Results 81 to 90 of about 15,525 (208)

Membrane microdomains and glycosylation of activating receptors influence natural killer cell regulation [PDF]

, 2010
Natural killer (NK) cells represent the first lymphoid subpopulation in the defense against tumors and viral infection. The activity of NK cells is regulated by the interplay of activating and inhibitory surface receptors.
Margraf-Schönfeld, Stefanie
core   +1 more source

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells.

PLoS Pathogens, 2016
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK) cells (iNKRs) tolerize mature NK cell responses toward normal cells.
Zachary B Davis, Andrew Cogswell, Hamish Scott, Amanda Mertsching, Julie Boucau, Daniel Wambua, Sylvie Le Gall, Vicente Planelles, Kerry S Campbell, Edward Barker   +9 more
doaj   +1 more source

Downregulation of CD94/NKG2A inhibitory receptors on CD8⁺ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts

Retrovirology, 2007
The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8+ T lymphocytes.
Vaira Dolores, Schaaf-Lafontaine Nicole, Leonard Philippe, Frippiat Frédéric, Jacobs Nathalie, Vandamme Arnaud, Rahmouni Souad, Zeddou Mustapha, Boniver Jacques, Moutschen Michel   +9 more
doaj   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females?

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn, Nuria Alvarez‐Sanchez, Lawrence Steinman   +2 more
wiley   +1 more source

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor [PDF]

The Journal of Experimental Medicine, 1997
CD94 is a C-type lectin expressed by natural killer (NK) cells and a subset of T cells. Blocking studies using anti-CD94 mAbs have suggested that it is a receptor for human leukocyte antigen class I molecules. CD94 has recently been shown to be a 26-kD protein covalently associated with an unidentified 43-kD protein(s).
Brooks, AG, Posch, PE, Scorzelli, CJ, Borrego, F, Coligan, JE   +4 more
openaire   +3 more sources

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

T Cell Responses during Acute Respiratory Virus Infection [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Braciale, Thomas J., Kim, Taeg S., Legge, Kevin L., Sun, Jie   +3 more
core   +1 more source

NKG2A and CD56 Are Coexpressed on Activated TH2 but Not TH1 Lymphocytes [PDF]

Human Immunology, 2005
NKG2A is commonly expressed on cytotoxic cells but has been found on activated T helper (TH) cells. In identifying novel markers differentiating between TH1 and TH2 lymphocytes, we focused on NKG2A expression. TH1 and TH2 cells were negatively isolated from healthy volunteers for microarray analysis and reverse transcription polymerase chain reaction ...
Robert J, Freishtat, Lindsay W, Mitchell, Svetlana D, Ghimbovschi, Samuel B, Meyers, Eric P, Hoffman   +4 more
openaire   +2 more sources

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist

Drug Delivery
As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust and sustained ...
Jie Chen, Enhui Ren, Ze Tao, Hongyu Lu, Yunchuan Huang, Jing Li, Yuzhe Chen, Zhuo Chen, Tianshan She, Hao Yang, Hong Zhu, Xiaofeng Lu   +11 more
doaj   +1 more source

EBV Genome Variations and Association With Diseases

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin, Jingtong Liang, Qiuting Zhang, Qinyao Huang, Xinyu Zhang, Miao Xu   +5 more
wiley   +1 more source