Results 21 to 30 of about 10,258 (173)
Role That Each NKG2A Immunoreceptor Tyrosine-Based Inhibitory Motif Plays in Mediating the Human CD94/NKG2A Inhibitory Signal [PDF]
The Journal of Immunology, 2002 Abstract The human NKG2A chain of the CD94/NKG2A receptor contains two immunoreceptor Tyr-based inhibitory motifs (ITIMs) in its cytoplasmic tail. To determine the relative importance of membrane-distal (residues 6–11) and membrane-proximal (residues 38–43) ITIMs in mediating the inhibitory signal, we made site-directed mutants of NKG2A ...
Juraj, Kabat +3 more
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BMC Research Notes, 2021 Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue ...
Ridwan Dwi Saputro +7 more
doaj +1 more source
Engineered iNKNKG2A KO cells possess HLA-E specific anti-tumor activity [PDF]
Jichu yixue yu linchuangObjective To target at the NKG2A-HLA-E inhibitory axis, a pluripotent stem cell(iPSC)-derived genetically engineered natural killer cells(NK cells) with NKG2A knockout (NKG2A KO-iNK) were prepared and then their tumor-killing efficacy was evaluated in ...
QIAO Wenhua, XU Yi, DONG Peng, HE Wei, CHEN Hui, ZHANG Jianmin
doaj +1 more source
Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer
OncoImmunology, 2022 Recently, the inhibitory CD94/NKG2A receptor has joined the group of immune checkpoints (ICs) and its expression has been documented in NK cells and CD8+ T lymphocytes in several cancers and some infectious diseases.
Kathleen Ducoin +13 more
doaj +1 more source
NKG2A is a NK cell exhaustion checkpoint for HCV persistence [PDF]
Nature Communications, 2019 AbstractExhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined.
Chao Zhang +14 more
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Journal for ImmunoTherapy of Cancer, 2023 Background The natural killer (NK) complex (NKC) harbors multiple genes such as KLRC1 (encoding NKG2A) and KLRK1 (encoding NKG2D) that are central to regulation of NK cell function.
Brwa Ali Hussein +10 more
doaj +1 more source
Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus [PDF]
Rheumatology, 2013 To characterize a novel anti-NKG2A autoantibody detected in a patient with SLE during a severe flare, and in a cross-sectional study investigate the occurrence of such autoantibodies in patients with SLE and primary SS (pSS).Serum or IgG from patients with SLE, pSS and healthy volunteers were assayed for blocking of anti-NKG2A or HLA-E binding to ...
Niklas, Hagberg +5 more
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Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections
iScience, 2021 Summary: Some viruses have established an equilibrium with their host. African green monkeys (AGM) display persistent high viral replication in the blood and intestine during Simian immunodeficiency virus (SIV) infection but resolve systemic inflammation
Nicolas Huot +11 more
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Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
Haematologica, 2016 Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri +10 more
doaj +1 more source
The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells
Scientific Reports, 2023 Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with target cells ...
Meike Kaulfuss +5 more
doaj +1 more source