Results 21 to 30 of about 9,856 (174)

Engineered iNKNKG2A KO cells possess HLA-E specific anti-tumor activity [PDF]

Jichu yixue yu linchuang
Objective To target at the NKG2A-HLA-E inhibitory axis, a pluripotent stem cell(iPSC)-derived genetically engineered natural killer cells(NK cells) with NKG2A knockout (NKG2A KO-iNK) were prepared and then their tumor-killing efficacy was evaluated in ...
QIAO Wenhua, XU Yi, DONG Peng, HE Wei, CHEN Hui, ZHANG Jianmin
doaj   +1 more source

Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer

OncoImmunology, 2022
Recently, the inhibitory CD94/NKG2A receptor has joined the group of immune checkpoints (ICs) and its expression has been documented in NK cells and CD8+ T lymphocytes in several cancers and some infectious diseases.
Kathleen Ducoin, Romain Oger, Linda Bilonda Mutala, Cécile Deleine, Nicolas Jouand, Juliette Desfrançois, Juliette Podevin, Emilie Duchalais, Jonathan Cruard, Houssem Benlalam, Nathalie Labarrière, Céline Bossard, Anne Jarry, Nadine Gervois-Segain   +13 more
doaj   +1 more source

NKG2A is a NK cell exhaustion checkpoint for HCV persistence [PDF]

Nature Communications, 2019
AbstractExhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined.
Chao Zhang, Xiao-mei Wang, Shu-ran Li, Trix Twelkmeyer, Wei-hong Wang, Sheng-yuan Zhang, Shu-feng Wang, Ji-zheng Chen, Xia Jin, Yu-zhang Wu, Xin-wen Chen, Sheng-dian Wang, Jun-qi Niu, Hai-rong Chen, Hong Tang   +14 more
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The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells

Scientific Reports, 2023
Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has established regulatory functions in the direct interaction with target cells ...
Meike Kaulfuss, Juliane Mietz, Astrid Fabri, Johannes vom Berg, Christian Münz, Obinna Chijioke   +5 more
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Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections

iScience, 2021
Summary: Some viruses have established an equilibrium with their host. African green monkeys (AGM) display persistent high viral replication in the blood and intestine during Simian immunodeficiency virus (SIV) infection but resolve systemic inflammation
Nicolas Huot, Philippe Rascle, Nicolas Tchitchek, Benedikt Wimmer, Caroline Passaes, Vanessa Contreras, Delphine Desjardins, Christiane Stahl-Hennig, Roger Le Grand, Asier Saez-Cirion, Beatrice Jacquelin, Michaela Müller-Trutwin   +11 more
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Anti-NKG2A autoantibodies in a patient with systemic lupus erythematosus [PDF]

Rheumatology, 2013
To characterize a novel anti-NKG2A autoantibody detected in a patient with SLE during a severe flare, and in a cross-sectional study investigate the occurrence of such autoantibodies in patients with SLE and primary SS (pSS).Serum or IgG from patients with SLE, pSS and healthy volunteers were assayed for blocking of anti-NKG2A or HLA-E binding to ...
Niklas, Hagberg, Jakob, Theorell, Maija-Leena, Eloranta, Veronique, Pascal, Yenan T, Bryceson, Lars, Rönnblom   +5 more
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NKG2A and CD56 Are Coexpressed on Activated TH2 but Not TH1 Lymphocytes [PDF]

Human Immunology, 2005
NKG2A is commonly expressed on cytotoxic cells but has been found on activated T helper (TH) cells. In identifying novel markers differentiating between TH1 and TH2 lymphocytes, we focused on NKG2A expression. TH1 and TH2 cells were negatively isolated from healthy volunteers for microarray analysis and reverse transcription polymerase chain reaction ...
Robert J, Freishtat, Lindsay W, Mitchell, Svetlana D, Ghimbovschi, Samuel B, Meyers, Eric P, Hoffman   +4 more
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Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

Haematologica, 2016
Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri, Elena Urbani, Pascale André, Antonella Mancusi, Antonella Tosti, Fabiana Topini, Mathieu Bléry, Lucia Animobono, François Romagné, Nicolai Wagtmann, Andrea Velardi   +10 more
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NKG2A Inhibits Invariant NKT Cell Activation in Hepatic Injury [PDF]

The Journal of Immunology, 2009
Abstract Activation of invariant NKT (iNKT) cells in the liver is generally regarded as the critical step for Con A-induced hepatitis, and the role of NK cell receptors for iNKT cell activation is still controversial. In this study we show that blockade of the NKG2A-mediated inhibitory signal with antagonistic anti-NKG2A/C/E mAb (20d5)
Kawamura, Toshihiko, Takeda, Kazuyoshi, Kaneda, Hiroshi, Matsumoto, Hiroaki, Hayakawa, Yoshihiro, Raulet, David H., Ikarashi, Yoshinori, Kronenberg, Mitchell, Yagita, Hideo, Kinoshita, Katsuyuki, Abo, Toru, Okumura, Ko, Smyth, Mark J.   +12 more
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Increased NKG2A+CD8+ T-cell exhaustion in patients with adenomyosis

Mucosal Immunology, 2023
Immune dysregulation has long been proposed to be associated with adenomyosis, but the underlying mediators and mechanisms remain largely unexplored. Here, we used flow cytometry to investigate the alterations in immune cell subsets in adenomyotic uteri and analyze the phenotype and function of abnormal immune cells.
Wei, Liu, Shuman, Sheng, Chendi, Zhu, Changzhong, Li, Yonghui, Zou, Chunrun, Yang, Zi-Jiang, Chen, Fei, Wang, Xue, Jiao   +8 more
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