 2021
Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the β-herpesvirus human cytomegalovirus (CMV) drives the accumulation of adaptive NKG2C-positive NK cells, the human γ-herpesvirus Epstein–Barr virus (EBV) expands early ...
Christian Münz
doaj   +1 more source