The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk [PDF]
Journal of Immunology Research, 2016 Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the adaptive immune system.
S. Gabrielli +8 more
semanticscholar +8 more sources
Innatus immunis: Evolving paradigm of adaptive NK cells
Journal of Experimental Medicine, 2022 Shemesh et al. report that the development of FcRγ−/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α.
Mohamed Khalil, Subramaniam Malarkannan
semanticscholar +3 more sources
ARID5B regulates metabolic programming in human adaptive NK cells [PDF]
Journal of Experimental Medicine, 2018 Natural killer (NK) cells with adaptive immunological properties expand and persist in response to human cytomegalovirus. Here, we explored the metabolic processes unique to these cells.
Frank Cichocki +11 more
semanticscholar +3 more sources
NK cells at the interface between innate and adaptive immunity [PDF]
Cell Death & Differentiation, 2007 In recent years a novel concept has emerged indicating that the actual role of natural killer (NK) cells is not confined to the destruction of virus-infected cells or tumors. Indeed, different NK subsets exist that display major functional differences in their cytolytic activity, cytokine production and homing capabilities.
MORETTA, ALESSANDRO +4 more
openaire +6 more sources
Adaptive NK cells resist regulatory T cell suppression driven by IL-37 [PDF]
Cancer Immunology Research, 2018 Cross-talk between NK cells and Tregs, mediated by IL37 binding its receptor, altered expression of TIM3 and PD-1 on canonical, but not adaptive, NK cells.
D. Sarhan +12 more
semanticscholar +3 more sources
Differential IL-18 Dependence of Canonical and Adaptive NK Cells for Antibody Dependent Responses to P. falciparum [PDF]
Frontiers in Immunology, 2020 Human adaptive natural killer (NK) cells have diminished reliance on accessory cytokines for their activation whilst being efficiently activated by infected host cells in conjunction with pathogen specific antibodies.
Samuel Sherratt +4 more
doaj +2 more sources
Adaptive NK cell response to human cytomegalovirus: Facts and open issues.
Seminars in Immunology, 2022 Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system. These include the differentiation and persistent expansion of a mature NK cell subset which displays a characteristic phenotypic and functional profile hallmarked by ...
M. López-Botet +4 more
semanticscholar +5 more sources
Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Respiratory diseases are leading causes of death worldwide. However, the local immune cell composition in the human lung and individual outliers within the population still remain largely undescribed.
Demi Brownlie +11 more
semanticscholar +2 more sources
Tissue-specific determinants of the adaptive NK cell response
The Journal of Immunology, 2023 Natural killer (NK) cells are circulating innate lymphocytes that are poised to respond rapidly upon encounter with cancer or virally-infected cells as well as proinflammatory cytokines.
Adriana M. Mujal +6 more
semanticscholar +2 more sources
Adaptive NK cell reconstitution is associated with better clinical outcomes. [PDF]
JCI Insight, 2019 BACKGROUND Human cytomegalovirus (CMV) reactivation is a common occurrence early after transplant and is associated with heterogeneous NK cell subset expansion.
Frank Cichocki +10 more
semanticscholar +3 more sources