Results 41 to 50 of about 4,280 (166)

Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.

PLoS Pathogens, 2018
Natural killer (NK) cells classically typify the nonspecific effector arm of the innate immune system, but have recently been shown to possess memory-like properties against multiple viral infections, most notably CMV.
Daniel R Ram, Cordelia Manickam, Brady Hueber, Hannah L Itell, Sallie R Permar, Valerie Varner, R Keith Reeves   +6 more
doaj   +1 more source

Deciphering the biology of NKG2C+ natural killer cells

Oncotarget, 2015
The classic division of the immune system into an innate and an adaptive branch has been one of the dominant paradigms for immunologists shaping both questions and interpretations in the field for many years. This traditional concept has been challenged recently and the once clear boundaries are beginning to blur.
openaire   +2 more sources

Increased early activation of CD56dimCD16dim/- natural killer cells in immunological non-responders correlates with CD4+ T-cell recovery

Chinese Medical Journal, 2020
. Background. Natural killer (NK) cells play a critical role in suppressing human immunodeficiency virus-1 (HIV-1) infection, but knowledge on whether and how NK cells affect immune reconstitution in HIV-1-infected individuals who receive antiretroviral ...
Qiu-Yue Zhang, Xin Zhang, Bin Su, Li-Feng Liu, Xiao-Dong Yang, Bin Tang, Huan Xia, Ping Ma, Tong Zhang, Hao Wu, Peng Lyu   +10 more
doaj   +1 more source

Reduced expansion of CD94/NKG2C⁺ NK cells in chronic lymphocytic leukemia and CLL‐like monoclonal B‐cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions

International Journal of Laboratory Hematology, 2021
AbstractIntroductionDysregulated NK cell‐mediated immune responses contribute to tumor evasion in chronic lymphocytic leukemia (CLL), although the NK cell compartment in CLL‐like monoclonal B‐cell lymphocytosis (MBL) is poorly understood. In healthy individuals, human cytomegalovirus (HCMV) induces the expansion of NK cells expressing high levels of ...
Anna Puiggros, Gonzalo Blanco, Aura Muntasell, María Rodríguez‐Rivera, Lara Nonell, Mireia Altadill, Eulàlia Puigdecanet, Magdalena Arnal, Xavier Calvo, Eva Gimeno, Eugènia Abella, Pau Abrisqueta, Francesc Bosch, José Yélamos, Ana Ferrer, Miguel López‐Botet, Blanca Espinet   +16 more
openaire   +3 more sources

267 Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: The primary objective of this study was to define the transcriptomes and transcriptional regulatory network required for the development and function of adaptive Natural Killer (NK) cells in donors with latent human cytomegalovirus ...
Mohamed Khalil, Scott Terhune, Subramaniam Malarkannan   +2 more
doaj   +1 more source

Enrichment of Cytomegalovirus-induced NKG2C+ Natural Killer Cells in the Lung Allograft

Transplantation, 2019
Background. In lung transplant recipients, immunosuppressive medications result in impaired antiviral immunity and a propensity for cytomegalovirus (CMV) reactivation within the lung allograft. Natural killer (NK) cells play a key role in immunity to CMV, with an increase in the proportion
Christopher M, Harpur, Sanda, Stankovic, Abbie, Kanagarajah, Jacqueline M L, Widjaja, Bronwyn J, Levvey, Yvonne, Cristiano, Greg I, Snell, Andrew G, Brooks, Glen P, Westall, Lucy C, Sullivan   +9 more
openaire   +3 more sources

NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease [PDF]

Journal of Leukocyte Biology, 2010
ABSTRACTThe CD94/NKG2 complex is expressed on T and NK lymphocytes. CD94 molecules covalently associate to activating or inhibitory NKG2 molecules, and their expression finely tunes cell responses. Human γδ T cells express several NKRs. Expression of these receptors is confined to the cytolytic Vδ2 subset, which coexpresses the FcγRIII CD16 and CD45RA ...
D. F. Angelini, R. Zambello, GALANDRINI, Ricciarda, A. Diamantini, R. Placido, Federica Micucci, F. Poccia, G. Semenzato, G. Borsellino, SANTONI, Angela, L. Battistini   +10 more
openaire   +4 more sources

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, Volume 178, Issue 4, Page 685-703, August 2026.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

Higher Frequencies of T-Cells Expressing NK-Cell Markers and Chemokine Receptors in Parkinson’s Disease

Journal of Ageing and Longevity, 2022
Immune cells are thought to be involved in a destructive cycle of sterile cerebral inflammatory responses in neurodegenerative diseases such as Parkinson’s Disease (PD).
David Goldeck, Claudia Schulte, Marcia Cristina Teixeira dos Santos, Dieter Scheller, Lilly Öttinger, Graham Pawelec, Christian Deuschle, Daniela Berg, Andre Nogueira da Costa, Walter Maetzler   +9 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source