Results 41 to 50 of about 15,525 (208)

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases [PDF]

, 2014
The Ly49E NK receptor is a unique inhibitory receptor, presenting with a high degree of conservation among mouse strains and expression on both NK cells and intraepithelial-localised T cells.
Devisscher, Lindsey, Filtjens, Jessica, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Taghon, Tom, Taveirne, Sylvie, Van Acker, Aline, Van Ammel, Els, Van Welden, Sophie, Vandekerckhove, Bart, Vanhees, Mandy   +11 more
core   +11 more sources

Altered distribution of mucosal NK cells during HIV infection. [PDF]

, 2012
The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s ...
Alter, G, Berger, CT, Carrington, M, Deeks, SG, Diefenbach, T, Dugast, A-S, Estes, JD, Ghebremichael, M, Hunt, PW, Kwon, D, Liu, Q, Martin, JN, Sciaranghella, G, Sips, M   +13 more
core   +2 more sources

Altered CD94/NKG2A and perforin expression reduce the cytotoxic activity in malignant pleural effusions [PDF]

, 2011
CD94/NKG2A is an inhibitory receptor expressed by NK cells and cytotoxic lymphocytes and, upon activation by HLA-E, downregulates the cytolytic activities of these cells thus representing a tumour immune escape mechanism.
Bellia, V., Di Sano, C., Ferraro, M., Gjomarkaj, M., Olivieri, D., Pace, E., Santagata, R., Spatafora, M., Tipa, A.   +8 more
core   +1 more source

Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection. [PDF]

PLoS ONE, 2014
Virus infection triggers a CD8(+) T cell response that aids in virus clearance, but also expresses effector functions that may result in tissue injury.
Kenneth H Ely, Mitsuo Matsuoka, Matthew P DeBerge, Jessica A Ruby, Jun Liu, Mark J Schneider, Yan Wang, Young S Hahn, Richard I Enelow   +8 more
doaj   +1 more source

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia [PDF]

, 2017
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack.
Aurelius, J., Bernson, E., Brune, M., Foà, R., Hallner, A., Hellstrand, K., Kiffin, R., Martner, A., Rydström, A., Sander, F. E., Thorén, F. B., Werlenius, O., Wilsson, O.   +12 more
core   +1 more source

Setting traps for NKG2A gives NK cell immunotherapy a fighting chance [PDF]

Journal of Clinical Investigation, 2019
The equilibrium of signaling through activating and inhibitory receptors dictates whether a given NK cell will execute cellular cytotoxicity. In this issue of the JCI, Kamiya et al. describe a novel approach to efficiently inhibiting surface expression of the inhibitory receptor CD94/NK group 2 member A (NKG2A) through retention of the protein in the ...
Frank, Cichocki, Jeffrey S, Miller
openaire   +2 more sources

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Alonso, Corona, Arcos, María José, Bañas, Helena, Bergua, Juan M., Casas-Avilés, Ignacio, Durán, Esther, Hassouneh, Fakhri, López-Sejas, Nelson, Pera Rojas, Alejandra, Solana, Rafael, Sánchez-Correa, Beatriz, Tarazona, Raquel, Valhondo, Isabel   +12 more
core   +1 more source

Association of NKG2A with treatment for chronic hepatitis C virus infection [PDF]

Clinical and Experimental Immunology, 2010
SummaryNatural killer (NK) cells are critical to the immune response to viral infections. Their functions are controlled by receptors for major histocompatibility complex (MHC) class I, including NKG2A and killer-cell immunoglobulin-like receptors (KIR).
Harrison, R.J., Ettorre, A., Little, A-M., Khakoo, S.I.   +3 more
openaire   +3 more sources

Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies

EMBO Molecular Medicine, 2023
AbstractNK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice. We found that intratumoral delivery of NK cells attains significant therapeutic effects only if co‐injected with anti‐NKG2A and ...
Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez‐Gregorio, Saray Garasa, Carlos Luri‐Rey, Sandra Hervas‐Stubbs, Noelia Casares, Edurne Elizalde, Gabriel Gomis, Assunta Cirella, Pedro Berraondo, Alvaro Teijeira, Maite Alvarez   +13 more
openaire   +3 more sources

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles. [PDF]

, 2016
KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important
Bao, Ju, Bari, Rafijul, Leung, Wing, Li, Ying, Thapa, Rajoo, Zheng, Jie   +5 more
core   +1 more source