Results 91 to 100 of about 15,525 (208)
Journal of Pharmaceutical AnalysisThe natural killer (NK) group 2 member A/C-type lectin domain family 4 member A (NKG2A/CD94) heterodimeric receptor is commonly recognized as a crucial immune checkpoint in NK cells.
Yanting Li +8 more
doaj +1 more source
Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer
MedComm, Volume 7, Issue 4, April 2026.This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin +10 more
wiley +1 more source
Signal Transduction and Targeted TherapyAcute myeloid leukemia (AML) relapse is associated with poor prognosis. While natural killer (NK) cell therapy can induce leukemia remission, infused NK cells are prone to exhaustion. Elucidating the molecular mechanisms driving NK cell exhaustion in AML
Juan Xie +14 more
doaj +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.Single‐cell profiling of PBMCs from centenarians, their offspring, and elderly controls revealed distinct myeloid‐to‐effector immune cell communication programs. General aging was characterized by SASP‐enriched signaling associated with immunosenescence, whereas healthy aging showed positive immune regulatory signaling associated with enhanced ...
Liwei Qiu +7 more
wiley +1 more source
Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT [PDF]
, 2014 Interactions between natural killer (NK) cells and dendritic cells (DC) aid DC maturation and promote T cell responses. Here, we have analysed the response of human NK cells to tumor cells and we identify a pathway by which NK-DC interactions occur ...
Andrew V. Benest +8 more
core +2 more sources
Cell Proliferation, Volume 59, Issue 4, April 2026.Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen +5 more
wiley +1 more source
Frequency and role of NKp46 and NKG2A in hepatitis B virus infection
PLOS ONE, 2017 Natural Killer (NK) cells are involved in the control of viral infection. However, the role of NK cells in chronic hepatitis B (CHB) remains unclear. This study investigated the frequencies and roles of NK cells in CHB, with a focus on activating receptor NKp46 and inhibitory receptor NKG2A.Peripheral blood lymphocytes were obtained from 71 CHB ...
Teppei Yoshioka +12 more
openaire +4 more sources
NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection [PDF]
, 2017 Background Chronic HBV infection can be divided into 4 distinct clinical phases: immune tolerant, immune active, inactive carrier, and HBeAg-negative hepatitis.
Boonstra, P.A. (André) +6 more
core +1 more source
NKG2A and the functional competence of liver natural killer cells
The FASEB Journal, 2008 The liver is a unique environment that maintains tolerance to a heavy load of foreign antigens derived from the intestine. The liver is also the site of several chronic viral infections, including hepatitis B & C viruses.
Matthew G. Lassen, Young S. Hahn
openaire +1 more source
Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures [PDF]
, 2010 Background: Cytokine-induced killer (CIK) cells are typically differentiated in vitro with interferon (IFN)-gamma and alpha CD3 monoclonal antibodies (mAb), followed by the repeated provision of interleukin (IL)-2.
Alessandro Perillo +10 more
core +3 more sources