Results 11 to 20 of about 9,856 (174)

NKG2A inhibits TH2 cell effector function in vitro [PDF]

BMC Pulmonary Medicine, 2007
Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar, Freishtat Robert J, Nazemzadeh Maryam, Nagaraju Kanneboyina, Hoffman Eric P   +4 more
doaj   +3 more sources

High Metabolic Function and Resilience of NKG2A-Educated NK Cells [PDF]

Frontiers in Immunology, 2020
Natural killer (NK) cells are an important component of the innate immune system for the control of intracellular pathogens and cancer cells. NK cells demonstrate heterogeneous expression of inhibitory surface receptors.
Andrew J. Highton, Björn-Philipp Diercks, Franziska Möckl, Gloria Martrus, Jürgen Sauter, Alexander H. Schmidt, Madeleine J. Bunders, Christian Körner, Andreas H. Guse, Marcus Altfeld   +9 more
doaj   +3 more sources

NKG2A, a New Kid on the Immune Checkpoint Block [PDF]

Cell, 2018
One of the major breakthroughs of cancer immunotherapy has come from blocking immune checkpoint molecules on tumor-reactive T cells. Now, two studies examine targeting of a novel immune checkpoint, NKG2A, that can be expressed on both NK cells and on CD8+ T cells, either combined with a tumor-targeting antibody or with a tumor-specific vaccine.
John B, Haanen, Vincenzo, Cerundolo
openaire   +2 more sources

Monalizumab: inhibiting the novel immune checkpoint NKG2A [PDF]

Journal for ImmunoTherapy of Cancer, 2019
The implementation of immune checkpoint inhibitors to the oncology clinic signified a new era in cancer treatment. After the first indication of melanoma, an increasing list of additional cancer types are now treated with immune system targeting antibodies to PD-1, PD-L1 and CTLA-4, alleviating inhibition signals on T cells.
Hall, T. van, Andre, P., Horowitz, A., Ruan, D.F., Borst, L., Zerbib, R., Narni-Mancinelli, E., Burg, S.H. van der, Vivier, E.   +8 more
openaire   +5 more sources

Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis. [PDF]

PLoS ONE, 2012
To investigate the role of inhibitory natural killer receptors (iNKRs) in inflammatory bowel disease (IBD), we analyzed the expression of NKG2A, one of the iNKRs, on T cells in a mouse colitis model and human IBD.
Takehiko Katsurada, Waka Kobayashi, Utano Tomaru, Tomohisa Baba, Shigeru Furukawa, Akihiro Ishizu, Kazuyoshi Takeda, Naoya Sakamoto, Masahiro Asaka, Hiroshi Takeda, Masanori Kasahara   +10 more
doaj   +1 more source

Role That Each NKG2A Immunoreceptor Tyrosine-Based Inhibitory Motif Plays in Mediating the Human CD94/NKG2A Inhibitory Signal [PDF]

The Journal of Immunology, 2002
Abstract The human NKG2A chain of the CD94/NKG2A receptor contains two immunoreceptor Tyr-based inhibitory motifs (ITIMs) in its cytoplasmic tail. To determine the relative importance of membrane-distal (residues 6–11) and membrane-proximal (residues 38–43) ITIMs in mediating the inhibitory signal, we made site-directed mutants of NKG2A ...
Juraj, Kabat, Francisco, Borrego, Andrew, Brooks, John E, Coligan   +3 more
openaire   +2 more sources

Cell Therapy Using Anti-NKG2A Pretreated Natural Killer Cells in Patients with Hepatocellular Carcinoma [PDF]

Advanced Pharmaceutical Bulletin
Purpose: The activities and functions of natural killer (NK) cells are regulated by a limited repertoire of activating and inhibitory receptors. Thus, we provided a study of inhibition of the NKG2A using monoclonal antibodies (mAbs), and as a primary ...
Shirin Tavakoli, Maryam Samareh-Salavati, Shahrokh Abdolahi, Javad Verdi, Iman Seyhoun, Nasim Vousooghi, Mohammad Vaezi, Afshin Ghaderi, Ardeshir Ghavamzadeh, Maryam Barkhordar, Mohammad Ahmadvand   +10 more
doaj   +1 more source

The NKG2A–HLA-E Axis as a Novel Checkpoint in the Tumor Microenvironment [PDF]

Clinical Cancer Research, 2020
AbstractThe success of checkpoint blockade therapy revolutionized cancer treatment. However, we need to increase the fraction of responding patients and overcome acquired resistance to these therapies. Recently, the inhibitory receptor NKG2A received attention as a new kid on the block of immune checkpoints.
Borst, L., Burg, S.H. van der, Hall, T. van   +2 more
openaire   +3 more sources

Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma

BMC Research Notes, 2021
Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue ...
Ridwan Dwi Saputro, Hanggoro Tri Rinonce, Yayuk Iramawasita, Muhammad Rasyid Ridho, Maria Fransiska Pudjohartono, Sumadi Lukman Anwar, Kunto Setiaji, Teguh Aryandono   +7 more
doaj   +1 more source

NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells

Journal for ImmunoTherapy of Cancer, 2023
Background The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 (encoding NKG2D) that are central to regulation of NK cell function.
Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wöhr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B Thorén   +10 more
doaj   +1 more source