Results 41 to 50 of about 5,274 (162)
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: The primary objective of this study was to define the transcriptomes and transcriptional regulatory network required for the development and function of adaptive Natural Killer (NK) cells in donors with latent human cytomegalovirus ...
Mohamed Khalil +2 more
doaj +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings +7 more
wiley +1 more source
Journal of Ageing and Longevity, 2022 Immune cells are thought to be involved in a destructive cycle of sterile cerebral inflammatory responses in neurodegenerative diseases such as Parkinson’s Disease (PD).
David Goldeck +9 more
doaj +1 more source
Multiple Sclerosis and Viruses: « Liaisons Dangereuses »
Reviews in Medical Virology, Volume 36, Issue 6, November 2026.ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina +11 more
wiley +1 more source
Proposed model for DAP12-NKG2C complex assembly.
, 2014 (a), (b), and (c) are three different phases of DAP12-NKG2C complex following the unique assembly principle. The structure in (c) was obtained from our CG study, and then we converted it to an atomistic model for a better view.
Cheng-Dong Li (620106) +6 more
core +1 more source
Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.Schematic overview of NK‐EV isolation strategies from expanded primary human NK cells. Primary human NK cells were isolated from PBMCs and expanded using K562 feeder cells. EV‐containing preparations were then isolated from expanded NK‐cell cultures using two approaches. First, total exosome isolation reagent was used as a precipitation‐based method to
Huy Phuoc Quang Nguyen +9 more
wiley +1 more source
Molecular genetic analyses of human NKG2C (KLRC2) gene deletion
, 2004 Human NKG2A, NKG2C and NKG2E genes are located on 12p13 in the NK gene complex. We recently identified deletion of NKG2C in a Japanese population. This study was performed to identify the breakpoint, and to examine the association of NKG2C deletion with ...
Yabe, T +9 more
core +1 more source
Activating KIRs and NKG2C in viral infections: towards NK cell memory?
Frontiers in Immunology, 2015 Natural Killer cells are important players in the immune defence against viral infections. The contribution of activating Killer Immunoglobulin-like Receptors (KIRs) and CD94/NKG2C in regulating anti-viral responses has recently emerged.
Mariella eDella Chiesa +4 more
doaj +1 more source
Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk Neuroblastoma
Frontiers in Immunology, 2021 Neuroblastoma is the most common extracranial childhood solid tumor. The majority of high-risk neuroblastoma is resistant/refractory to the current high intensity therapy, and the survival of these patients remains poor for the last three decades.
Xao X. Tang +2 more
doaj +1 more source
AT-MD simulation of DAP12-NKG2C-DAP12 trimer.
, 2014 A. Time dependence of backbone RMSD for DAP12-NKG2C-DAP12 trimer of three samples. B. Top and side view of the interaction between the key interfacial residues in DAP12-NKG2C-DAP12 complex in PDB structure: 2L35 (b1, b2) and in our DPPC bilayer system ...
Cheng-Dong Li (620106) +6 more
core +1 more source