Results 41 to 50 of about 9,856 (174)

Innate Immune Cells in Non‐Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses

Cancer Innovation, Volume 5, Issue 4, August 2026.
Innate immune cells (IICs) are not only as first‐line defenders or simple auxiliaries to adaptive immunity, but also as decisive regulators of non‐small cell lung cancer progression and treatment outcomes. ABSTRACT As a leading cause of cancer‐related morbidity and mortality worldwide, non‐small cell lung cancer (NSCLC) is profoundly influenced by ...
Jiaxin Liu, Jie Jia, Chong Wang, Zongru Zhou, Zhuoyu Cheng, Ziyi Zhang, Xueyi Jiang, Ziyu Huang, Chunyan Li   +8 more
wiley   +1 more source

IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells

Nature Communications
Blockade of NKG2A/HLA-E interaction is a promising strategy to unleash the anti-tumor response. Yet the role of NKG2A+ CD8 T cells in the anti-tumor response and the regulation of NKG2A expression on human tumor-infiltrating T cells are still poorly ...
Olivier Fesneau, Kimberly A. Samson, Wesley Rosales, Bretton Jones, Tarsem Moudgil, Bernard A. Fox, Venkatesh Rajamanickam, Thomas Duhen   +7 more
doaj   +1 more source

NKG2C+NKG2A− Natural Killer Cells are Associated with a Lower Viral Set Point and may Predict Disease Progression in Individuals with Primary HIV Infection

Frontiers in Immunology, 2017
Natural killer (NK) cells are the first line of defense against pathogens of the immune system and also play an important role in resistance against HIV. The activating receptor NKG2C and the inhibitory receptor NKG2A co-modulate the function of NK cells
Meichen Ma, Meichen Ma, Zhuo Wang, Zhuo Wang, Xi Chen, Xi Chen, Anfu Tao, Anfu Tao, Lei He, Lei He, Shuai Fu, Shuai Fu, Zining Zhang, Zining Zhang, Yajing Fu, Yajing Fu, Chenxi Guo, Chenxi Guo, Jing Liu, Jing Liu, Xiaoxu Han, Xiaoxu Han, Junjie Xu, Junjie Xu, Zhenxing Chu, Zhenxing Chu, Haibo Ding, Haibo Ding, Hong Shang, Hong Shang, Yongjun Jiang, Yongjun Jiang   +31 more
doaj   +1 more source

Hepatitis B e Antigen Induces NKG2A+ Natural Killer Cell Dysfunction via Regulatory T Cell-Derived Interleukin 10 in Chronic Hepatitis B Virus Infection

Frontiers in Cell and Developmental Biology, 2020
Although persistent hepatitis B virus (HBV) infection is associated with natural killer (NK) cell dysfunction, it remains obscure whether HBV viral antigens are responsible for NK cell dysfunction in patients with chronic hepatitis B (CHB) infection.
Qingqing Ma, Xiaoyu Dong, Siyu Liu, Tao Zhong, Dandan Sun, Lu Zong, Changcheng Zhao, Qiong Lu, Min Zhang, Yufeng Gao, Ying Ye, Jun Cheng, Yuanhong Xu, Meijuan Zheng   +13 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Natural killer NKG2A and NKG2D in patients with colorectal cancer

Journal of Gastrointestinal Oncology, 2019
Natural-killer group 2 (NKG2), a characteristic receptor of natural killer (NK) cell family, assumes a vital role in modulating NK cytotoxic function. We aimed to detect mRNA expression of both NKG2A and NKG2D in serum NK cells obtained from colorectal cancer (CRC) patients.We enrolled 36 patients with newly diagnosed CRC, as well as 15 group matched ...
Ghada R, Meckawy, Ahmed M, Mohamed, Wafaa K, Zaki, Mona A, Khattab, Mariam M, Amin, Mai A, ElDeeb, Marwa R, El-Najjar, Nesma A, Safwat   +7 more
openaire   +2 more sources

Temporal Association Between COVID‐19 Vaccination and HBsAg Loss in Chronic Hepatitis B Infection: An Interrupted Time Series Analysis

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 517-526, August 2026.
In 59,946 chronic hepatitis B patients followed over 23 years, COVID‐19 vaccination rollout was temporally associated with a 56% increase in HBsAg loss rates (peak 1.27 per 100 person‐years in 2022), followed by gradual waning. Negative control outcomes showed no similar pattern, supporting biological specificity. ABSTRACT Background and Aims Hepatitis
Jonggi Choi, Allison Carroll, Vy H. Nguyen, Megan Michta, Xuan Q. Zhang, Young‐Suk Lim, Raymond T. Chung   +6 more
wiley   +1 more source

Differential expression of inhibitory receptor NKG2A distinguishes disease‐specific exhausted CD8+ T cells

MedComm, 2022
Exhausted CD8+ T (Tex) cells are caused by persistent antigenic stimulation during chronic viral infection or tumorigenesis. Tex cells upregulate and sustain the expressions of multiple immune inhibitory receptors (IRs).
Xiangyu Chen, Yao Lin, Shuai Yue, Yang Yang, Xinxin Wang, Zhiwei Pan, Xiaofan Yang, Leiqiong Gao, Jing Zhou, Zhirong Li, Li Hu, Jianfang Tang, Qing Wu, Yifei Wang, Qin Tian, Yaxing Hao, Lifan Xu, Bo Zhu, Qizhao Huang, Lilin Ye   +19 more
doaj   +1 more source

CD49a expression defines a metabolically robust, cytokine‐biased liver NK cell subset in rhesus macaques during lentivirus infection

Immunology &Cell Biology, Volume 104, Issue 7, Page 656-666, August 2026.
Liver‐resident NK cells (CD49a+ NK cells) in rhesus macaques display distinct activating receptor and metabolic markers enhanced phenotype compared with hepatic NK cell subsets (CD49a−) in the liver. These cells exhibit heightened cytokine polyfunctionality with restrained cytotoxic responses upon mitogen stimulation in comparison with CD49a− NK cell ...
Andrew Hudson, Melissa Xin Yu Wong, Michael Verdolin, R Keith Reeves, Cordelia Manickam   +4 more
wiley   +1 more source