Results 91 to 100 of about 5,274 (162)

The Impact of Cytomegalovirus Infection on Natural Killer and CD8+ T Cell Phenotype in Multiple Sclerosis

Biology
Multiple sclerosis (MS) is a debilitating neurological disease that has been classified as an immune-mediated attack on myelin, the protective sheath of nerves. Some aspects of its pathogenesis are still unclear; nevertheless, it is generally established
Valentina Perri, Maria Antonella Zingaropoli, Patrizia Pasculli, Federica Ciccone, Matteo Tartaglia, Viola Baione, Leonardo Malimpensa, Gina Ferrazzano, Claudio Maria Mastroianni, Antonella Conte, Maria Rosa Ciardi   +10 more
doaj   +1 more source

CNS1 demethylation occurs independent of CD57/sKIR expression and is stably imprinted in NKG2C^hi NK cells.

, 2014
(A–C) Phenotype and methylation status of the CNS1 was analyzed in ex vivo NKG2Chi NK cell expansions from representative HCMV+ donors (n = 4), as described in Figure 1.
Quirin Hammer (646128), Alf Hamann (8747), Hyun-Dong Chang (24045), Jun Dong (43792), Merlin Luetke-Eversloh (646127), Chiara Romagnani (646131), Pawel Durek (646129), Matthias Pink (405163), Jörn Walter (37094), Karl Nordström (3530954), Gilles Gasparoni (646130)   +10 more
core   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source

Persistence of NKG2C⁺CD57⁺ NK cells in CHIKV-infected patients with high viral loads.

, 2016
Results are grouped according to 1) type of infection: DENV-2, CHIKV or co-infected by CHIKV and DENV-2 (CHIKV/DENV-2), and non-infected Gabonese healthy controls (NI) and 2) date of sample collection after onset of symptoms: early acute (EA; day (D)0-D3)
Illich Mombo (184018), Mélanie Caron (184012), Dieudonné Nkoghé (2552347), Eric Leroy (264004), Vincent Vieillard (186338), Nadia Wauquier (204255), Patrice Debré (186335), Caroline Petitdemange (204252), Hervé Devilliers (2552344), Hans Yssel (233157)   +9 more
core   +1 more source

Cytotoxic NKG2C+ CD4 T cells target oligodenfrocytes in Multiple Sclerosis

, 2013
The mechanisms whereby immune cells infiltrating the central nervous system in multiple sclerosis (MS) contribute to tissue injury remain to be defined. CD4 T cells are implicated as key mediators of the deleterious inflammation observed in MS.
Zaguia, Fatma
core  

Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection

, 2010
Background: The HIV-1-induced expansion of highly dysfunctional natural killer (NK) cell subsets represents a strategy to evade NK cell antiviral functions.
E. Brunetta, E. Marcenaro, D. Mavilio, L. Bozzo, M. Fogli, S. Varchetta, A. Moretta, K.L. Hudspeth   +7 more
core   +1 more source

NKG2C+ memory-like NK cells contribute to the control of HIV viremia during primary infection: Optiprim-ANRS 147

, 2017
International audienceNatural-killer (NK) cells are important immune effectors during a viral infection. Latent CMV infection is widely spread and was demonstrated to shape the NK cell repertoire through the NKG2C receptor.
Antoine Chéret, Ghislain Bidaut, Gondois-Rey, Françoise, Camille Lécuroux, Véronique Avettand-Fenoël, Moretta, Alessandro, Samuel Granjeaud, Daniel Olive, Alessandro Moretta, Cécile Goujard, Michaela Müller-Trutwin, Mickaël Ploquin, Laurence Meyer, Müller-Trutwin, Michaela, Avettand-Fénoêl, Véronique, Ploquin, Mickaël, Meyer, Laurence, Mallet, Françoise, Françoise Mallet, Chéret, Antoine, Lecuroux, Camille, Bidaut, Ghislain, Rouzioux, Christine, Gilles Pialoux, Goujard, Cecile, Françoise Gondois-Rey, Pialoux, Gilles, Olive, Daniel, Christine Rouzioux, Granjeaud, Samuel   +29 more
core   +1 more source

Expanded NKG2C^hi NK cells display complete demethylation of the IFNG CNS1.

, 2014
Analysis of surface marker expression and methylation status of the IFNG promoter and CNS1 was analyzed as described in Figure 1 in ex vivo NK cell subsets derived from representative HCMV− (n = 2) (A) or HCMV+ (n = 4) donors (B and C), without (B) or ...
Quirin Hammer (646128), Alf Hamann (8747), Hyun-Dong Chang (24045), Jun Dong (43792), Merlin Luetke-Eversloh (646127), Chiara Romagnani (646131), Pawel Durek (646129), Matthias Pink (405163), Jörn Walter (37094), Karl Nordström (3530954), Gilles Gasparoni (646130)   +10 more
core   +1 more source

Polycytotoxic T cells mediate antimicrobial activity against intracellular Mycobacterium tuberculosis

Infection and Immunity
Protection against infections with intracellular bacteria requires the interaction of macrophages and T-lymphocytes, including CD8+ T cells. Recently, the expression of natural killer cell receptors NKG2A and NKG2C was introduced as markers of CD8+ T ...
Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger   +7 more
doaj   +1 more source

Single-cell analysis unravels the role of NK cells and monocytes in the control of SARS-CoV-2 breakthrough infections in vaccinated individuals

Human Vaccines & Immunotherapeutics
Analyzing the antiviral response of natural killer (NK) cells and monocytes is essential to understanding vaccine protection in an immunized population facing SARS-CoV-2 variant breakthrough infections (BTIs).
Huiwen Zheng, Jing Li, Xin Zhang, Yun Liao, Heng Li, Xin Zhao, Zihan Zhang, Jingjing Wang, Li Yu, Dandan Li, Heng Zhao, Haijing Shi, Longding Liu   +12 more
doaj   +1 more source