Results 71 to 80 of about 5,274 (162)

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Potential for Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity for Control of Human Cytomegalovirus

Antibodies, 2013
Human cytomegalovirus (HCMV) is an important pathogen that infects the majority of the population worldwide, yet, currently, there is no licensed vaccine.
Rebecca J. Aicheler, Eddie C. Y. Wang, Peter Tomasec, Gavin W. G. Wilkinson, Richard J. Stanton   +4 more
doaj   +1 more source

Development of CAR NK Cell Lines Selectively Targeting Cancer Cells Expressing Membrane Hsp70

MedComm, Volume 7, Issue 5, May 2026.
This work presents a novel CAR NK cell platform targeting membrane‐bound Hsp70, a tumor‐specific antigen broadly expressed on solid tumors but not on normal cells. Computational modeling confirmed strong binding between the CAR construct and the Hsp70‐derived TKD peptide.
Khouloud Hachani, Mina Yazdi, Charlotte Carcopino, Fatemeh Khademi Moghadam, Micholas Dean Smith, Anskar Trill, Marcel P. Trefny, Morteza Hasanzadeh Kafshgari, Cosima C. Hoch, Abdallah Gaballa, Bayan Alkotub, Jennifer Altomonte, A. Graham Pockley, Ernst Wagner, Barbara Wollenberg, Sebastian Kobold, Gabriele Multhoff, Ali Bashiri Dezfouli   +17 more
wiley   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients – PART 1: Risk Factors, Clinical Impact and Immune Response

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan, Emily Blyth, Gaurav Sutrave, Michelle K. Yong, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Lauren Stern   +7 more
wiley   +1 more source

Latent cytomegalovirus infection enhances anti-tumour cytotoxicity through accumulation of NKG2C+ NK cells in healthy humans

, 2016
Item does not contain fulltextCytomegalovirus (CMV) infection markedly expands NKG2C+/NKG2A- NK cells, which are potent killers of infected cells expressing human leucocyte antigen (HLA)-E.
Balneger, N., Sekine, T., Agha, N., Kunz, H., Pistillo, M, Agha, N, O'Connor, D.P., Bollard, C.M., Bigley, A B, Simpson, R.J., Simpson, R J, Bigley, A.B., Balneger, N, Shah, N., Rezvani, K, Sekine, T, Rezvani, K., O\u27Connor, D P, Shah, N, Pistillo, M., Kunz, H, Bollard, C M   +21 more
core   +1 more source

HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?

Frontiers in Immunology, 2018
Adaptive Natural Killer (NK) cells, a heterogenous subpopulation of human NK cells with a unique phenotypic and functional signature, became arguably one of the central areas of interest in the field.
Alexander Rölle, Alexander Rölle, Dirk Jäger, Dirk Jäger, Frank Momburg   +4 more
doaj   +1 more source

Anti-CD94-induced expansion of highly functional adaptive NKG2C+NKG2A−CD57+selfKIR+ NK cells from CMV-seropositive healthy donors

Human Natural Killer (NK) cells are innate lymphocytes, short-living and providing rapid responses against viral infections and tumors. Adaptive NK cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection, characterized by the ...
Della Chiesa M., Carlomagno S., Falco M., Caruana I., Cantoni C., Muccio L., Vitale M., Giordano C., Sivori S.   +8 more
core   +1 more source

Characterization of cytomegalovirus-induced adaptive NK cells and the role of CD94/NKG2C receptor [PDF]

, 2017
Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartment in some individuals, promoting the development of a mature NK cell subset, hallmarked by high expression levels of the CD94/NKG2C activating ...
Pupuleku, Aldi, 1985-, Pupuleku, Aldi
core  

The evolution of minimum distance between side chain beads of Asp1 (or residues Asp1 mutated to) and Lys (or residue Lys mutated to) (black), Asp2 (or residues Asp2 mutated to) and Lys (or residue Lys mutated to) (red) of all four mutants of the trimer: DAP12-NKG2C-D50L, DAP12-NKG2C-D50N, DAP12-K52L-DAP12, and T54A-NKG2C-T54A.

, 2014
The evolution of minimum distance between side chain beads of Asp1 (or residues Asp1 mutated to) and Lys (or residue Lys mutated to) (black), Asp2 (or residues Asp2 mutated to) and Lys (or residue Lys mutated to) (red) of all four mutants of the trimer ...
Cheng-Dong Li (620106), Peng Wei (46487), Lida Xu (326852), Fu-De Sun (620107), Long Chen (315739), Tianwei Tan (457804), Shi-Zhong Luo (620108)   +6 more
core   +1 more source

NKG2C⁺ NK cells express IFN-γ in response to NKG2C engagement.

, 2014
(A and B) Viable CD3− CD56dim NK cells were FACS sorted and stimulated by cross-linking of NKG2C and/or 2B4 for 16 hours. Analysis of intracellular IFN-γ expression was performed by FC after gating on CD56dim CD57+ NKG2A− sKIR+ cells from HCMV+ donors ...
Quirin Hammer (646128), Alf Hamann (8747), Hyun-Dong Chang (24045), Jun Dong (43792), Merlin Luetke-Eversloh (646127), Chiara Romagnani (646131), Pawel Durek (646129), Matthias Pink (405163), Jörn Walter (37094), Karl Nordström (3530954), Gilles Gasparoni (646130)   +10 more
core   +1 more source