Results 51 to 60 of about 5,274 (162)

Cytomegalovirus-Infected Primary Endothelial Cells Trigger NKG2C+ Natural Killer Cells

, 2016
International audienceAmong innate cells, natural killer (NK) cells play a crucial role in the defense against cytomegalovirus (CMV). In some individuals, CMV infection induces the expansion of NKG2C+ NK cells that persist after control of the infection.
Retière, Christelle, Djaoud, Zakia, Mehlal, Souad, Bressollette, Céline, Gérard, Nathalie, Gavlovsky, Pierre-Jean, Riou, Raphaëlle, Gagne, Katia, Charreau, Béatrice   +8 more
core   +1 more source

CD49a expression defines a metabolically robust, cytokine‐biased liver NK cell subset in rhesus macaques during lentivirus infection

Immunology &Cell Biology, Volume 104, Issue 7, Page 656-666, August 2026.
Liver‐resident NK cells (CD49a+ NK cells) in rhesus macaques display distinct activating receptor and metabolic markers enhanced phenotype compared with hepatic NK cell subsets (CD49a−) in the liver. These cells exhibit heightened cytokine polyfunctionality with restrained cytotoxic responses upon mitogen stimulation in comparison with CD49a− NK cell ...
Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam   +4 more
wiley   +1 more source

Characterisation of a human herpesvirus 6 variant A 'amplicon' and replication modulation by U94-Rep 'latency gene'.

, 2002
The human herpesvirus 6 (HHV-6) variant A genome has conserved sequences which are signals for initiating lytic replication (origin, 'ori-lyt') and DNA packaging into the virion (pac2/1).
Turner, Simon, Gompels, Ursula, DiLuca, Dario, TURNER S., DI LUCA, Dario, GOMPELS U.   +5 more
core   +1 more source

Adaptive Features of Natural Killer Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile.
Antía Moreira, Antía Moreira, Antía Moreira, Elisenda Alari-Pahissa, Elvira Munteis, Andrea Vera, Ana Zabalza, Mireia Llop, Noelia Villarrubia, Marcel Costa-García, Roberto Álvarez-Lafuente, Luisa María Villar, Miguel López-Botet, Miguel López-Botet, Jose E. Martínez-Rodríguez   +14 more
doaj   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

NKG2C, HLA‐E and their association with psoriasis [PDF]

, 2013
Natural killer (NK) cell activation is regulated by the integration of signals from inhibitory and activating cell surface receptors. Both NKG2A and NKG2C pair with CD94 to form inhibitory and activating receptors specific for the HLA-E-canonical peptide
Marusina, Alina I, Adamopoulos, Iannis E, Maverakis, Emanual, Duong, Christopher, Patel, Forum   +4 more
core   +1 more source

TM Sequences of DAP12, NKG2C, and their mutants.

, 2014
TM Sequences of DAP12, NKG2C, and their mutants.
Cheng-Dong Li (620106), Peng Wei (46487), Lida Xu (326852), Fu-De Sun (620107), Long Chen (315739), Tianwei Tan (457804), Shi-Zhong Luo (620108)   +6 more
core   +1 more source

Genetic Diversity and Haplotype Architecture of Non‐Classical HLA Class I Genes in the Japanese Population

HLA, Volume 108, Issue 2, August 2026.
ABSTRACT The non‐classical Class I genes (HLA‐E, HLA‐F and HLA‐G) show limited protein‐level diversity; however, full‐length analyses that include regulatory and noncoding regions have not been sufficiently performed in East Asian populations. We designed new primers for long‐range PCR and conducted PacBio SMRT sequencing to generate full‐length gene ...
Ikue Ito‐Naito, Seik‐Soon Khor, Tetsuya Sato, Shunichi Wakabayashi, Daisuke Kinoshita, Naoya Kubo, Yosuke Omae, Katsushi Tokunaga, Hiroshi Hayashi   +8 more
wiley   +1 more source

NKG2C+CD57+ Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8+ T Cell Evolution towards Senescence

Journal of Immunology Research, 2016
Objective. Measuring NKG2C+CD57+ natural killer (NK) cell expansion to investigate NK responses against human cytomegalovirus (HCMV) and assessing relationships with adaptive immunity against HCMV. Methods.
John Heath, Nicholas Newhook, Emilie Comeau, Maureen Gallant, Neva Fudge, Michael Grant   +5 more
doaj   +1 more source

Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.

PLoS ONE, 2011
Human natural killer (NK) cell differentiation, characterized by a loss of NKG2A in parallel with the acquisition of NKG2C, KIRs, and CD57 is stimulated by a number of virus infections, including infection with human cytomegalovirus (CMV), hantavirus ...
Niklas K Björkström, Alexandra Svensson, Karl-Johan Malmberg, Kristina Eriksson, Hans-Gustaf Ljunggren   +4 more
doaj   +1 more source