Results 11 to 20 of about 103,353 (290)
Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells. [PDF]
Immunohorizons, 2022 Abstract NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of “Ag-specific” NK cells, potentially limiting the diversity of the NK cell response ...
Jensen IJ +3 more
europepmc +8 more sources
Redefining Memory: Building the Case for Adaptive NK Cells. [PDF]
J Virol, 2017 ABSTRACTClassically, natural killer (NK) cells have been defined by nonspecific innate killing of virus-infected and tumor cells. However, burgeoning evidence suggests that the functional repertoire of NK cells is far more diverse than has been previously appreciated, thus raising the possibility that there may be unexpected functional specialization ...
Paust S, Blish CA, Reeves RK.
europepmc +6 more sources
Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37. [PDF]
Cancer Immunol Res, 2018 Abstract Natural killer (NK) cells are capable of fighting viral infections and cancer. However, these responses are inhibited by immune suppressor cells in the tumor microenvironment. Tumor progression promotes the recruitment and generation of intratumoral regulatory T cells (Treg), associated with a poor prognosis in cancer ...
Sarhan D +12 more
europepmc +6 more sources
The Memories of NK Cells: Innate-Adaptive Immune Intrinsic Crosstalk [PDF]
Journal of Immunology Research, 2016 Although NK cells are considered part of the innate immune system, a series of evidences has demonstrated that they possess characteristics typical of the adaptive immune system. These NK adaptive features, in particular their memory-like functions, are discussed from an ontogenetic and evolutionary point of view.
GABRIELLI, SARA +8 more
openaire +8 more sources
FcRγ Gene Editing Reprograms Conventional NK Cells to Display Key Features of Adaptive Human NK Cells [PDF]
iScience, 2020 Summary: Adaptive human natural killer (NK) cells display significantly enhanced responsiveness to a broad-range of antibody-bound targets through the engagement of CD16 compared to conventional NK cells, yet direct reactivity against tumor targets is ...
Weiru Liu +5 more
doaj +3 more sources
NK cells at the interface between innate and adaptive immunity [PDF]
Cell Death & Differentiation, 2007 In recent years a novel concept has emerged indicating that the actual role of natural killer (NK) cells is not confined to the destruction of virus-infected cells or tumors. Indeed, different NK subsets exist that display major functional differences in their cytolytic activity, cytokine production and homing capabilities.
MORETTA, ALESSANDRO +4 more
openaire +7 more sources
Innatus immunis: Evolving paradigm of adaptive NK cells. [PDF]
J Exp Med, 2022 The mechanisms that govern the development of adaptive-like NK cells are elusive. Shemesh et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220551) report that the development of FcRγ−/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α.
Khalil M, Malarkannan S.
europepmc +3 more sources
Selective Expansion of NKG2C+ Adaptive NK Cells Using K562 Cells Expressing HLA-E. [PDF]
Int J Mol Sci, 2022 Adaptive natural killer (NK) cells expressing self-specific inhibitory killer-cell immunoglobulin-like receptors (KIRs) can be expanded in vivo in response to human cytomegalovirus (HCMV) infection.
Phan MT +11 more
europepmc +2 more sources
NK cells in autoimmune diseases: Linking innate and adaptive immune responses [PDF]
Autoimmunity Reviews, 2018 The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution of genetic and environmental factors is generally recognized. Despite autoimmune conditions are principally due to T and B lymphocytes, NK cells also appear to play a role in the promotion and/or maintenance of altered adaptive immune responses or in peripheral ...
Gianchecchi, Elena +2 more
openaire +3 more sources
NK Cells in HIV-1 Infection: From Basic Science to Vaccine Strategies [PDF]
Frontiers in Immunology, 2018 NK cells play a key role in immune response against HIV infection. These cells can destroy infected cells and contribute to adequate and strong adaptive immune responses, by acting on dendritic, T, B, and even epithelial cells. Increased NK cell activity
Lizdany Flórez-Álvarez +4 more
doaj +2 more sources