Results 21 to 30 of about 15,525 (208)

NKG2A, a New Kid on the Immune Checkpoint Block [PDF]

Cell, 2018
One of the major breakthroughs of cancer immunotherapy has come from blocking immune checkpoint molecules on tumor-reactive T cells. Now, two studies examine targeting of a novel immune checkpoint, NKG2A, that can be expressed on both NK cells and on CD8+ T cells, either combined with a tumor-targeting antibody or with a tumor-specific vaccine.
John B, Haanen, Vincenzo, Cerundolo
openaire   +2 more sources

Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis. [PDF]

PLoS ONE, 2012
To investigate the role of inhibitory natural killer receptors (iNKRs) in inflammatory bowel disease (IBD), we analyzed the expression of NKG2A, one of the iNKRs, on T cells in a mouse colitis model and human IBD.
Takehiko Katsurada, Waka Kobayashi, Utano Tomaru, Tomohisa Baba, Shigeru Furukawa, Akihiro Ishizu, Kazuyoshi Takeda, Naoya Sakamoto, Masahiro Asaka, Hiroshi Takeda, Masanori Kasahara   +10 more
doaj   +1 more source

TCR Specificity Dictates CD94/NKG2A Expression by Human CTL [PDF]

Immunity, 2002
Activating and inhibitory CD94/NKG2 receptors regulate CTL responses by altering TCR signaling, thus modifying antigen activation thresholds set during thymic selection. To determine whether their expression was linked to TCR specificity, we examined the TCR repertoire of oligoclonal CTL expansions found in human blood and tissues.
Jabri, Bana, Selby, Jeanette M, Negulescu, Horia, Lee, Leanne, Roberts, Arthur I, Beavis, Andrew, Lopez-Botet, Miguel, Ebert, Ellen C, Winchester, Robert J   +8 more
openaire   +2 more sources

Cell Therapy Using Anti-NKG2A Pretreated Natural Killer Cells in Patients with Hepatocellular Carcinoma [PDF]

Advanced Pharmaceutical Bulletin
Purpose: The activities and functions of natural killer (NK) cells are regulated by a limited repertoire of activating and inhibitory receptors. Thus, we provided a study of inhibition of the NKG2A using monoclonal antibodies (mAbs), and as a primary ...
Shirin Tavakoli, Maryam Samareh-Salavati, Shahrokh Abdolahi, Javad Verdi, Iman Seyhoun, Nasim Vousooghi, Mohammad Vaezi, Afshin Ghaderi, Ardeshir Ghavamzadeh, Maryam Barkhordar, Mohammad Ahmadvand   +10 more
doaj   +1 more source

Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]

, 2012
Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Chi, X., Hou, J., Hu, X., Jin, Q., Lv, J., Niu, J., Pan, Y., Sun, H., Tian, Z., Tu, Z., Xiao, W., Xu, D., Yan, H.   +12 more
core   +3 more sources

NKG2A Inhibits Invariant NKT Cell Activation in Hepatic Injury [PDF]

The Journal of Immunology, 2009
Abstract Activation of invariant NKT (iNKT) cells in the liver is generally regarded as the critical step for Con A-induced hepatitis, and the role of NK cell receptors for iNKT cell activation is still controversial. In this study we show that blockade of the NKG2A-mediated inhibitory signal with antagonistic anti-NKG2A/C/E mAb (20d5 ...
Kawamura, Toshihiko, Takeda, Kazuyoshi, Kaneda, Hiroshi, Matsumoto, Hiroaki, Hayakawa, Yoshihiro, Raulet, David H., Ikarashi, Yoshinori, Kronenberg, Mitchell, Yagita, Hideo, Kinoshita, Katsuyuki, Abo, Toru, Okumura, Ko, Smyth, Mark J.   +12 more
openaire   +3 more sources

Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis [PDF]

, 2018
Background. Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non-classical MHC class I molecules that specifically interact with the natural killer receptors NKG2A ...
Angioni, Mm, Cauli, A, Congia, M, Dessole, G, Fiorillo, Mt, Floris, A, Mascia, E, Mathieu, A., Paladini, F, Piga, M, Pinna, S, Sorrentino, R, Tedeschi, V   +12 more
core   +1 more source

Increased NKG2A+CD8+ T-cell exhaustion in patients with adenomyosis

Mucosal Immunology, 2023
Immune dysregulation has long been proposed to be associated with adenomyosis, but the underlying mediators and mechanisms remain largely unexplored. Here, we used flow cytometry to investigate the alterations in immune cell subsets in adenomyotic uteri and analyze the phenotype and function of abnormal immune cells.
Wei, Liu, Shuman, Sheng, Chendi, Zhu, Changzhong, Li, Yonghui, Zou, Chunrun, Yang, Zi-Jiang, Chen, Fei, Wang, Xue, Jiao   +8 more
openaire   +2 more sources

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment

Frontiers in Immunology, 2018
Natural killer (NK) cell-based immunotherapy is a promising therapy for cancer patients. Inhibitory killer immunoglobulin-like receptors (KIRs) and NKG2A are required for NK cell licensing, but can also inhibit NK cell effector function.
Niken M. Mahaweni, Niken M. Mahaweni, Niken M. Mahaweni, Femke A. I. Ehlers, Femke A. I. Ehlers, Femke A. I. Ehlers, Subhashis Sarkar, Subhashis Sarkar, Johanna W. H. Janssen, Marcel G. J. Tilanus, Marcel G. J. Tilanus, Gerard M. J. Bos, Gerard M. J. Bos, Lotte Wieten, Lotte Wieten   +14 more
doaj   +1 more source

Expression of CD226 is associated to but not required for NK cell education [PDF]

, 2017
DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory
Bernhardt, Günter, Brodin, Petter, Chambers, Benedict J, Colonna, Marco, Gilfillan, Susan, Höglund, Petter, Kadri, Nadir, Kärre, Klas, Snäll, Johanna, Wagner, Arnika K   +9 more
core   +2 more sources