Results 51 to 60 of about 4,280 (166)
Clinical &Translational Immunology, Volume 15, Issue 7, 2026.This study demonstrates that high IL‐10 levels during cytokine release syndrome significantly delay natural killer (NK)‐cell recovery after CD19 CAR‐T cell therapy, increasing viral infection risks. Mechanistically, IL‐10 impairs NK‐cell recovery by promoting apoptosis and ferroptosis, suggesting that targeting IL‐10 or employing anti‐inflammatory ...
Xindi Wang +9 more
wiley +1 more source
Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk Neuroblastoma
Frontiers in Immunology, 2021 Neuroblastoma is the most common extracranial childhood solid tumor. The majority of high-risk neuroblastoma is resistant/refractory to the current high intensity therapy, and the survival of these patients remains poor for the last three decades.
Xao X. Tang +2 more
doaj +1 more source
Cellular Heterogeneity During Arterial Aging
Aging Cell, Volume 25, Issue 7, July 2026.Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu +3 more
wiley +1 more source
The Potential Role of Expression of HLA‐E and HLA‐G in Organ Xenotransplantation
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT Xenotransplantation offers a promising solution to the shortage of human organs for transplantation but requires overcoming numerous immune responses—particularly those mediated by the innate immune system through natural killer (NK) cells and macrophages.
Jeffrey K. Sumbo +4 more
wiley +1 more source
NKG2C Deletion Is a Risk Factor for Human Cytomegalovirus Viremia and Disease After Lung Transplantation [PDF]
The Journal of Infectious Diseases, 2017 Human cytomegalovirus (HCMV) replication is limited by HCMV-specific natural killer (NK) cell response. Distinct genetic polymorphisms, which are potentially involved in antiviral NK cell response, have been described. Here, the association between polymorphisms at IgG1 genetic marker 3/17, FcγRIIIα/CD16a 158V/F, NKG2Cwt/del, CD226/rs727088, and ...
Hannes, Vietzen +4 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin +14 more
wiley +1 more source
Adaptive Features of Natural Killer Cells in Multiple Sclerosis
Frontiers in Immunology, 2019 Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile.
Antía Moreira +14 more
doaj +1 more source
Deletion of the Natural Killer Cell Receptor NKG2C Encoding KLR2C Gene and Kidney Transplant Outcome
Frontiers in Immunology, 2022 Natural killer (NK) cells may contribute to antibody-mediated rejection (ABMR) of renal allografts. The role of distinct NK cell subsets in this specific context, such as NK cells expressing the activating receptor NKG2C, is unknown. Our aim was to investigate whether KLRC2 gene deletion variants which determine NKG2C expression affect the ...
Hannes Vietzen +14 more
openaire +4 more sources
Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes
Advanced Science, Volume 13, Issue 31, 4 June 2026.This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang +8 more
wiley +1 more source
Increased proliferative response of highly differentiated CD57+NKG2C+NK cells expressing NKG2A
Медицинская иммунологияDuring infection with cytomegalovirus (HCMV), the content of so-called adaptive NK cells with the CD57+NKG2C+ phenotype increases in the peripheral blood, capable of exhibiting specialized functional activity aimed at controlling the infection upon ...
N. A. Alekseeva +2 more
doaj +1 more source