Results 61 to 70 of about 9,856 (174)

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist

Drug Delivery
As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust and sustained ...
Jie Chen, Enhui Ren, Ze Tao, Hongyu Lu, Yunchuan Huang, Jing Li, Yuzhe Chen, Zhuo Chen, Tianshan She, Hao Yang, Hong Zhu, Xiaofeng Lu   +11 more
doaj   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia

Signal Transduction and Targeted Therapy
Acute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exhaustion in AML
Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao   +14 more
doaj   +1 more source

Comparative two-dimensional NKG2A/CD94 cell membrane chromatography for targeted screening immune checkpoint inhibitors

Journal of Pharmaceutical Analysis
The natural killer (NK) group 2 member A/C-type lectin domain family 4 member A (NKG2A/CD94) heterodimeric receptor is commonly recognized as a crucial immune checkpoint in NK cells.
Yanting Li, Yanqiu Gu, Weiyue Zhang, Tianhua Li, Chun Chen, Chengliang Wang, Yifeng Chai, Xueqin Ma, Xiaofei Chen   +8 more
doaj   +1 more source

EGFR‐Targeting IgG1 Antibody Enhances NK Cell‐Mediated Tumor Killing in KRAS‐Mutant Pancreatic Cancer

MedComm, Volume 7, Issue 7, July 2026.
In KRAS‐mutant pancreatic cancer, persistent downstream signaling can limit the efficacy of EGFR‐targeting mAbs. However, the addition of NK cells enables nimotuzumab to effectively direct a potent antitumor response via antibody‐dependent cellular cytotoxicity (ADCC), overcoming this resistance mechanism.
Ruoxi Xiao, Xiaoxiao Li, Ping Li, Junjin Wang, Xiaoyuan Sun, Chenyang Zhao, Zimin Liu, Ruining Gong, Minghan Ren, Ke Lei, He Ren   +10 more
wiley   +1 more source

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host

Cellular and Molecular Life Sciences
Background Alveolar echinococcosis (AE) is a fatal zoonotic parasitic disease with biological characteristics similar to cancer. Although previous studies have reported immune dysfunction of Natural Killer (NK) cells due to other inhibitory receptors in ...
Ayinuer Aierken, Aili Aierken, Kalibixiati Aimulajiang, Abuduaini Abulizi, Zhongdian Yuan, Chang Liu, Dalong Zhu, Hanyue Zhao, Tuerganaili Aji   +8 more
doaj   +1 more source

The Potential Role of Expression of HLA‐E and HLA‐G in Organ Xenotransplantation

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Xenotransplantation offers a promising solution to the shortage of human organs for transplantation but requires overcoming numerous immune responses—particularly those mediated by the innate immune system through natural killer (NK) cells and macrophages.
Jeffrey K. Sumbo, Xiaowei Hu, Eckhard Wolf, David K. C. Cooper, Leo H. Buhler   +4 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

NKG2A and COVID-19: another brick in the wall [PDF]

Cellular & Molecular Immunology, 2020
Antonioli L., Fornai M., Pellegrini C., Blandizzi C.   +3 more
openaire   +3 more sources

A Novel Prognostic Nomogram Based on TIGIT and NKG2A Can Predict Relapse‐Free Survival of Hepatocellular Carcinoma After Hepatectomy

Cancer Medicine
Background and Objectives Hepatocellular carcinoma (HCC) is a major global health concern, and emerging evidence suggests that TIGIT and NKG2A are potential immune checkpoints with implications for HCC progression.
Junqi Wang, Yuqing Cao, Yu Tian, Chaoliu Dai, Tianqiang Jin, Feng Xu   +5 more
doaj   +1 more source