Results 61 to 70 of about 10,258 (173)

The Unfolded Protein Response as a Modulator of Cancer‐Immune Cell Communication in the Tumour Microenvironment

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT The tumour microenvironment (TME) comprises a dynamic network of structural, cellular, and signalling components that interact to influence tumour development. Immune cells play a key role in recognizing and eliminating cancer cells through detection of tumour‐derived membrane and secreted proteins processed in the endoplasmic reticulum (ER ...
Yew Hwang Chee, Matthieu Moncan, Eileen Reidy, Adrienne M. Gorman, Afshin Samali   +4 more
wiley   +1 more source

Comparative two-dimensional NKG2A/CD94 cell membrane chromatography for targeted screening immune checkpoint inhibitors

Journal of Pharmaceutical Analysis
The natural killer (NK) group 2 member A/C-type lectin domain family 4 member A (NKG2A/CD94) heterodimeric receptor is commonly recognized as a crucial immune checkpoint in NK cells.
Yanting Li, Yanqiu Gu, Weiyue Zhang, Tianhua Li, Chun Chen, Chengliang Wang, Yifeng Chai, Xueqin Ma, Xiaofei Chen   +8 more
doaj   +1 more source

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.

PLoS Pathogens, 2016
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK) cells (iNKRs) tolerize mature NK cell responses toward normal cells.
Zachary B Davis, Andrew Cogswell, Hamish Scott, Amanda Mertsching, Julie Boucau, Daniel Wambua, Sylvie Le Gall, Vicente Planelles, Kerry S Campbell, Edward Barker   +9 more
doaj   +1 more source

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
wiley   +1 more source

Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Signal Transduction and Targeted Therapy
Acute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exhaustion in AML
Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao   +14 more
doaj   +1 more source

Downregulation of CD94/NKG2A inhibitory receptors on CD8⁺ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

Retrovirology, 2007
The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8+ T lymphocytes.
Vaira Dolores, Schaaf-Lafontaine Nicole, Leonard Philippe, Frippiat Frédéric, Jacobs Nathalie, Vandamme Arnaud, Rahmouni Souad, Zeddou Mustapha, Boniver Jacques, Moutschen Michel   +9 more
doaj   +1 more source

Parallel processing of T cells and natural killer cells to enhance in vivo CAR T cell activity against blood and solid cancers

Clinical &Translational Immunology, Volume 15, Issue 9, 2026.
Abstract Objectives Despite their anti‐cancer properties, natural killer (NK) cells are discarded during CAR T cell manufacturing. NK cells display promising responses as a cell therapy, exhibiting remarkable safety at high doses. Moreover, NK cells have complementary cytokine profiles and distinct antigen‐recognition pathways to supplement CAR T cell ...
Lachlan J Dobson, Patrick W Marron, Ariana HT Drabble, Thiloma D Liyanage, Kristine C Pe, Clare Y Slaney, Barry D Hock, Alexander D McLellan   +7 more
wiley   +1 more source

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host

Cellular and Molecular Life Sciences
Background Alveolar echinococcosis (AE) is a fatal zoonotic parasitic disease with biological characteristics similar to cancer. Although previous studies have reported immune dysfunction of Natural Killer (NK) cells due to other inhibitory receptors in ...
Ayinuer Aierken, Aili Aierken, Kalibixiati Aimulajiang, Abuduaini Abulizi, Zhongdian Yuan, Chang Liu, Dalong Zhu, Hanyue Zhao, Tuerganaili Aji   +8 more
doaj   +1 more source

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist

Drug Delivery
As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust and sustained ...
Jie Chen, Enhui Ren, Ze Tao, Hongyu Lu, Yunchuan Huang, Jing Li, Yuzhe Chen, Zhuo Chen, Tianshan She, Hao Yang, Hong Zhu, Xiaofeng Lu   +11 more
doaj   +1 more source

Semi‐Mechanistic Modeling of S‐531011, a Humanized Anti‐CCR8 Monoclonal Antibody, for Prediction of CCR8 Receptor Occupancy in Human Tumor Tissues

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Semi‐mechanistic modeling approaches could be useful for optimal dose selection, and one of the approaches is pharmacokinetic (PK)/receptor occupancy (RO) model for monoclonal antibodies. This study aimed to develop a semi‐mechanistic PK/RO model of S‐531011, a humanized monoclonal antibody against human CCR8 and under development for the ...
Daichi Yamaguchi, Wataru Nogami, Yudai Sonoda, Hitomi Morihara, Takayuki Katsube   +4 more
wiley   +1 more source