Results 11 to 20 of about 15,525 (208)
NKG2A inhibits TH2 cell effector function
BMC Pulmonary Medicine, 2007 Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar +4 more
doaj +3 more sources
Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
Haematologica, 2016 Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri +10 more
doaj +3 more sources
High Metabolic Function and Resilience of NKG2A-Educated NK Cells [PDF]
Frontiers in Immunology, 2020 Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors.
Andrew J. Highton +9 more
doaj +4 more sources
The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells
Scientific Reports, 2023 Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with target cells ...
Meike Kaulfuss +5 more
doaj +5 more sources
Differential expression of inhibitory receptor NKG2A distinguishes disease‐specific exhausted CD8+ T cells [PDF]
MedComm, 2022 Exhausted CD8+ T (Tex) cells are caused by persistent antigenic stimulation during chronic viral infection or tumorigenesis. Tex cells upregulate and sustain the expressions of multiple immune inhibitory receptors (IRs).
Xiangyu Chen +19 more
doaj +3 more sources
Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans [PDF]
, 2018 Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with a ...
Anderson, J +7 more
core +9 more sources
Monalizumab: inhibiting the novel immune checkpoint NKG2A [PDF]
Journal for ImmunoTherapy of Cancer, 2019 The implementation of immune checkpoint inhibitors to the oncology clinic signified a new era in cancer treatment. After the first indication of melanoma, an increasing list of additional cancer types are now treated with immune system targeting antibodies to PD-1, PD-L1 and CTLA-4, alleviating inhibition signals on T cells.
Hall, T. van +8 more
openaire +5 more sources
Role That Each NKG2A Immunoreceptor Tyrosine-Based Inhibitory Motif Plays in Mediating the Human CD94/NKG2A Inhibitory Signal [PDF]
The Journal of Immunology, 2002 Abstract The human NKG2A chain of the CD94/NKG2A receptor contains two immunoreceptor Tyr-based inhibitory motifs (ITIMs) in its cytoplasmic tail. To determine the relative importance of membrane-distal (residues 6–11) and membrane-proximal (residues 38–43) ITIMs in mediating the inhibitory signal, we made site-directed mutants of NKG2A ...
Juraj, Kabat +3 more
openaire +2 more sources
Analytical Cellular Pathology, 2023 Background. NKG2A (KLRC1) belongs to the NKG2 family, which has been shown to affect the activity of natural killer (NK) cells and CD8T cells. However, a comprehensive biological analysis and exploration of NKG2A in different cancers is lacking and this ...
Yao Rong +10 more
doaj +1 more source
Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus [PDF]
Rheumatology, 2013 To characterize a novel anti-NKG2A autoantibody detected in a patient with SLE during a severe flare, and in a cross-sectional study investigate the occurrence of such autoantibodies in patients with SLE and primary SS (pSS).Serum or IgG from patients with SLE, pSS and healthy volunteers were assayed for blocking of anti-NKG2A or HLA-E binding to ...
Niklas, Hagberg +5 more
openaire +5 more sources