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Implications of NKG2A in immunity and immune-mediated diseases

Frontiers in Immunology, 2022
In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8+ T cells. It form heterodimer receptors with CD94, and targets the peptide-presenting human leukocyte antigen-E (HLA-E) molecules.
Zhaochen Ning, Xiaotong Wang, Ning Zhaochen   +2 more
exaly   +5 more sources

CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer

Frontiers in Immunology, 2020
Background: NKG2A is an inhibitory receptor of both T cells and natural killer (NK) cells. Persistent activation promotes T cells and NK cells to express NKG2A and results in the progression of chronic infection and cancer.
Pin Wu, Lijian Huang, Lufeng Zhao
exaly   +3 more sources

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions

Cell Reports, 2021
Summary: Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer.
, Domenico Mavilio, Lorenzo Bello
exaly   +3 more sources

Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells [PDF]

Molecular Therapy: Oncology
Natural killer (NK) cells have the intrinsic ability to kill cancer cells and are thus targeted in immunotherapy. Anti-CD19 CAR NK cells have shown efficacy in clinical studies in treating B cell malignancies; however, the full cytotoxic capacities of ...
Juliane Mietz, Lukas Egli, Meike Misiune, Arianna Picozzi, Nicolò Coianiz, Danielle Thompson, Marianna Ponzo, Alisson Charmey, Beat Bornhauser, Chiara F. Magnani, Christian Münz, Obinna Chijioke   +11 more
doaj   +2 more sources

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

Frontiers in Immunology, 2018
Natural killer (NK) cell-based immunotherapy is a promising therapy for cancer patients. Inhibitory killer immunoglobulin-like receptors (KIRs) and NKG2A are required for NK cell licensing, but can also inhibit NK cell effector function.
Marcel Tilanus, Gérard Bos, Femke Ehlers   +2 more
exaly   +3 more sources

The inhibitory receptor NKG2A is expressed on T-cells during BKPyVANephropathy [PDF]

Frontiers in Immunology
IntroductionBKPyV-associated nephropathy (BKPyVAN) is a major complication in kidney transplantation. An exhaustion of BKPyV-specific T-cells but not T-cells against other viruses is observed, suggesting a mechanism specifically mediated by BKPyV ...
Karen Bargiel, Karen Bargiel, Christophe Desterke, Christophe Desterke, Manon Dekeyser, Manon Dekeyser, Manon Dekeyser, Marion Rabant, Marion Rabant, Lea Dutour, Amelie Grosjean, Arthur Tenenhaus, Amelia Vernochet, Amelia Vernochet, Florence Herr, Florence Herr, Antoine Durrbach, Antoine Durrbach, Antoine Durrbach   +18 more
doaj   +2 more sources

Longitudinal Dynamics of NK-Cell Regulatory Signaling and IVIG Response in Kawasaki Disease [PDF]

Children
Background and Objectives: Kawasaki disease (KD) is an acute systemic vasculitis in children, and approximately 10–20% of patients develop resistance to intravenous immunoglobulin (IVIG), which is associated with an increased risk of coronary artery ...
Yeonju Kim, Insu Choi, Kyung Soon Choi, In Seok Jeong, Hwa Jin Cho   +4 more
doaj   +2 more sources

Improvement of NK Cell Cytotoxicity in Reconstituting NK Cells after Allogeneic Stem Cell Transplantation by Blocking NKG2A Checkpoint [PDF]

Middle East Journal of Cancer, 2023
Background: One cause of tumor relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the alteration of the graft-versus-tumor effect of early reconstituting natural killer (NK) cells due to overexpression of the NKG2A inhibitory
Mohammed Taha, Cyril Fauriat
doaj   +1 more source

KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

Cell Reports, 2023
Summary: Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A.
Seong Jin Choi, June-Young Koh, Min-Seok Rha, In-Ho Seo, Hoyoung Lee, Seongju Jeong, Su-Hyung Park, Eui-Cheol Shin   +7 more
doaj   +1 more source

Comprehensive Pan-Cancer Analysis Reveals the Potential Biological, Immunological, and Prognostic Value of NKG2A

Analytical Cellular Pathology, 2023
Background. NKG2A (KLRC1) belongs to the NKG2 family, which has been shown to affect the activity of natural killer (NK) cells and CD8T cells. However, a comprehensive biological analysis and exploration of NKG2A in different cancers is lacking and this ...
Yao Rong, Yongfeng Wang, Mingzheng Tang, Guiqian Zhang, Yuan Yuan, Fengyuan Dong, Zhihang Wu, Guorong Ma, Songhua Liu, Xiashuang Zhao, Hui Cai   +10 more
doaj   +1 more source