Results 81 to 90 of about 10,258 (173)

Generation, Characterization, and Preclinical Studies of a Novel NKG2A-Targeted Antibody BRY805 for Cancer Immunotherapy

Antibodies
Immuno-oncology has revolutionized cancer treatment, with NKG2A emerging as a novel target for immunotherapy. The blockade of NKG2A using the immune checkpoint inhibitor (ICI) monalizumab has been shown to enhance the responses of both NK cells and CD8 ...
Yaqiong Zhou, Yiru Wang, Jinfeng Liang, Jing Qian, Zhenhua Wu, Zhangzhao Gao, Jian Qi, Shanshan Zhu, Na Li, Yao Chen, Gang Chen, Lei Nie, Tingting Guo, Haibin Wang   +13 more
doaj   +1 more source

分娩发动前后体内NK细胞、NKT细胞表型分析

Zhongguo shiyan zhenduanxue, 2009
目的研究分娩发动前后蜕膜及外周血中NK细胞、NKT细胞表面NKG2A和NKG2D受体的表达情况,探讨其在产程发动中的作用。方法选取正常孕足月孕妇分为分娩发动经阴道分娩组（以下简称分娩组20例）和分娩未发动行选择性剖宫产术组（以下简称剖宫产组20例）,分离蜕膜及外周血中单个核细胞后采用流式细胞学技术分别检测CD56+细胞、NK细胞、NKT细胞表面NKG2A和NKG2D受体的表达情况。结果外周血单个核细胞中分娩组CD56+NKG2A+细胞构成下降、CD56+NKG2D+细胞构成增加,NK细胞 ...
陈红波, 凌斌, 周颖, 冯定庆, 徐静竹, 黄大雁   +5 more
doaj  

Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56dimNKG2A+ NK cells.

PLoS Pathogens
NK cells could participate in the pathogenesis process of virus infectious diseases through the inhibitory receptor CD94/NKG2A interacting with HLA-E/virus-derived peptide complex.
Manling Xue, Kang Tang, Yusi Zhang, Xiaoyue Xu, Chunmei Zhang, Jiajia Zuo, Fenglan Wang, Xiyue Zhang, Xuyang Zheng, Ran Zhuang, Yun Zhang, Boquan Jin, Ying Ma   +12 more
doaj   +1 more source

CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells

Nature Communications
Chimeric antigen receptor (CAR)-modified natural killer (NK) cells show antileukemic activity against acute myeloid leukemia (AML) in vivo. However, NK cell-mediated tumor killing is often impaired by the interaction between human leukocyte antigen (HLA)-
Tobias Bexte, Nawid Albinger, Ahmad Al Ajami, Philipp Wendel, Leon Buchinger, Alec Gessner, Jamal Alzubi, Vinzenz Särchen, Meike Vogler, Hadeer Mohamed Rasheed, Beate Anahita Jung, Sebastian Wolf, Raj Bhayadia, Thomas Oellerich, Jan-Henning Klusmann, Olaf Penack, Nina Möker, Toni Cathomen, Michael A. Rieger, Katharina Imkeller, Evelyn Ullrich   +20 more
doaj   +1 more source

Donor NKG2A/NKG2C Immunophenotype Influences the GMP-Compliant Manufacturing Potential of NK Cells for Adoptive Immunotherapy. [PDF]

Cancers (Basel)
Meseguer R, Aguilar C, Amat P, Larrea L, Bonora A, Chorão P, Boix F, Piñana JL, Guerrero R, Montesinos P, Vera B, Planelles D, Luis M, Poveda JL, De la Rubia J, Querol S, Arbona C, Guerreiro M, Solano C.   +18 more
europepmc   +1 more source

Adipocyte-derived LTB4 programs human NKG2A⁺ γδ T cells as cytotoxic sentinels at the adipose-tumor interface in breast cancer. [PDF]

J Immunother Cancer
Hu X, Wu D, Jia F, Zhu S, Ke S, Chen D, Zhao J, Li L, Zhang Y, Wang Z, Jin X, Zhu W, Huang F, Chen H, Xing P, Ding J, Meng L, Ding Y, Wang Y, Xu J, Ren G, Chen W, Shao X, Ni C, Yu X, Pang L, Zhang L, Pan J, Pan W, Xu N, Yu Z, Qiu F, Yan J, Huang J.   +33 more
europepmc   +1 more source

Beyond KIR and NKG2A blockade: reprogramming NK-cell immunity in solid tumors. [PDF]

Front Cell Dev Biol
Pastorino C, Falco M, Giordano C, Zarefeizabadi N, Rutigliani M, Carbone A, Clavarezza M, Ortolani F, Nanni L, Della Chiesa M, Sivori S, Carlomagno S.   +11 more
europepmc   +1 more source

Diagnosis of NK-large granular lymphocytic leukemia. [PDF]

Blood Adv
Pastoret C, Lamy T, Roussel M.
europepmc   +1 more source

The role of SDF_1α/CXCR4 axis in non-antibody mediated TRALI in cardiac surgery patients. [PDF]

Intensive Care Med Exp
Vourc'h M, Ferron E, Poulain C, David G, Volteau C, Poschmann J, Braud M, Josien R, Rozec B, Villadangos JA, Retiere C, Asehnoune K.   +11 more
europepmc   +1 more source

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation. [PDF]

Sci Adv
De Silva P, Fitzgerald S, Cazaubiel J, Qian K, Hofree M, Lin JR, Pelletier R, Lopez Leon M, Ho PVM, Takashima Y, Väyrynen JP, Matsuda K, Ugai T, Ford-Roshon D, Bala P, Hacohen N, Ng K, Nowak JA, Ogino S, Sorger PK, Giannakis M.   +20 more
europepmc   +1 more source