Results 1 to 10 of about 10,258 (173)

Implications of NKG2A in immunity and immune-mediated diseases

Frontiers in Immunology, 2022
In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8+ T cells. It form heterodimer receptors with CD94, and targets the peptide-presenting human leukocyte antigen-E (HLA-E) molecules.
Xiaotong Wang, Xiaotong Wang, Huabao Xiong, Huabao Xiong, Zhaochen Ning, Zhaochen Ning   +5 more
exaly   +5 more sources

NKG2A-HLA-E axis contributes to an immunosuppressive checkpoint network in hepatocellular carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background The immunosuppressive tumor microenvironment in hepatocellular carcinoma (HCC) limits the efficacy of current immunotherapies. The interplay between the emerging inhibitory receptor NKG2A and its activating counterpart NKG2C, both binding HLA ...
Yan Li, Yingzi Huang, Patrick P C Boor, Dave Sprengers, Zhu Li, Wei Qin, Xiaoying Wu, Gang Deng, Songlin Peng, Yisen Tang, Xiaomei Zhuang, Wanhua Feng, Guoying Zhou, Di Tang, Yuanyu Lin, Zubing Chen, Ze Song, Sonja I Buschow   +17 more
doaj   +2 more sources

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions

Cell Reports, 2021
Summary: Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer.
Domenico Mavilio, Lorenzo Bello
exaly   +3 more sources

Preclinical characterization of S095029, a novel clinical-stage Fc-attenuated NKG2A-blocking antibody for cancer immunotherapy [PDF]

Frontiers in Oncology
Natural killer group 2 family of receptor A (NKG2A) and its ligand human leukocyte antigen-E (HLA-E) are increasingly recognised as an important immune checkpoint restraining lymphocyte populations involved in cancer immunity.
Maria Carlsen Melander, Franziska Uhlenbrock, Anne Worsaae, Randi W. Hansen, Julien Mafille, Daniel Andersen, Samantha Knockaert, Wendy Philippon, Nikolaj Dietrich, Michael M. Grandal, Agnete Marie Granau, Chris D. Madsen, Alba Diaz-Herrero, Alba Diaz-Herrero, Fabien Melchiore, Johanna Verneau, Soraia Cerqueira, Matthieu Bouaziz, Mathieu Boucher, Tania Køllgaard, Jamila Elhmouzi-Younes, Niels Jørgen Skartved, Pierre Tonnerre, Céline Lefebvre, Véronique Blanc, Trine Lindsted, Camilla Frölich, Bruno Laugel   +27 more
doaj   +2 more sources

NKG2A–HLA-E and TIM3–galectin 9 pathways promote immune inhibition and represent therapeutic vulnerabilities in pancreatic ductal adenocarcinoma [PDF]

Cancer Immunology, Immunotherapy
Background The roles of NKG2A–HLA-E and TIM3–galectin 9 immune checkpoint pathways in pancreatic ductal adenocarcinoma (PDAC) progression remain incompletely characterized.
Yuanyu Lin, Wanhua Feng, Yan Li, Yisen Tang, Xiaomei Zhuang, Yingzi Huang, Juping Xie, Kai Liu, Youwen Fan, Yajun Tang, Dong Li, Ziming He, Yuxiong Qiu, Junzong Chen, Jie Xu, Zheng Yang, Linxiang Lan, Di Tang, Gang Deng, Guoying Zhou   +19 more
doaj   +2 more sources

Co-editing of NKG2A and FAS increases long-term cytotoxic capacity and persistence of CAR NK cells [PDF]

Molecular Therapy: Oncology
Natural killer (NK) cells have the intrinsic ability to kill cancer cells and are thus targeted in immunotherapy. Anti-CD19 CAR NK cells have shown efficacy in clinical studies in treating B cell malignancies; however, the full cytotoxic capacities of ...
Juliane Mietz, Lukas Egli, Meike Misiune, Arianna Picozzi, Nicolò Coianiz, Danielle Thompson, Marianna Ponzo, Alisson Charmey, Beat Bornhauser, Chiara F. Magnani, Christian Münz, Obinna Chijioke   +11 more
doaj   +2 more sources

Longitudinal Dynamics of NK-Cell Regulatory Signaling and IVIG Response in Kawasaki Disease [PDF]

Children
Background and Objectives: Kawasaki disease (KD) is an acute systemic vasculitis in children, and approximately 10–20% of patients develop resistance to intravenous immunoglobulin (IVIG), which is associated with an increased risk of coronary artery ...
Yeonju Kim, Insu Choi, Kyung Soon Choi, In Seok Jeong, Hwa Jin Cho   +4 more
doaj   +2 more sources

The inhibitory receptor NKG2A is expressed on T-cells during BKPyVANephropathy [PDF]

Frontiers in Immunology
IntroductionBKPyV-associated nephropathy (BKPyVAN) is a major complication in kidney transplantation. An exhaustion of BKPyV-specific T-cells but not T-cells against other viruses is observed, suggesting a mechanism specifically mediated by BKPyV ...
Karen Bargiel, Karen Bargiel, Christophe Desterke, Christophe Desterke, Manon Dekeyser, Manon Dekeyser, Manon Dekeyser, Marion Rabant, Marion Rabant, Lea Dutour, Amelie Grosjean, Arthur Tenenhaus, Amelia Vernochet, Amelia Vernochet, Florence Herr, Florence Herr, Antoine Durrbach, Antoine Durrbach, Antoine Durrbach   +18 more
doaj   +2 more sources

Improvement of NK Cell Cytotoxicity in Reconstituting NK Cells after Allogeneic Stem Cell Transplantation by Blocking NKG2A Checkpoint [PDF]

Middle East Journal of Cancer, 2023
Background: One cause of tumor relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the alteration of the graft-versus-tumor effect of early reconstituting natural killer (NK) cells due to overexpression of the NKG2A inhibitory
Mohammed Taha, Cyril Fauriat
doaj   +1 more source

CD8+ T Cells Form the Predominant Subset of NKG2A+ Cells in Human Lung Cancer

Frontiers in Immunology, 2020
Background: NKG2A is an inhibitory receptor of both T cells and natural killer (NK) cells. Persistent activation promotes T cells and NK cells to express NKG2A and results in the progression of chronic infection and cancer.
Yongyuan Chen, Yongyuan Chen, Zhongwei Xin, Zhongwei Xin, Lijian Huang, Lufeng Zhao, Shijie Wang, Jiwei Cheng, Pin Wu, Pin Wu, Pin Wu, Ying Chai   +11 more
doaj   +1 more source